北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 期刊论文
学科主题: 临床医学
题名:
Identification of chimeric TSNAX-DISC1 resulting from intergenic splicing in endometrial carcinoma through high-throughput RNA sequencing
作者: Li, Na1; Zheng, Jian1; Li, Hua1,2; Deng, Jieqiong1; Hu, Min3; Wu, Hongchun1; Li, Wei1; Li, Fang1,3; Lan, Xun3,4; Lu, Jiachun5; Zhou, Yifeng1
刊名: CARCINOGENESIS
发表日期: 2014-12-01
DOI: 10.1093/carcin/bgu201
卷: 35, 期:12, 页:2687-2697
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: FACTOR-X ; CELL-PROLIFERATION ; FUNCTIONAL-CHARACTERIZATION ; MESSENGER-RNA ; PROTEIN CTCF ; GENE FUSIONS ; HUMAN GENOME ; TB-RBP ; CANCER ; TRANSLIN
英文摘要:

Gene fusion is among the primary processes that generate new genes and has been well characterized as potent pathway of oncogenesis. Here, by high-throughput RNA sequencing in nine paired human endometrial carcinoma (EC) and matched non-cancerous tissues, we obtained that chimeric translin-associated factor X-disrupted-in-schizophrenia 1 (TSNAX-DISC1) occurred significantly upregulated in multiple EC samples. Experimental investigation showed that TSNAX-DISC1 appears to be formed by splicing without chromosomal rearrangement. The chimera expression inversely correlated with the binding of CCCTC-binding factor (CTCF) to the insulators. Subsequent investigations indicate that long intergenic non-coding RNA lincRNA-NR_034037, separating TSNAX from DISC1, regulates TSNAX-DISC1 production and TSNAX/DISC1 expression levels by extricating CTCF from insulators. Dysregulation of TSNAX influences steroidogenic factor-1-stimulated transcription on the StAR promoter, altering progesterone actions, implying the association with cancer. Together, these results advance our understanding of the mechanism in which lincRNA-NR_034037 regulates TSNAX-DISC1 formation programs that tightly regulate EC development.

语种: 英语
所属项目编号: 81001278 ; 81171895 ; 81472630 ; 81072366 ; 81202040 ; BK2011297 ; BE2012648 ; 20101561 ; SYS201235 ; 7142167
项目资助者: National Scientific Foundation of China ; Priority Academic Program Development of Jiangsu Higher Education Institutions, Jiangsu Provincial Natural Science Foundation ; Jiangsu Province Science and Technology Support Program ; Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry ; Suzhou Science and Technology Development Plan ; Beijing Municipal Natural Science Foundation
WOS记录号: WOS:000345836200007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52827
Appears in Collections:北京大学第三临床医学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Stanford Univ, Dept Genet, Stanford, CA 94304 USA
2.Soochow Univ, Coll Med, Dept Genet, Suzhou 215123, Peoples R China
3.Peking Univ, Dept Obstet & Gynecol, Hosp 3, Beijing 100191, Peoples R China
4.Soochow Univ, Affiliated Hosp 2, Dept Obstet & Gynecol, Suzhou 215004, Peoples R China
5.Guangzhou Med Univ, Inst Chem Carcinogenesis, State Key Lab Resp Dis, Guangzhou 510182, Guangdong, Peoples R China

Recommended Citation:
Li, Na,Zheng, Jian,Li, Hua,et al. Identification of chimeric TSNAX-DISC1 resulting from intergenic splicing in endometrial carcinoma through high-throughput RNA sequencing[J]. CARCINOGENESIS,2014,35(12):2687-2697.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Li, Na]'s Articles
[Zheng, Jian]'s Articles
[Li, Hua]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Li, Na]‘s Articles
[Zheng, Jian]‘s Articles
[Li, Hua]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace