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学科主题: 公共卫生
题名:
Commercial soy milk enhances the development of 7,12-dimethylbenz(a)anthracene-induced mammary tumors in rats
作者: Qin, Li-Qiang1; Xu, Jia-Ying1; Tezuka, Hideo1; Wang, Pei-Yu1; Hoshi, Kazuhiko1
关键词: soy milk ; isoflavone ; estradiol ; mammary tumor
刊名: IN VIVO
发表日期: 2007-07-01
卷: 21, 期:4, 页:667-671
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: SPRAGUE-DAWLEY RATS ; BREAST-CANCER ; ISOFLAVONES ; GENISTEIN ; GROWTH ; WOMEN ; CARCINOGENESIS ; INDUCTION ; PROMOTES ; PROTEIN
英文摘要:

Background: Soy milk is a major soy food in China and Japan. Isoflavones in soy food are considered to protect women again breast cancer. Materials and Methods: The effects of soy milk consumption on 7,12-dimethylbenz(a) anthracene (DMBA)-induced mammary tumors in adult female rats was investigated. Sprague-Dawley rats were given 5 mg DMBA via intragastric intubation and then assigned to receive soy milk or water in addition to a normal rodent diet. Body weights, liquid and food intake, tumor number, location and development were recorded. After 20 weeks, liver, uterus and mammary tumors were removed from the sacrificed animals and examined. Plasma 17 beta-estradiol concentration was also determined. Results: After 20 weeks of DMBA administration, all of the rats that drank soy milk developed mammary tumors, while the incidence in the control group was 70% (p < 0.01). Tumor multiplicity increased in the soy milk group with borderline significance (p = 0. 06). Total tumor weight and size in the soy milk group were 1.5-fold greater than in the control group, without a significant difference (p > 0. 05). Uterine weight and plasma 17 beta-estradiol concentrations were similar in the two groups. Conclusion: Our results suggest that commercial soy milk enhanced the development of DMBA-induced mammary tumors in rats. Thus, careful consideration should be given when explaining the beneficial effects of soy food.

语种: 英语
WOS记录号: WOS:000248568600019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52820
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Univ Yamanashi, Ctr Life Sci Res, Yamanashi 4093898, Japan
2.Univ Yamanashi, Dept Obstet & Gynecol, Sch Med, Yamanashi 4093898, Japan
3.Soochow Univ, Sch Radiat Med & Publ Hlth, Suzhou, Peoples R China
4.Peking Univ, Sch Publ Hlth, Dept Social Med & Hlth Educ, Beijing 100871, Peoples R China

Recommended Citation:
Qin, Li-Qiang,Xu, Jia-Ying,Tezuka, Hideo,et al. Commercial soy milk enhances the development of 7,12-dimethylbenz(a)anthracene-induced mammary tumors in rats[J]. IN VIVO,2007,21(4):667-671.
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