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The effects of verapamil SR and bisoprolol on reducing the sympathetic nervous system′s activity
Sun, NL1; Hong, TT1; Zhang, RJ1; Yang, X1
关键词Hypertension Sympathetic Nervous Activity Verapamil Sr Bisoprolol
刊名HYPERTENSION RESEARCH
2000-09-01
23期:5页:537-540
收录类别ISTP ; SCI
文章类型Proceedings Paper
WOS标题词Science & Technology
类目[WOS]Peripheral Vascular Disease
研究领域[WOS]Cardiovascular System & Cardiology
英文摘要

To assess the response of the sympathetic nervous system (SNS) to the handgrip test in essential hypertensive patients and to evaluate the effects of verapamil SR and bisoprolol on the reduction of the SNS′s activity. Seventy eight essential hypertensive patients (50 receiving verapamil SR treatment and 28 receiving bisoprolol treatment) took the handgrip test while the SEP, DBP, and HR were measured on three occasions during the test (before test, 3 min after the patients squeezed the handgrip, and 2 min after the handgrip was released). Before and after the patients received Verapamil SR or Bisoprolol treatment, the plasma concentrations of epinephrine(E), norepinephrine(NE), angiotensin-ll (All), aldosterone (ALD), endothelin-1 (ET-1) and renin activity (RA) were measured post-test. 1) In about 70% of the essential hypertensive patients, SNS activity was above normal. Their HR and BP exceeded 20% when responding to stress. 2) In these patients, the baseline plasma concentrations of E, NE, All, ET-1, ALD, and RA were higher than those whose SNS′s activity was normal. 3) After 6 weeks of treatment, all the patients′ BPs decreased remarkably. Verapamil SR could reduce the plasma concentrations of NE, Ail, and ET-1 and increase RA, Bisoprolol could reduce E and RA. These two antihypertension drugs can both decrease BP and reduce the activity of SNS through different mechanisms.

语种英语
WOS记录号WOS:000089802100018
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52877
专题北京大学第二临床医学院
作者单位1.Shandong Qilu Shihua Ctr Hosp, Dept Cardiol, Zibo, Peoples R China
2.Peking Univ, Peoples Hosp, Cardiovasc Dept, Beijing 100044, Peoples R China
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GB/T 7714
Sun, NL,Hong, TT,Zhang, RJ,et al. The effects of verapamil SR and bisoprolol on reducing the sympathetic nervous system′s activity[J]. HYPERTENSION RESEARCH,2000,23(5):537-540.
APA Sun, NL,Hong, TT,Zhang, RJ,&Yang, X.(2000).The effects of verapamil SR and bisoprolol on reducing the sympathetic nervous system′s activity.HYPERTENSION RESEARCH,23(5),537-540.
MLA Sun, NL,et al."The effects of verapamil SR and bisoprolol on reducing the sympathetic nervous system′s activity".HYPERTENSION RESEARCH 23.5(2000):537-540.
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