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学科主题: 精神卫生
题名:
Association between variants of zinc finger genes and psychiatric disorders: Systematic review and meta-analysis
作者: Sun, Yan1,6; Hu, Die1,6; Liang, Jie1,6; Bao, Yan-Ping1,6; Meng, Shi-Qiu1,2,3,4,5,6; Lu, Lin1,2,3,4,5,6; Shi, Jie1,6,7,8,9
关键词: Psychiatric disorders ; ZNF804A ; Zinc finger genes ; Meta-analysis ; Genetic variants
刊名: SCHIZOPHRENIA RESEARCH
发表日期: 2015-03-01
DOI: 10.1016/j.schres.2015.01.036
卷: 162, 期:1-3, 页:124-137
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Psychiatry
研究领域[WOS]: Psychiatry
关键词[WOS]: SUPPORTED PSYCHOSIS VARIANT ; GENOME-WIDE ASSOCIATION ; DORSOLATERAL PREFRONTAL CORTEX ; AUTISM SPECTRUM DISORDER ; CARDIO-FACIAL SYNDROME ; DEFAULT-MODE NETWORK ; ZNF804A GENE ; BIPOLAR DISORDER ; SCHIZOPHRENIA SUSCEPTIBILITY ; POLYMORPHISM RS1344706
英文摘要:

Psychiatric disorders have a negative impact on society and human lives. Genetic factors are involved in the occurrence and development of psychiatric diseases. ZNF804A has been identified as one of the most compelling risk genes associated with broad phenotypes related to psychosis. We conducted a systematic meta-analysis and reviewed ZNF804A variants in psychosis-related disorders, including schizophrenia, bipolar disorder, and attention-deficit hyperactivity disorder. We also summarized the association between other zinc finger protein genes (ZNFs) and psychiatric diseases. The meta-analysis included a total of six variants of ZNF804A and three variants of other ZNFs (ZDHHC8 and ZKSCAN4), and the effects of ZNF variants on neurocognition and neuroimaging phenotypes were reviewed. The biological functions of these variants are also presented. We verified that ZNF804A was significantly related to psychiatric diseases, and the association between ZNF804A rs1344706 and psychosis (schizophrenia and bipolar disorder) did not vary with disease or ethnicity. The main brain area regulated by ZNF804A rs1344706 was the dorsolateral prefrontal cortex. The effect of ZNF804A variants on cognition did not display consistency with different diseases or methodologies. These findings suggest that ZNF804A might play an important role in common pathogenesis of psychiatric diseases, and its variants are likely involved in regulating the expression of psychosis-related genes, especially the dopamine pathway genes. Further research should focus on the molecular mechanisms by which ZNF804A variants act in psychiatric diseases and related phenotypes. (C) 2015 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 81225009 ; U1402226 ; 81221002 ; 91132719 ; 2015CB553503
项目资助者: National Science Fund for Distinguished Young Scholars ; National Natural Science Foundation of China ; National Basic Research Program of China
WOS记录号: WOS:000349966400023
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52834
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Minist Educ, Key Lab Neurosci, Beijing 100191, Peoples R China
2.Minist Publ Hlth, Beijing 100191, Peoples R China
3.Natl Inst Drug Dependence, Beijing 100191, Peoples R China
4.Beijing Key Lab Drug Dependence Res, Beijing 100191, Peoples R China
5.State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
6.Peking Univ Sixth Hosp, Inst Mental Health, Beijing 100191, Peoples R China
7.Peking Univ, Key Lab Mental Hlth, Beijing 100191, Peoples R China
8.Peking Univ, Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China
9.Peking Univ, PKU IDG, McGovern Inst Brain Res, Beijing 100871, Peoples R China

Recommended Citation:
Sun, Yan,Hu, Die,Liang, Jie,et al. Association between variants of zinc finger genes and psychiatric disorders: Systematic review and meta-analysis[J]. SCHIZOPHRENIA RESEARCH,2015,162(1-3):124-137.
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