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学科主题: 临床医学
题名:
Identification of chimeric TSNAX-DISC1 resulting from intergenic splicing in endometrial carcinoma through high-throughput RNA sequencing
作者: Li, Na1; Zheng, Jian1; Li, Hua1,2; Deng, Jieqiong1; Hu, Min3; Wu, Hongchun1; Li, Wei1; Li, Fang1,3; Lan, Xun3,4; Lu, Jiachun5; Zhou, Yifeng1
刊名: CARCINOGENESIS
发表日期: 2014-12-01
DOI: 10.1093/carcin/bgu201
卷: 35, 期:12, 页:2687-2697
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: FACTOR-X ; CELL-PROLIFERATION ; FUNCTIONAL-CHARACTERIZATION ; MESSENGER-RNA ; PROTEIN CTCF ; GENE FUSIONS ; HUMAN GENOME ; TB-RBP ; CANCER ; TRANSLIN
英文摘要:

Gene fusion is among the primary processes that generate new genes and has been well characterized as potent pathway of oncogenesis. Here, by high-throughput RNA sequencing in nine paired human endometrial carcinoma (EC) and matched non-cancerous tissues, we obtained that chimeric translin-associated factor X-disrupted-in-schizophrenia 1 (TSNAX-DISC1) occurred significantly upregulated in multiple EC samples. Experimental investigation showed that TSNAX-DISC1 appears to be formed by splicing without chromosomal rearrangement. The chimera expression inversely correlated with the binding of CCCTC-binding factor (CTCF) to the insulators. Subsequent investigations indicate that long intergenic non-coding RNA lincRNA-NR_034037, separating TSNAX from DISC1, regulates TSNAX-DISC1 production and TSNAX/DISC1 expression levels by extricating CTCF from insulators. Dysregulation of TSNAX influences steroidogenic factor-1-stimulated transcription on the StAR promoter, altering progesterone actions, implying the association with cancer. Together, these results advance our understanding of the mechanism in which lincRNA-NR_034037 regulates TSNAX-DISC1 formation programs that tightly regulate EC development.

语种: 英语
所属项目编号: 81001278 ; 81171895 ; 81472630 ; 81072366 ; 81202040 ; BK2011297 ; BE2012648 ; 20101561 ; SYS201235 ; 7142167
项目资助者: National Scientific Foundation of China ; Priority Academic Program Development of Jiangsu Higher Education Institutions, Jiangsu Provincial Natural Science Foundation ; Jiangsu Province Science and Technology Support Program ; Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry ; Suzhou Science and Technology Development Plan ; Beijing Municipal Natural Science Foundation
WOS记录号: WOS:000345836200007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52827
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Stanford Univ, Dept Genet, Stanford, CA 94304 USA
2.Soochow Univ, Coll Med, Dept Genet, Suzhou 215123, Peoples R China
3.Peking Univ, Dept Obstet & Gynecol, Hosp 3, Beijing 100191, Peoples R China
4.Soochow Univ, Affiliated Hosp 2, Dept Obstet & Gynecol, Suzhou 215004, Peoples R China
5.Guangzhou Med Univ, Inst Chem Carcinogenesis, State Key Lab Resp Dis, Guangzhou 510182, Guangdong, Peoples R China

Recommended Citation:
Li, Na,Zheng, Jian,Li, Hua,et al. Identification of chimeric TSNAX-DISC1 resulting from intergenic splicing in endometrial carcinoma through high-throughput RNA sequencing[J]. CARCINOGENESIS,2014,35(12):2687-2697.
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