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Polymorphisms of Transferrin gene are associated with schizophrenia in Chinese Han population
Qu, Mei; Yue, Weihua; Tang, Fulei; Wang, Lifang; Han, Yonghua; Zhang, Dai
关键词Schizophrenia Transferrin Myelination Haplotype Linkage Disequilibrium
刊名JOURNAL OF PSYCHIATRIC RESEARCH
2008-09-01
DOI10.1016/j.jpsychires.2007.10.005
42期:11页:877-883
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Psychiatry
研究领域[WOS]Psychiatry
关键词[WOS]MULTIPLE BRAIN-REGIONS ; MOG GENE ; MYELINATION ; EXPRESSION ; POSTMORTEM ; DIFFERENTIATION ; ABNORMALITIES ; DYSFUNCTION ; PROTEINS ; CORTEX
英文摘要

Several recent studies have provided evidence that abnormalities ill oligodeildrocyte and myelin function may contribute to the etiopathology of schizophrenia. Transferrin (TF), all iron transport glycoprotein playing all important role in synthesis of myclin and the development of oligodendrocytes, has been identified its down-regulated expression ill schizophrenia brain by microarray, quantitative PCR and ill situ hybridization method. Ill order to further assess the role of TF in schizophrenia, we examined seven polymorphisms in TF region using a set sample of Chinese Hart subjects consisting of 326 schizophrenia patients and 344 healthy controls. Four single nucleotide polymorphisms (SNPs) namely, rs4481157, rs3811655, rs6762415 and rsl405022 were analyzed ill this Study. Our results showed that one intronic SNP had strong association with schizophrenia (rs3811655: allele C > G P = 1.34E-6, OR = 1.89, 95%, Cl = 1.46-2.46; genotype P = 3.72E-6). Two haplotypes A-C and G-G constructed of rs4481157-rs3811655 also revealed significant associations with schizophrenia (global P = 0.0001). Our findings support that TF gene may be involved ill susceptibility to schizophrenia in the Chinese Hall population. However, further studies are needed to confirm these findings ill other populations and to identify functional variants ill TF that may be implicated ill pathogenesis. (C) 2007 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000258798300001
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被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52856
专题北京大学精神卫生研究所
北京大学公共卫生学院_公共卫生学院
北京大学第一临床医学院_妇产科
北京大学精神卫生研究所_精神科
作者单位Peking Univ, Minist Hlth, Inst Mental Hlth, Key Lab Mental Hlth, Beijing 100083, Peoples R China
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GB/T 7714
Qu, Mei,Yue, Weihua,Tang, Fulei,et al. Polymorphisms of Transferrin gene are associated with schizophrenia in Chinese Han population[J]. JOURNAL OF PSYCHIATRIC RESEARCH,2008,42(11):877-883.
APA Qu, Mei,Yue, Weihua,Tang, Fulei,Wang, Lifang,Han, Yonghua,&Zhang, Dai.(2008).Polymorphisms of Transferrin gene are associated with schizophrenia in Chinese Han population.JOURNAL OF PSYCHIATRIC RESEARCH,42(11),877-883.
MLA Qu, Mei,et al."Polymorphisms of Transferrin gene are associated with schizophrenia in Chinese Han population".JOURNAL OF PSYCHIATRIC RESEARCH 42.11(2008):877-883.
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