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VSTM-v1, a potential myeloid differentiation antigen that is downregulated in bone marrow cells from myeloid leukemia patients
Xie, Min1,2; Li, Ting3; Li, Ning1,2; Li, Jinlan1,2; Yao, Qiumei1,2; Han, Wenling3; Ruan, Guorui1,2
关键词Acute Myeloid Leukemia Leukocyte Differentiation Antigen Vstm1 Methylation Biomarker
刊名JOURNAL OF HEMATOLOGY & ONCOLOGY
2015-03-15
DOI10.1186/s13045-015-0118-4
8
收录类别SCI
文章类型Letter
WOS标题词Science & Technology
类目[WOS]Oncology ; Hematology
研究领域[WOS]Oncology ; Hematology
关键词[WOS]SIGNAL INHIBITORY RECEPTOR ; HUMAN PHAGOCYTES ; LEUKOCYTES-1
英文摘要

Leukocyte differentiation antigens often represent important markers for the diagnosis, classification, prognosis, and therapeutic targeting of myeloid leukemia. Herein, we report a potential leukocyte differentiation antigen gene VSTM1 (V-set and transmembrane domain-containing 1) that was downregulated in bone marrow cells from leukemia patients and exhibited a higher degree of promoter methylation. The expression level of its predominant encoded product, VSTM1-v1, was positively correlated with myeloid cell maturation state. Restoration of VSTM1-v1 expression inhibited myeloid leukemia cells′ growth. Therefore, VSTM1-v1 might represent an important myeloid leukocyte differentiation antigen and provide a potential target for the diagnosis and treatment of leukemia.

语种英语
WOS记录号WOS:000353271900001
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52819
专题北京大学第二临床医学院
北京大学基础医学院
北京大学第二临床医学院_血液科
北京大学第三临床医学院_儿科
作者单位1.Peking Univ, Peoples Hosp, Beijing 100044, Peoples R China
2.Inst Hematol, Beijing 100044, Peoples R China
3.Peking Univ, Ctr Human Dis Genom, Dept Immunol, Minist Hlth,Key Lab Med Immunol,Hlth Sci Ctr,Sch, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Xie, Min,Li, Ting,Li, Ning,et al. VSTM-v1, a potential myeloid differentiation antigen that is downregulated in bone marrow cells from myeloid leukemia patients[J]. JOURNAL OF HEMATOLOGY & ONCOLOGY,2015,8.
APA Xie, Min.,Li, Ting.,Li, Ning.,Li, Jinlan.,Yao, Qiumei.,...&Ruan, Guorui.(2015).VSTM-v1, a potential myeloid differentiation antigen that is downregulated in bone marrow cells from myeloid leukemia patients.JOURNAL OF HEMATOLOGY & ONCOLOGY,8.
MLA Xie, Min,et al."VSTM-v1, a potential myeloid differentiation antigen that is downregulated in bone marrow cells from myeloid leukemia patients".JOURNAL OF HEMATOLOGY & ONCOLOGY 8(2015).
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