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学科主题: 基础医学
题名:
Mesenchymal stem cells modified with angiopoietin-1 improve remodeling in a rat model of acute myocardial infarction
作者: Sun Lijie1; Cui Ming1; Wang Zuoyan1; Feng Xinheng1; Mao Jieming1; Chen Ping1; Ma Kangtao1; Chen Fengrong1; Zhou Chunyan1
关键词: bone marrow mesenchymal stem cell ; cell transplantation ; gene therapy ; angiopoietin-1 ; acute myocardial infarction
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2007-06-08
DOI: 10.1016/j.bbrc.2007.04.010
卷: 357, 期:3, 页:779-784
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: STROMAL CELLS ; TRANSPLANTATION ; ANGIOGENESIS ; THERAPY
英文摘要:

We used human angiopoietin-1 (hAng1)-modified mesenchymal stem cells (MSCs) to treat acute myocardial infarction (AMI) in rats. The hAng1 gene was transfected into cultured rat MSCs using an adenoviral vector. Five million hAng-transfected MSCS (MSCAng1) or green fluorescent protein transfected MSCs (MSCGFP) or PBS only (PBS group) were injected intramyocardially into the inbred Lewis rat hearts immediately after myocardial infarction. MSCAng1 survived in the infarcted myocardium, and expressed hAng1 at both mRNA and protein levels. The vascular density was higher in the MSCAng1 and MSCGFP groups than in the PBS group. The measurements of infarcted ventricular wall thickness, infarction area, and left ventricular diameter indicated that heart remodeling was inhibited and heart function was improved in both the MSCAng1 and MSCGFP groups. However, in contrast to the MSCGFP group, the MSCAng1 group showed enhanced angiogenesis and arteriogenesis (by 11-35%), infarction area was reduced by 30% and the left ventricular wall was 46% thicker (P < 0.05).

The results indicated that hAngl-modified MSCs improved heart function, followed by angiogenic effects in salvaging ischernic myocardium and reduced cardiac remodeling. (c) 2007 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000246382700035
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52851
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Biochem & Mol Biol, Beijing 100083, Peoples R China
2.Peking Univ, Hosp 3, Dept Biochem & Mol Biol, Beijing 100083, Peoples R China

Recommended Citation:
Sun Lijie,Cui Ming,Wang Zuoyan,et al. Mesenchymal stem cells modified with angiopoietin-1 improve remodeling in a rat model of acute myocardial infarction[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2007,357(3):779-784.
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