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学科主题: 药物依赖
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Protracted cocaine withdrawal produces circadian rhythmic alterations of phosphorylated GSK-3 beta in reward-related brain areas in rats
作者: Wei, Yi-ming2; Li, Su-xia1; Shi, Hai-shui1; Ding, Zeng-bo1; Luo, Yi-xiao1; Xue, Yan-xue1; Lu, Lin1; Yu, Chang-xi3
关键词: Circadian rhythm ; Protracted withdrawal ; Cocaine ; GSK-3 beta
刊名: BEHAVIOURAL BRAIN RESEARCH
发表日期: 2011-03-17
DOI: 10.1016/j.bbr.2010.11.054
卷: 218, 期:1, 页:228-233
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Behavioral Sciences ; Neurosciences
研究领域[WOS]: Behavioral Sciences ; Neurosciences & Neurology
关键词[WOS]: GLYCOGEN-SYNTHASE KINASE-3 ; LONG-TERM POTENTIATION ; PREFRONTAL CORTEX ; SYNAPTIC PLASTICITY ; SIGNALING PATHWAY ; DOPAMINE ; ABSTINENCE ; ADDICTION ; CLOCK ; SENSITIZATION
英文摘要:

Protracted cocaine withdrawal can extend for months and contribute to cocaine seeking and relapse. However, no previous studies have reported the manifestation of protracted withdrawal from chronic cocaine in rats. Glycogen synthase kinase 3 beta (GSK-3 beta) can phosphorylate PER2, CRY2, Rev-erb alpha, and BMAL1 in mammals. The circadian rhythmic expression of GSK-3 beta in reward-related brain areas is unclear. We examined rodent behaviors and circadian disturbances of GSK-3 beta expression during 30 days of protracted cocaine withdrawal. The behavioral tests included open field, elevated plus maze, weight gain, and sucrose preference tests performed 3, 10, and 30 days after stopping cocaine. At these three assessment points, we collected brain samples every 4 h for 24 h to examine the circadian rhythmic expression of GSK-3 beta. Decreased loco motor activity, weight loss, decreased sucrose consumption on day 3, and increased time spent in the open arms of the elevated plus maze on day 10 after cocaine administration were found. Blunted circadian rhythms of phosphorylated GFK-3 beta (pGSK-3 beta) persisted for at least 30 days in all examined brain areas, with the exception of 10 days in the suprachiasmatic nucleus (SCN) and nucleus accumbens (NAc). The expression of pGSK-3 beta decreased in the SCN and increased in the NAc and ventral tegmental area persisted for at least 30 days, whereas in the prefrontal cortex decreased during withdrawal for 10 days but then reversed to abnormally high levels with protracted withdrawal. These long-lasting changes disrupted circadian rhythms and produced abnormal levels of phosphorylated GSK-3 beta protein in reward-related brain circuits, which may play a role in protracted cocaine withdrawal and contribute to relapse. (C) 2010 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 20090001120132 ; 2010J01174 ; 09G0762
项目资助者: Department of Education of China ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Beijing Municipality
WOS记录号: WOS:000289137200030
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52817
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
2.Fujian Med Univ, Inst Basic Med, Fuzhou 350108, Peoples R China
3.Fujian Med Univ, Coll Pharm, Fuzhou 350108, Peoples R China

Recommended Citation:
Wei, Yi-ming,Li, Su-xia,Shi, Hai-shui,et al. Protracted cocaine withdrawal produces circadian rhythmic alterations of phosphorylated GSK-3 beta in reward-related brain areas in rats[J]. BEHAVIOURAL BRAIN RESEARCH,2011,218(1):228-233.
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