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学科主题: 临床医学
题名:
Truncated Afyap1 Attenuates Antifungal Susceptibility of Aspergillus fumigatus to Voriconazole and Confers Adaptation of the Fungus to Oxidative Stress
作者: Qiao, Jianjun1,2,3; Liu, Wei1,2; Li, Ruoyu1,2
关键词: Aspergillus fumigatus ; Afyap1 ; Truncated ; Voriconazole ; Resistance
刊名: MYCOPATHOLOGIA
发表日期: 2010-09-01
DOI: 10.1007/s11046-010-9309-2
卷: 170, 期:3, 页:155-160
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Mycology
研究领域[WOS]: Mycology
关键词[WOS]: MULTIDRUG-RESISTANCE ; SACCHAROMYCES-CEREVISIAE ; INVASIVE ASPERGILLOSIS ; CANDIDA-ALBICANS ; DRUG-RESISTANCE ; UPDATE ; GENE ; TRANSPORTER ; MECHANISMS ; AGENTS
英文摘要:

In yeasts truncated YAP1 homologues confer antifungal resistance. Our previous work has identified Afyap1, a YAP1 homologue, in Aspergillus fumigatus and found that it is responsible for oxidative stress in vitro. In order to decipher whether truncated Afyap1 involves in antifungal resistance mechanism and in oxidative stress adaptation in A. fumigatus, we introduce a putatively hyperactive truncated Afyap1 into wild-type A. fumigatus. We found that the resulted A. fumigatus containing truncated Afyap1 attenuated susceptibility to voriconazole and resistance to various oxidants. However, the Afyap1 deletion mutant and the strain harboring multiple copies of full-length Afyap1 had voriconazole susceptibility comparable with that of a wild-type A. fumigatus strain. Our study demonstrates that the truncated Afyap1 may involve in antifungal resistance to voriconazole in A. fumigatus and that the truncated Afyap1 sufficiently confers tolerance to oxidative stress in A. fumigatus.

语种: 英语
所属项目编号: 107002
项目资助者: Chinese Ministry of Education
WOS记录号: WOS:000279698800002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52825
Appears in Collections:北京大学第一临床医学院_皮肤性病科_期刊论文

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作者单位: 1.Peking Univ, Res Ctr Med Mycol, Beijing 100871, Peoples R China
2.Peking Univ, Dept Dermatol, Hosp 1, Beijing 100871, Peoples R China
3.Zhejiang Univ, Dept Dermatol, Affiliated Hosp 1, Coll Med, Hangzhou 310003, Zhejiang, Peoples R China

Recommended Citation:
Qiao, Jianjun,Liu, Wei,Li, Ruoyu. Truncated Afyap1 Attenuates Antifungal Susceptibility of Aspergillus fumigatus to Voriconazole and Confers Adaptation of the Fungus to Oxidative Stress[J]. MYCOPATHOLOGIA,2010,170(3):155-160.
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