|An Outbreak of Type Pi Vaccine- Derived Poliovirus in Sichuan Province, China: Emergence and Circulation in an Under-Immunized Population|
|Wang, Hai-Bo1,2; Fang, Gang3; Yu, Wen-Zhou1; Du, Fei3; Fan, Chun-Xiang1; Liu, Qing-Lian3; Hao, Li-Xin1; Liu, Yu3; Zheng, Jing-Shan1; Qin, Zhi-Ying3; Xia, Wei1; Zhang, Shi-Yue4; Yin, Zun-Dong1; Jing, Qiong4; Zhang, Yan-Xia1; Huang, Rong-Na5; Yang, Ru-Pei5; Tong, Wen-Bin3; Qi, Qi3; Guan, Xu-Jing3; Jing, Yu-Lin3; Ma, Qian-Li3; Wang, Jin3; Ma, Xiao-Zhen3; Chen, Na3; Zheng, Hong-Ru3; Li, Yin-Qiao3; Ma, Chao1; Su, Qi-Ru1; Reilly, Kathleen H.6; Luo, Hui-Ming1; Wu, Xian-Ping3; Wen, Ning1; Yang, Wei-Zhong1|
|WOS标题词||Science & Technology|
|研究领域[WOS]||Science & Technology - Other Topics|
|关键词[WOS]||POLIOMYELITIS ; ERADICATION ; WORLDWIDE ; PROGRESS|
Background: During August 2011-February 2012, an outbreak of type P circulating vaccine-derived poliovirus (cVDPVs) occurred in Sichuan Province, China.
Methods: A field investigation of the outbreak was conducted to characterize outbreak isolates and to guide emergency response. Sequence analysis of poliovirus capsid protein VP1 was performed to determine the viral propagation, and a coverage survey was carried out for risk assessment.
Results: One clinical compatible polio case and three VDPV cases were determined in Ngawa County, Ngawa Tibetan and Qiang Autonomous Prefecture, Sichuan Province. Case patients were unimmunized children, 0.8-1 years old. Genetic sequencing showed that the isolates diverged from the VP1 region of the type P Sabin strain by 5-12 nucleotides (nt) and shared the same 5 nt VP1 substitutions, which indicate single lineage of cVDPVs. Of the 7 acute flaccid paralysis cases (all. 6 months) reported in Ngawa Prefecture in 2011, 4 (57.1%) cases (including 2 polio cases) did not receive oral attenuated poliovirus vaccine. Supplementary immunization activities (SIAs) were conducted in February-May, 2012, and the strain has not been isolated since.
Conclusion: High coverage of routine immunization should be maintained among children until WPV transmission is globally eradicated. Risk assessments should be conducted regularly to pinpoint high risk areas or subpopulations, with SIAs developed if necessary.
|作者单位||1.Peking Univ, Clin Res Inst, Beijing 100191, Peoples R China|
2.Chinese Ctr Dis Control & Prevent, Beijing 100050, Peoples R China
3.Sichuan Prov Ctr Dis Control & Prevent, Chengdu 610041, Sichuan Provinc, Peoples R China
4.Ngawa Tibetan & Qiang Autonomous Prefectural Ctr, Chengdu 624000, Sichuan Provinc, Peoples R China
5.Chengdu City Ctr Dis Control & Prevent, Chengdu 610041, Sichuan Provinc, Peoples R China
6.Chinese Ctr Dis Control & Prevent, Natl Ctr AIDS STD Control & Prevent, Beijing 100050, Peoples R China
|Wang, Hai-Bo,Fang, Gang,Yu, Wen-Zhou,et al. An Outbreak of Type Pi Vaccine- Derived Poliovirus in Sichuan Province, China: Emergence and Circulation in an Under-Immunized Population[J]. PLOS ONE,2014,9(12).|
|APA||Wang, Hai-Bo.,Fang, Gang.,Yu, Wen-Zhou.,Du, Fei.,Fan, Chun-Xiang.,...&Yang, Wei-Zhong.(2014).An Outbreak of Type Pi Vaccine- Derived Poliovirus in Sichuan Province, China: Emergence and Circulation in an Under-Immunized Population.PLOS ONE,9(12).|
|MLA||Wang, Hai-Bo,et al."An Outbreak of Type Pi Vaccine- Derived Poliovirus in Sichuan Province, China: Emergence and Circulation in an Under-Immunized Population".PLOS ONE 9.12(2014).|