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学科主题: 临床医学
题名:
Palmitoleate Induces Hepatic Steatosis but Suppresses Liver Inflammatory Response in Mice
作者: Guo, Xin1; Li, Honggui1; Xu, Hang1; Halim, Vera1; Zhang, Weiyu2; Wang, Huan2; Ong, Kuok Teong3; Woo, Shih-Lung1; Walzem, Rosemary L.1; Mashek, Douglas G.3; Dong, Hui4; Lu, Fuer4; Wei, Lai5; Huo, Yuqing6; Wu, Chaodong1
刊名: PLOS ONE
发表日期: 2012-06-29
DOI: 10.1371/journal.pone.0039286
卷: 7, 期:6
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: SYSTEMIC INSULIN-RESISTANCE ; FATTY LIVER ; ADIPOSE-TISSUE ; INDUCIBLE 6-PHOSPHOFRUCTO-2-KINASE ; DIABETES-MELLITUS ; DISEASE ; ACID ; ACTIVATION ; OBESITY ; HEPATOCYTES
英文摘要:

The interaction between fat deposition and inflammation during obesity contributes to the development of non-alcoholic fatty liver disease (NAFLD). The present study examined the effects of palmitoleate, a monounsaturated fatty acid (16:1n7), on liver metabolic and inflammatory responses, and investigated the mechanisms by which palmitoleate increases hepatocyte fatty acid synthase (FAS) expression. Male wild-type C57BL/6J mice were supplemented with palmitoleate and subjected to the assays to analyze hepatic steatosis and liver inflammatory response. Additionally, mouse primary hepatocytes were treated with palmitoleate and used to analyze fat deposition, the inflammatory response, and sterol regulatory element-binding protein 1c (SREBP1c) activation. Compared with controls, palmitoleate supplementation increased the circulating levels of palmitoleate and improved systemic insulin sensitivity. Locally, hepatic fat deposition and SREBP1c and FAS expression were significantly increased in palmitoleate-supplemented mice. These pro-lipogenic events were accompanied by improvement of liver insulin signaling. In addition, palmitoleate supplementation reduced the numbers of macrophages/Kupffer cells in livers of the treated mice. Consistently, supplementation of palmitoleate decreased the phosphorylation of nuclear factor kappa B (NF-kappa B, p65) and the expression of proinflammatory cytokines. These results were recapitulated in primary mouse hepatocytes. In terms of regulating FAS expression, treatment of palmitoleate increased the transcription activity of SREBP1c and enhanced the binding of SREBP1c to FAS promoter. Palmitoleate also decreased the phosphorylation of NF-kappa B p65 and the expression of proinflammatory cytokines in cultured macrophages. Together, these results suggest that palmitoleate acts through dissociating liver inflammatory response from hepatic steatosis to play a unique role in NAFLD.

语种: 英语
所属项目编号: 1-10-BS-76 ; 1-10-JF-54 ; HL78679 ; HL080569 ; 12BGIA9050003
项目资助者: American Diabetes Association (ADA) ; National Institutes of Health (NIH) ; American Heart Association (AHA)
WOS记录号: WOS:000305892100041
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52848
Appears in Collections:北京大学第二临床医学院_北京大学肝病研究所_期刊论文

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作者单位: 1.Texas A&M Univ, Dept Nutr & Food Sci, Intercollegiate Fac Nutr, College Stn, TX 77843 USA
2.Univ Minnesota, Dept Med, Minneapolis, MN 55455 USA
3.Univ Minnesota, Dept Food Sci & Nutr, St Paul, MN USA
4.Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Inst Integrated Chinese & Western Med, Wuhan 430074, Peoples R China
5.Peking Univ, Hlth Sci Ctr, Inst Hepatol, Beijing 100871, Peoples R China
6.Georgia Hlth Sci Univ, Dept Cellular Biol & Anat, Augusta, GA USA

Recommended Citation:
Guo, Xin,Li, Honggui,Xu, Hang,et al. Palmitoleate Induces Hepatic Steatosis but Suppresses Liver Inflammatory Response in Mice[J]. PLOS ONE,2012,7(6).
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