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学科主题: 临床医学
题名:
VSTM-v1, a potential myeloid differentiation antigen that is downregulated in bone marrow cells from myeloid leukemia patients
作者: Xie, Min1,2; Li, Ting3; Li, Ning1,2; Li, Jinlan1,2; Yao, Qiumei1,2; Han, Wenling3; Ruan, Guorui1,2
关键词: Acute myeloid leukemia ; Leukocyte differentiation antigen ; VSTM1 ; Methylation ; Biomarker
刊名: JOURNAL OF HEMATOLOGY & ONCOLOGY
发表日期: 2015-03-15
DOI: 10.1186/s13045-015-0118-4
卷: 8
收录类别: SCI
文章类型: Letter
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Hematology
研究领域[WOS]: Oncology ; Hematology
关键词[WOS]: SIGNAL INHIBITORY RECEPTOR ; HUMAN PHAGOCYTES ; LEUKOCYTES-1
英文摘要:

Leukocyte differentiation antigens often represent important markers for the diagnosis, classification, prognosis, and therapeutic targeting of myeloid leukemia. Herein, we report a potential leukocyte differentiation antigen gene VSTM1 (V-set and transmembrane domain-containing 1) that was downregulated in bone marrow cells from leukemia patients and exhibited a higher degree of promoter methylation. The expression level of its predominant encoded product, VSTM1-v1, was positively correlated with myeloid cell maturation state. Restoration of VSTM1-v1 expression inhibited myeloid leukemia cells′ growth. Therefore, VSTM1-v1 might represent an important myeloid leukocyte differentiation antigen and provide a potential target for the diagnosis and treatment of leukemia.

语种: 英语
WOS记录号: WOS:000353271900001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52819
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Beijing 100044, Peoples R China
2.Inst Hematol, Beijing 100044, Peoples R China
3.Peking Univ, Ctr Human Dis Genom, Dept Immunol, Minist Hlth,Key Lab Med Immunol,Hlth Sci Ctr,Sch, Beijing 100191, Peoples R China

Recommended Citation:
Xie, Min,Li, Ting,Li, Ning,et al. VSTM-v1, a potential myeloid differentiation antigen that is downregulated in bone marrow cells from myeloid leukemia patients[J]. JOURNAL OF HEMATOLOGY & ONCOLOGY,2015,8.
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