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学科主题基础医学
Mesenchymal stem cells modified with angiopoietin-1 improve remodeling in a rat model of acute myocardial infarction
Sun Lijie1; Cui Ming1; Wang Zuoyan1; Feng Xinheng1; Mao Jieming1; Chen Ping1; Ma Kangtao1; Chen Fengrong1; Zhou Chunyan1
关键词Bone Marrow Mesenchymal Stem Cell Cell Transplantation Gene Therapy Angiopoietin-1 Acute Myocardial Infarction
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2007-06-08
DOI10.1016/j.bbrc.2007.04.010
357期:3页:779-784
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]STROMAL CELLS ; TRANSPLANTATION ; ANGIOGENESIS ; THERAPY
英文摘要

We used human angiopoietin-1 (hAng1)-modified mesenchymal stem cells (MSCs) to treat acute myocardial infarction (AMI) in rats. The hAng1 gene was transfected into cultured rat MSCs using an adenoviral vector. Five million hAng-transfected MSCS (MSCAng1) or green fluorescent protein transfected MSCs (MSCGFP) or PBS only (PBS group) were injected intramyocardially into the inbred Lewis rat hearts immediately after myocardial infarction. MSCAng1 survived in the infarcted myocardium, and expressed hAng1 at both mRNA and protein levels. The vascular density was higher in the MSCAng1 and MSCGFP groups than in the PBS group. The measurements of infarcted ventricular wall thickness, infarction area, and left ventricular diameter indicated that heart remodeling was inhibited and heart function was improved in both the MSCAng1 and MSCGFP groups. However, in contrast to the MSCGFP group, the MSCAng1 group showed enhanced angiogenesis and arteriogenesis (by 11-35%), infarction area was reduced by 30% and the left ventricular wall was 46% thicker (P < 0.05).

The results indicated that hAngl-modified MSCs improved heart function, followed by angiogenic effects in salvaging ischernic myocardium and reduced cardiac remodeling. (c) 2007 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000246382700035
引用统计
被引频次:52[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52851
专题北京大学基础医学院
北京大学药学院_药学院
北京大学第三临床医学院_心血管内科
作者单位1.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Biochem & Mol Biol, Beijing 100083, Peoples R China
2.Peking Univ, Hosp 3, Dept Biochem & Mol Biol, Beijing 100083, Peoples R China
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Sun Lijie,Cui Ming,Wang Zuoyan,et al. Mesenchymal stem cells modified with angiopoietin-1 improve remodeling in a rat model of acute myocardial infarction[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2007,357(3):779-784.
APA Sun Lijie.,Cui Ming.,Wang Zuoyan.,Feng Xinheng.,Mao Jieming.,...&Zhou Chunyan.(2007).Mesenchymal stem cells modified with angiopoietin-1 improve remodeling in a rat model of acute myocardial infarction.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,357(3),779-784.
MLA Sun Lijie,et al."Mesenchymal stem cells modified with angiopoietin-1 improve remodeling in a rat model of acute myocardial infarction".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 357.3(2007):779-784.
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