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学科主题: 基础医学
题名:
A novel ER-localized transmembrane protein, EMC6, interacts with RAB5A and regulates cell autophagy
作者: Li, Yanjun1,2; Zhao, Yuanbo1,2; Hu, Jia1; Xiao, Juan1,2; Qu, Liujing1,2; Wang, Zhenda1,2; Ma, Dalong1,2; Chen, Yingyu1,2
关键词: EMC6 ; autophagy ; RAB5A ; BECN1 ; endoplasmic reticulum
刊名: AUTOPHAGY
发表日期: 2013-02-01
DOI: 10.4161/auto.22742
卷: 9, 期:2, 页:150-163
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology
研究领域[WOS]: Cell Biology
关键词[WOS]: PHOSPHATIDYLINOSITOL 3-PHOSPHATE ; ENDOPLASMIC-RETICULUM ; HUNTINGTON-DISEASE ; FREEZE-FRACTURE ; MEMBRANES ; ATG14L ; MACROAUTOPHAGY ; POLYGLUTAMINE ; EXPANSIONS ; BIOGENESIS
英文摘要:

Autophagy is mediated by a unique organelle, the autophagosome, which encloses a portion of the cytoplasm for delivery to the lysosome. Phosphatidylinositol 3-phosphate (PtdIns3P) produced by the class III phosphatidylinositol 3-kinase (PtdIns3K) complex is essential for canonical autophagosome formation. RAB5A, a small GTPase localized to early endosomes, has been shown to associate with the class III PtdIns3K complex, regulate its activity and promote autophagosome formation. However, little is known about how endosome-localized RAB5A functions with the class III PtdIns3K complex. Here we identified a novel endoplasmic reticulum (ER)-localized transmembrane protein, ER membrane protein complex subunit 6 (EMC6), which interacted with both RAB5A and BECN1/Beclin 1 and colocalized with the omegasome marker ZFYVE1/DFCP1. It was shown to regulate autophagosome formation, and its deficiency caused the accumulation of autophagosomal precursor structures and impaired autophagy. Our study showed for the first time that EMC6 is a novel regulator involved in autophagy.

语种: 英语
所属项目编号: 2011CB910103
项目资助者: National Key Basic Research Program of China (973)
WOS记录号: WOS:000314218700004
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52849
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Minist Hlth, Key Lab Med Immunol, Beijing 100871, Peoples R China
2.Peking Univ, Peking Univ Ctr Human Dis Genom, Beijing 100871, Peoples R China

Recommended Citation:
Li, Yanjun,Zhao, Yuanbo,Hu, Jia,et al. A novel ER-localized transmembrane protein, EMC6, interacts with RAB5A and regulates cell autophagy[J]. AUTOPHAGY,2013,9(2):150-163.
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