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学科主题临床医学
TCR spectratyping revealed T lymphocytes associated with graft-versus-host disease after allogeneic hematopoietic stem cell transplantation
Du, Jin-Wei; Gu, Jiang-Ying; Liu, Jing; Cen, Xi-Nan; Zhang, Ying; Ou, Yuan; Chu, Bin; Zhu, Ping
关键词Hematopoietic Stem Cell Transplantation T-cell Receptor Graft-versus-host Disease Spectratyping
刊名LEUKEMIA & LYMPHOMA
2007
DOI10.1080/10428190701474357
48期:8页:1618-1627
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Hematology
研究领域[WOS]Oncology ; Hematology
关键词[WOS]BONE-MARROW TRANSPLANTATION ; V-BETA REPERTOIRE ; PERIPHERAL-BLOOD ; IMMUNE RECONSTITUTION ; LONGITUDINAL ANALYSIS ; IN-VIVO ; IDENTIFICATION ; EXPANSION ; CLONES ; CLONOTYPES
英文摘要

Clonal expansion of T cells after allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been observed, but their characteristics remain to be fully elucidated. We report here that CD8(+) T cells were the dominant T lymphocytes seen and T-cell repertoire diversity decreased dramatically during the first 3 months after allo-HSCT. Patients with GVHD grade II-IV had significantly lower T-cell repertoire diversity compared with non-GVHD patients. TCR beta variable gene (TCRBV) subfamily 8, 5.1, 5.2, 4, and 13 were the five most frequently expanded subfamilies among these patients. Among the 49 over-expanded clones identified, clonotype "TCR3-5′′ and "TCR18-5′′ were isolated from four patients with HLA-A2 allele and skin GVHD. Their frequencies correlated well with skin symptoms (i. e. rash). Moreover, they were detected in donors but not detected in recipients before transplantation. Lastly, three common TCRBV CDR3 motifs shared by T cells related with GVHD were discovered: TGDS, GLAG, and GGG. These findings suggest that TCR spectratyping is helpful for revealing GVHD-related T cells and may have utility in early diagnosis.

语种英语
WOS记录号WOS:000248720900023
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52836
专题北京大学第一临床医学院_血液内科
作者单位Peking Univ, Hosp 1, Dept Hematol, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Du, Jin-Wei,Gu, Jiang-Ying,Liu, Jing,et al. TCR spectratyping revealed T lymphocytes associated with graft-versus-host disease after allogeneic hematopoietic stem cell transplantation[J]. LEUKEMIA & LYMPHOMA,2007,48(8):1618-1627.
APA Du, Jin-Wei.,Gu, Jiang-Ying.,Liu, Jing.,Cen, Xi-Nan.,Zhang, Ying.,...&Zhu, Ping.(2007).TCR spectratyping revealed T lymphocytes associated with graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.LEUKEMIA & LYMPHOMA,48(8),1618-1627.
MLA Du, Jin-Wei,et al."TCR spectratyping revealed T lymphocytes associated with graft-versus-host disease after allogeneic hematopoietic stem cell transplantation".LEUKEMIA & LYMPHOMA 48.8(2007):1618-1627.
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