学科主题临床医学
Palmitoleate Induces Hepatic Steatosis but Suppresses Liver Inflammatory Response in Mice
Guo, Xin1; Li, Honggui1; Xu, Hang1; Halim, Vera1; Zhang, Weiyu2; Wang, Huan2; Ong, Kuok Teong3; Woo, Shih-Lung1; Walzem, Rosemary L.1; Mashek, Douglas G.3; Dong, Hui4; Lu, Fuer4; Wei, Lai5; Huo, Yuqing6; Wu, Chaodong1
刊名PLOS ONE
2012-06-29
DOI10.1371/journal.pone.0039286
7期:6
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]SYSTEMIC INSULIN-RESISTANCE ; FATTY LIVER ; ADIPOSE-TISSUE ; INDUCIBLE 6-PHOSPHOFRUCTO-2-KINASE ; DIABETES-MELLITUS ; DISEASE ; ACID ; ACTIVATION ; OBESITY ; HEPATOCYTES
英文摘要

The interaction between fat deposition and inflammation during obesity contributes to the development of non-alcoholic fatty liver disease (NAFLD). The present study examined the effects of palmitoleate, a monounsaturated fatty acid (16:1n7), on liver metabolic and inflammatory responses, and investigated the mechanisms by which palmitoleate increases hepatocyte fatty acid synthase (FAS) expression. Male wild-type C57BL/6J mice were supplemented with palmitoleate and subjected to the assays to analyze hepatic steatosis and liver inflammatory response. Additionally, mouse primary hepatocytes were treated with palmitoleate and used to analyze fat deposition, the inflammatory response, and sterol regulatory element-binding protein 1c (SREBP1c) activation. Compared with controls, palmitoleate supplementation increased the circulating levels of palmitoleate and improved systemic insulin sensitivity. Locally, hepatic fat deposition and SREBP1c and FAS expression were significantly increased in palmitoleate-supplemented mice. These pro-lipogenic events were accompanied by improvement of liver insulin signaling. In addition, palmitoleate supplementation reduced the numbers of macrophages/Kupffer cells in livers of the treated mice. Consistently, supplementation of palmitoleate decreased the phosphorylation of nuclear factor kappa B (NF-kappa B, p65) and the expression of proinflammatory cytokines. These results were recapitulated in primary mouse hepatocytes. In terms of regulating FAS expression, treatment of palmitoleate increased the transcription activity of SREBP1c and enhanced the binding of SREBP1c to FAS promoter. Palmitoleate also decreased the phosphorylation of NF-kappa B p65 and the expression of proinflammatory cytokines in cultured macrophages. Together, these results suggest that palmitoleate acts through dissociating liver inflammatory response from hepatic steatosis to play a unique role in NAFLD.

语种英语
WOS记录号WOS:000305892100041
引用统计
被引频次:54[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52848
专题北京大学第二临床医学院_北京大学肝病研究所
作者单位1.Texas A&M Univ, Dept Nutr & Food Sci, Intercollegiate Fac Nutr, College Stn, TX 77843 USA
2.Univ Minnesota, Dept Med, Minneapolis, MN 55455 USA
3.Univ Minnesota, Dept Food Sci & Nutr, St Paul, MN USA
4.Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Inst Integrated Chinese & Western Med, Wuhan 430074, Peoples R China
5.Peking Univ, Hlth Sci Ctr, Inst Hepatol, Beijing 100871, Peoples R China
6.Georgia Hlth Sci Univ, Dept Cellular Biol & Anat, Augusta, GA USA
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GB/T 7714
Guo, Xin,Li, Honggui,Xu, Hang,et al. Palmitoleate Induces Hepatic Steatosis but Suppresses Liver Inflammatory Response in Mice[J]. PLOS ONE,2012,7(6).
APA Guo, Xin.,Li, Honggui.,Xu, Hang.,Halim, Vera.,Zhang, Weiyu.,...&Wu, Chaodong.(2012).Palmitoleate Induces Hepatic Steatosis but Suppresses Liver Inflammatory Response in Mice.PLOS ONE,7(6).
MLA Guo, Xin,et al."Palmitoleate Induces Hepatic Steatosis but Suppresses Liver Inflammatory Response in Mice".PLOS ONE 7.6(2012).
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