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Inhibition of hyperpolarization-activated current by ZD7288 suppresses ectopic discharges of injured dorsal root ganglion neurons in a rat model of neuropathic pain
Sun, Q; Xing, GG; Tu, HY; Han, JS; Wan, Y
关键词neuropathic pain ectopic discharge I-h HCN channel ZD7288 teased fiber recording
刊名BRAIN RESEARCH
2005-01-25
DOI10.1016/j.brainres.2004.10.033
1032期:1-2页:63-69
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]SPINAL NERVE INJURY ; MEMBRANE-POTENTIAL OSCILLATIONS ; PRIMARY AFFERENT NEURONS ; THALAMIC RELAY NEURONS ; CURRENT I-H ; SENSORY NEURONS ; CATION CURRENT ; SODIUM-CHANNELS ; PACEMAKER CHANNELS ; CALCIUM CURRENT
英文摘要

Peripheral nerve injury causes ectopic discharges of different firing patterns, which may play an important role in the development of neuropathic pain. The molecular mechanisms underlying the generation of ectopic discharges are still unclear. In the present study, by using in vivo teased fiber recording technique we examined the effect of ZD7288, a specific blocker of hyperpolarization-activated current (I-h), on the ectopic discharges in the dorsal root ganglion (DRG) neurons injured by spinal nerve ligation. We found that ectopic discharges of all three firing patterns (tonic, bursting and irregular) were dose- and time-dependently inhibited by local application of ZD7288. Interestingly, the extent of suppression was negatively related to frequency of firing prior to application of ZD7288. We also observed that ZD7288 could alter the firing patterns of the ectopic discharges. At 100 muM, tonic firing pattern was gradually transformed into bursting type whereas at 1 mM, it could be transformed to integer multiples firing. These results indicate that I-h might play a role in the generation of various forms of ectopic discharges in the injured DRG neurons and may thus be a possible target for neuropathic pain treatment. (C) 2004 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000226935500008
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被引频次:41[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52874
专题北京大学基础医学院_神经生物学系
北京大学基础医学院
作者单位Peking Univ, Minist Educ, Neurosci Res Inst, Key Lab Neurosci, Beijing 100083, Peoples R China
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Sun, Q,Xing, GG,Tu, HY,et al. Inhibition of hyperpolarization-activated current by ZD7288 suppresses ectopic discharges of injured dorsal root ganglion neurons in a rat model of neuropathic pain[J]. BRAIN RESEARCH,2005,1032(1-2):63-69.
APA Sun, Q,Xing, GG,Tu, HY,Han, JS,&Wan, Y.(2005).Inhibition of hyperpolarization-activated current by ZD7288 suppresses ectopic discharges of injured dorsal root ganglion neurons in a rat model of neuropathic pain.BRAIN RESEARCH,1032(1-2),63-69.
MLA Sun, Q,et al."Inhibition of hyperpolarization-activated current by ZD7288 suppresses ectopic discharges of injured dorsal root ganglion neurons in a rat model of neuropathic pain".BRAIN RESEARCH 1032.1-2(2005):63-69.
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