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Truncated Afyap1 Attenuates Antifungal Susceptibility of Aspergillus fumigatus to Voriconazole and Confers Adaptation of the Fungus to Oxidative Stress
Qiao, Jianjun1,2,3; Liu, Wei1,2; Li, Ruoyu1,2
关键词Aspergillus Fumigatus Afyap1 Truncated Voriconazole Resistance
刊名MYCOPATHOLOGIA
2010-09-01
DOI10.1007/s11046-010-9309-2
170期:3页:155-160
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Mycology
研究领域[WOS]Mycology
关键词[WOS]MULTIDRUG-RESISTANCE ; SACCHAROMYCES-CEREVISIAE ; INVASIVE ASPERGILLOSIS ; CANDIDA-ALBICANS ; DRUG-RESISTANCE ; UPDATE ; GENE ; TRANSPORTER ; MECHANISMS ; AGENTS
英文摘要

In yeasts truncated YAP1 homologues confer antifungal resistance. Our previous work has identified Afyap1, a YAP1 homologue, in Aspergillus fumigatus and found that it is responsible for oxidative stress in vitro. In order to decipher whether truncated Afyap1 involves in antifungal resistance mechanism and in oxidative stress adaptation in A. fumigatus, we introduce a putatively hyperactive truncated Afyap1 into wild-type A. fumigatus. We found that the resulted A. fumigatus containing truncated Afyap1 attenuated susceptibility to voriconazole and resistance to various oxidants. However, the Afyap1 deletion mutant and the strain harboring multiple copies of full-length Afyap1 had voriconazole susceptibility comparable with that of a wild-type A. fumigatus strain. Our study demonstrates that the truncated Afyap1 may involve in antifungal resistance to voriconazole in A. fumigatus and that the truncated Afyap1 sufficiently confers tolerance to oxidative stress in A. fumigatus.

语种英语
WOS记录号WOS:000279698800002
项目编号107002
资助机构Chinese Ministry of Education
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52825
专题北京大学第三临床医学院_药剂科
北京大学第一临床医学院_皮肤性病科
作者单位1.Peking Univ, Res Ctr Med Mycol, Beijing 100871, Peoples R China
2.Peking Univ, Dept Dermatol, Hosp 1, Beijing 100871, Peoples R China
3.Zhejiang Univ, Dept Dermatol, Affiliated Hosp 1, Coll Med, Hangzhou 310003, Zhejiang, Peoples R China
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Qiao, Jianjun,Liu, Wei,Li, Ruoyu. Truncated Afyap1 Attenuates Antifungal Susceptibility of Aspergillus fumigatus to Voriconazole and Confers Adaptation of the Fungus to Oxidative Stress[J]. MYCOPATHOLOGIA,2010,170(3):155-160.
APA Qiao, Jianjun,Liu, Wei,&Li, Ruoyu.(2010).Truncated Afyap1 Attenuates Antifungal Susceptibility of Aspergillus fumigatus to Voriconazole and Confers Adaptation of the Fungus to Oxidative Stress.MYCOPATHOLOGIA,170(3),155-160.
MLA Qiao, Jianjun,et al."Truncated Afyap1 Attenuates Antifungal Susceptibility of Aspergillus fumigatus to Voriconazole and Confers Adaptation of the Fungus to Oxidative Stress".MYCOPATHOLOGIA 170.3(2010):155-160.
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