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Commercial soy milk enhances the development of 7,12-dimethylbenz(a)anthracene-induced mammary tumors in rats
Qin, Li-Qiang1; Xu, Jia-Ying1; Tezuka, Hideo1; Wang, Pei-Yu1; Hoshi, Kazuhiko1
关键词Soy Milk Isoflavone Estradiol Mammary Tumor
刊名IN VIVO
2007-07-01
21期:4页:667-671
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]SPRAGUE-DAWLEY RATS ; BREAST-CANCER ; ISOFLAVONES ; GENISTEIN ; GROWTH ; WOMEN ; CARCINOGENESIS ; INDUCTION ; PROMOTES ; PROTEIN
英文摘要

Background: Soy milk is a major soy food in China and Japan. Isoflavones in soy food are considered to protect women again breast cancer. Materials and Methods: The effects of soy milk consumption on 7,12-dimethylbenz(a) anthracene (DMBA)-induced mammary tumors in adult female rats was investigated. Sprague-Dawley rats were given 5 mg DMBA via intragastric intubation and then assigned to receive soy milk or water in addition to a normal rodent diet. Body weights, liquid and food intake, tumor number, location and development were recorded. After 20 weeks, liver, uterus and mammary tumors were removed from the sacrificed animals and examined. Plasma 17 beta-estradiol concentration was also determined. Results: After 20 weeks of DMBA administration, all of the rats that drank soy milk developed mammary tumors, while the incidence in the control group was 70% (p < 0.01). Tumor multiplicity increased in the soy milk group with borderline significance (p = 0. 06). Total tumor weight and size in the soy milk group were 1.5-fold greater than in the control group, without a significant difference (p > 0. 05). Uterine weight and plasma 17 beta-estradiol concentrations were similar in the two groups. Conclusion: Our results suggest that commercial soy milk enhanced the development of DMBA-induced mammary tumors in rats. Thus, careful consideration should be given when explaining the beneficial effects of soy food.

语种英语
WOS记录号WOS:000248568600019
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52820
专题北京大学公共卫生学院
作者单位1.Univ Yamanashi, Ctr Life Sci Res, Yamanashi 4093898, Japan
2.Univ Yamanashi, Dept Obstet & Gynecol, Sch Med, Yamanashi 4093898, Japan
3.Soochow Univ, Sch Radiat Med & Publ Hlth, Suzhou, Peoples R China
4.Peking Univ, Sch Publ Hlth, Dept Social Med & Hlth Educ, Beijing 100871, Peoples R China
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GB/T 7714
Qin, Li-Qiang,Xu, Jia-Ying,Tezuka, Hideo,et al. Commercial soy milk enhances the development of 7,12-dimethylbenz(a)anthracene-induced mammary tumors in rats[J]. IN VIVO,2007,21(4):667-671.
APA Qin, Li-Qiang,Xu, Jia-Ying,Tezuka, Hideo,Wang, Pei-Yu,&Hoshi, Kazuhiko.(2007).Commercial soy milk enhances the development of 7,12-dimethylbenz(a)anthracene-induced mammary tumors in rats.IN VIVO,21(4),667-671.
MLA Qin, Li-Qiang,et al."Commercial soy milk enhances the development of 7,12-dimethylbenz(a)anthracene-induced mammary tumors in rats".IN VIVO 21.4(2007):667-671.
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