IR@PKUHSC  > 北京大学基础医学院  > 免疫学系
学科主题基础医学
A novel ER-localized transmembrane protein, EMC6, interacts with RAB5A and regulates cell autophagy
Li, Yanjun1,2; Zhao, Yuanbo1,2; Hu, Jia1; Xiao, Juan1,2; Qu, Liujing1,2; Wang, Zhenda1,2; Ma, Dalong1,2; Chen, Yingyu1,2
关键词EMC6 autophagy RAB5A BECN1 endoplasmic reticulum
刊名AUTOPHAGY
2013-02-01
DOI10.4161/auto.22742
9期:2页:150-163
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology
研究领域[WOS]Cell Biology
关键词[WOS]PHOSPHATIDYLINOSITOL 3-PHOSPHATE ; ENDOPLASMIC-RETICULUM ; HUNTINGTON-DISEASE ; FREEZE-FRACTURE ; MEMBRANES ; ATG14L ; MACROAUTOPHAGY ; POLYGLUTAMINE ; EXPANSIONS ; BIOGENESIS
英文摘要

Autophagy is mediated by a unique organelle, the autophagosome, which encloses a portion of the cytoplasm for delivery to the lysosome. Phosphatidylinositol 3-phosphate (PtdIns3P) produced by the class III phosphatidylinositol 3-kinase (PtdIns3K) complex is essential for canonical autophagosome formation. RAB5A, a small GTPase localized to early endosomes, has been shown to associate with the class III PtdIns3K complex, regulate its activity and promote autophagosome formation. However, little is known about how endosome-localized RAB5A functions with the class III PtdIns3K complex. Here we identified a novel endoplasmic reticulum (ER)-localized transmembrane protein, ER membrane protein complex subunit 6 (EMC6), which interacted with both RAB5A and BECN1/Beclin 1 and colocalized with the omegasome marker ZFYVE1/DFCP1. It was shown to regulate autophagosome formation, and its deficiency caused the accumulation of autophagosomal precursor structures and impaired autophagy. Our study showed for the first time that EMC6 is a novel regulator involved in autophagy.

语种英语
WOS记录号WOS:000314218700004
引用统计
被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52849
专题北京大学基础医学院_免疫学系
北京大学基础医学院
北京大学口腔医学院_儿童口腔科
作者单位1.Peking Univ, Hlth Sci Ctr, Minist Hlth, Key Lab Med Immunol, Beijing 100871, Peoples R China
2.Peking Univ, Peking Univ Ctr Human Dis Genom, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Li, Yanjun,Zhao, Yuanbo,Hu, Jia,et al. A novel ER-localized transmembrane protein, EMC6, interacts with RAB5A and regulates cell autophagy[J]. AUTOPHAGY,2013,9(2):150-163.
APA Li, Yanjun.,Zhao, Yuanbo.,Hu, Jia.,Xiao, Juan.,Qu, Liujing.,...&Chen, Yingyu.(2013).A novel ER-localized transmembrane protein, EMC6, interacts with RAB5A and regulates cell autophagy.AUTOPHAGY,9(2),150-163.
MLA Li, Yanjun,et al."A novel ER-localized transmembrane protein, EMC6, interacts with RAB5A and regulates cell autophagy".AUTOPHAGY 9.2(2013):150-163.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
A novel ER localized(8939KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Li, Yanjun]的文章
[Zhao, Yuanbo]的文章
[Hu, Jia]的文章
百度学术
百度学术中相似的文章
[Li, Yanjun]的文章
[Zhao, Yuanbo]的文章
[Hu, Jia]的文章
必应学术
必应学术中相似的文章
[Li, Yanjun]的文章
[Zhao, Yuanbo]的文章
[Hu, Jia]的文章
相关权益政策
暂无数据
收藏/分享
文件名: A novel ER localized transmembrane protein EMC6 interacts with RAB5A and regulates cell autophagy.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。