IR@PKUHSC  > 北京大学第三临床医学院
学科主题临床医学
Identification of chimeric TSNAX-DISC1 resulting from intergenic splicing in endometrial carcinoma through high-throughput RNA sequencing
Li, Na1; Zheng, Jian1; Li, Hua1,2; Deng, Jieqiong1; Hu, Min3; Wu, Hongchun1; Li, Wei1; Li, Fang1,3; Lan, Xun3,4; Lu, Jiachun5; Zhou, Yifeng1
刊名CARCINOGENESIS
2014-12-01
DOI10.1093/carcin/bgu201
35期:12页:2687-2697
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
资助者National Scientific Foundation of China ; Priority Academic Program Development of Jiangsu Higher Education Institutions, Jiangsu Provincial Natural Science Foundation ; Jiangsu Province Science and Technology Support Program ; Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry ; Suzhou Science and Technology Development Plan ; Beijing Municipal Natural Science Foundation ; National Scientific Foundation of China ; Priority Academic Program Development of Jiangsu Higher Education Institutions, Jiangsu Provincial Natural Science Foundation ; Jiangsu Province Science and Technology Support Program ; Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry ; Suzhou Science and Technology Development Plan ; Beijing Municipal Natural Science Foundation
研究领域[WOS]Oncology
关键词[WOS]FACTOR-X ; CELL-PROLIFERATION ; FUNCTIONAL-CHARACTERIZATION ; MESSENGER-RNA ; PROTEIN CTCF ; GENE FUSIONS ; HUMAN GENOME ; TB-RBP ; CANCER ; TRANSLIN
英文摘要

Gene fusion is among the primary processes that generate new genes and has been well characterized as potent pathway of oncogenesis. Here, by high-throughput RNA sequencing in nine paired human endometrial carcinoma (EC) and matched non-cancerous tissues, we obtained that chimeric translin-associated factor X-disrupted-in-schizophrenia 1 (TSNAX-DISC1) occurred significantly upregulated in multiple EC samples. Experimental investigation showed that TSNAX-DISC1 appears to be formed by splicing without chromosomal rearrangement. The chimera expression inversely correlated with the binding of CCCTC-binding factor (CTCF) to the insulators. Subsequent investigations indicate that long intergenic non-coding RNA lincRNA-NR_034037, separating TSNAX from DISC1, regulates TSNAX-DISC1 production and TSNAX/DISC1 expression levels by extricating CTCF from insulators. Dysregulation of TSNAX influences steroidogenic factor-1-stimulated transcription on the StAR promoter, altering progesterone actions, implying the association with cancer. Together, these results advance our understanding of the mechanism in which lincRNA-NR_034037 regulates TSNAX-DISC1 formation programs that tightly regulate EC development.

语种英语
所属项目编号81001278 ; 81171895 ; 81472630 ; 81072366 ; 81202040 ; BK2011297 ; BE2012648 ; 20101561 ; SYS201235 ; 7142167
资助者National Scientific Foundation of China ; Priority Academic Program Development of Jiangsu Higher Education Institutions, Jiangsu Provincial Natural Science Foundation ; Jiangsu Province Science and Technology Support Program ; Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry ; Suzhou Science and Technology Development Plan ; Beijing Municipal Natural Science Foundation ; National Scientific Foundation of China ; Priority Academic Program Development of Jiangsu Higher Education Institutions, Jiangsu Provincial Natural Science Foundation ; Jiangsu Province Science and Technology Support Program ; Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry ; Suzhou Science and Technology Development Plan ; Beijing Municipal Natural Science Foundation
WOS记录号WOS:000345836200007
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52827
专题北京大学第三临床医学院
作者单位1.Stanford Univ, Dept Genet, Stanford, CA 94304 USA
2.Soochow Univ, Coll Med, Dept Genet, Suzhou 215123, Peoples R China
3.Peking Univ, Dept Obstet & Gynecol, Hosp 3, Beijing 100191, Peoples R China
4.Soochow Univ, Affiliated Hosp 2, Dept Obstet & Gynecol, Suzhou 215004, Peoples R China
5.Guangzhou Med Univ, Inst Chem Carcinogenesis, State Key Lab Resp Dis, Guangzhou 510182, Guangdong, Peoples R China
推荐引用方式
GB/T 7714
Li, Na,Zheng, Jian,Li, Hua,et al. Identification of chimeric TSNAX-DISC1 resulting from intergenic splicing in endometrial carcinoma through high-throughput RNA sequencing[J]. CARCINOGENESIS,2014,35(12):2687-2697.
APA Li, Na.,Zheng, Jian.,Li, Hua.,Deng, Jieqiong.,Hu, Min.,...&Zhou, Yifeng.(2014).Identification of chimeric TSNAX-DISC1 resulting from intergenic splicing in endometrial carcinoma through high-throughput RNA sequencing.CARCINOGENESIS,35(12),2687-2697.
MLA Li, Na,et al."Identification of chimeric TSNAX-DISC1 resulting from intergenic splicing in endometrial carcinoma through high-throughput RNA sequencing".CARCINOGENESIS 35.12(2014):2687-2697.
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