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Protracted cocaine withdrawal produces circadian rhythmic alterations of phosphorylated GSK-3 beta in reward-related brain areas in rats
Wei, Yi-ming2; Li, Su-xia1; Shi, Hai-shui1; Ding, Zeng-bo1; Luo, Yi-xiao1; Xue, Yan-xue1; Lu, Lin1; Yu, Chang-xi3
关键词Circadian Rhythm Protracted Withdrawal Cocaine Gsk-3 Beta
刊名BEHAVIOURAL BRAIN RESEARCH
2011-03-17
DOI10.1016/j.bbr.2010.11.054
218期:1页:228-233
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Behavioral Sciences ; Neurosciences
资助者Department of Education of China ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Beijing Municipality ; Department of Education of China ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Beijing Municipality
研究领域[WOS]Behavioral Sciences ; Neurosciences & Neurology
关键词[WOS]GLYCOGEN-SYNTHASE KINASE-3 ; LONG-TERM POTENTIATION ; PREFRONTAL CORTEX ; SYNAPTIC PLASTICITY ; SIGNALING PATHWAY ; DOPAMINE ; ABSTINENCE ; ADDICTION ; CLOCK ; SENSITIZATION
英文摘要

Protracted cocaine withdrawal can extend for months and contribute to cocaine seeking and relapse. However, no previous studies have reported the manifestation of protracted withdrawal from chronic cocaine in rats. Glycogen synthase kinase 3 beta (GSK-3 beta) can phosphorylate PER2, CRY2, Rev-erb alpha, and BMAL1 in mammals. The circadian rhythmic expression of GSK-3 beta in reward-related brain areas is unclear. We examined rodent behaviors and circadian disturbances of GSK-3 beta expression during 30 days of protracted cocaine withdrawal. The behavioral tests included open field, elevated plus maze, weight gain, and sucrose preference tests performed 3, 10, and 30 days after stopping cocaine. At these three assessment points, we collected brain samples every 4 h for 24 h to examine the circadian rhythmic expression of GSK-3 beta. Decreased loco motor activity, weight loss, decreased sucrose consumption on day 3, and increased time spent in the open arms of the elevated plus maze on day 10 after cocaine administration were found. Blunted circadian rhythms of phosphorylated GFK-3 beta (pGSK-3 beta) persisted for at least 30 days in all examined brain areas, with the exception of 10 days in the suprachiasmatic nucleus (SCN) and nucleus accumbens (NAc). The expression of pGSK-3 beta decreased in the SCN and increased in the NAc and ventral tegmental area persisted for at least 30 days, whereas in the prefrontal cortex decreased during withdrawal for 10 days but then reversed to abnormally high levels with protracted withdrawal. These long-lasting changes disrupted circadian rhythms and produced abnormal levels of phosphorylated GSK-3 beta protein in reward-related brain circuits, which may play a role in protracted cocaine withdrawal and contribute to relapse. (C) 2010 Elsevier B.V. All rights reserved.

语种英语
所属项目编号20090001120132 ; 2010J01174 ; 09G0762
资助者Department of Education of China ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Beijing Municipality ; Department of Education of China ; Natural Science Foundation of Fujian Province ; Natural Science Foundation of Beijing Municipality
WOS记录号WOS:000289137200030
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52817
专题中国药物依赖性研究所
作者单位1.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
2.Fujian Med Univ, Inst Basic Med, Fuzhou 350108, Peoples R China
3.Fujian Med Univ, Coll Pharm, Fuzhou 350108, Peoples R China
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Wei, Yi-ming,Li, Su-xia,Shi, Hai-shui,et al. Protracted cocaine withdrawal produces circadian rhythmic alterations of phosphorylated GSK-3 beta in reward-related brain areas in rats[J]. BEHAVIOURAL BRAIN RESEARCH,2011,218(1):228-233.
APA Wei, Yi-ming.,Li, Su-xia.,Shi, Hai-shui.,Ding, Zeng-bo.,Luo, Yi-xiao.,...&Yu, Chang-xi.(2011).Protracted cocaine withdrawal produces circadian rhythmic alterations of phosphorylated GSK-3 beta in reward-related brain areas in rats.BEHAVIOURAL BRAIN RESEARCH,218(1),228-233.
MLA Wei, Yi-ming,et al."Protracted cocaine withdrawal produces circadian rhythmic alterations of phosphorylated GSK-3 beta in reward-related brain areas in rats".BEHAVIOURAL BRAIN RESEARCH 218.1(2011):228-233.
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