IR@PKUHSC  > 北京大学基础医学院  > 病原生物学系
学科主题基础医学
A water-soluble photocrosslinkable chitosan derivative prepared by Michael-addition reaction as a precursor for injectable hydrogel
Gao, Xuanyue1,2; Zhou, Yingshan1,2; Ma, Guiping1,2; Shi, Suqing3; Yang, Dongzhi1,2; Lu, Fengmin4; Nie, Jun1,2
关键词Chitosan Hydrogel Photopolymerization Water-solubility
刊名CARBOHYDRATE POLYMERS
2010-02-11
DOI10.1016/j.carbpol.2009.08.033
79期:3页:507-512
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Applied ; Chemistry, Organic ; Polymer Science
研究领域[WOS]Chemistry ; Polymer Science
关键词[WOS]DRUG-DELIVERY SYSTEMS ; CHEMICAL-MODIFICATION ; TISSUE ; SCAFFOLDS ; MACROMERS ; BONE
英文摘要

With the goal of obtaining photopolymerized hydrogels for use as tissue engineering scaffolds, a water-soluble (methacryloyloxy) ethyl carboxyethyl chitosan was prepared as a photopolymerizable prepolymer through Michael-addition reaction between chitosan and ethylene glycol acrylate methacrylate. N-substitution of chitosan was verified by both (1)H NMR and (13)C NMR The degree of N-substitution, measured via 1H NMR, was easily varied from 0.10 to 0.35 by varying the molar ratio of ethylene glycol acrylate methacrylate to chitosan. Using a Vero cell line, the water-soluble photocrosslinkable chitosan derivative was found to be noncytotoxic up to a concentration of 1.0 mg/mL. The precursor was blended with D-2959 photoinitiator in solution, and UV-irradiated to create hydrogels. FTIR verified the nearly complete conversion of the double bonds in the gel. Indirect cytotoxicity assessment of the hydrogel indicated that the hydrogel was non-toxic to Vero cells. (C) 2009 Published by Elsevier Ltd.

语种英语
WOS记录号WOS:000273864500003
Citation statistics
Cited Times:36[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52884
Collection北京大学基础医学院_病原生物学系
作者单位1.Northwest Univ, Dept Chem, Xian 710069, Peoples R China
2.Beijing Univ Chem Technol, State Key Lab Chem Resource Engn, Beijing 100029, Peoples R China
3.Beijing Univ Chem Technol, Key Lab Beijing City Preparat & Proc Novel Polyme, Beijing 100029, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Gao, Xuanyue,Zhou, Yingshan,Ma, Guiping,et al. A water-soluble photocrosslinkable chitosan derivative prepared by Michael-addition reaction as a precursor for injectable hydrogel[J]. CARBOHYDRATE POLYMERS,2010,79(3):507-512.
APA Gao, Xuanyue.,Zhou, Yingshan.,Ma, Guiping.,Shi, Suqing.,Yang, Dongzhi.,...&Nie, Jun.(2010).A water-soluble photocrosslinkable chitosan derivative prepared by Michael-addition reaction as a precursor for injectable hydrogel.CARBOHYDRATE POLYMERS,79(3),507-512.
MLA Gao, Xuanyue,et al."A water-soluble photocrosslinkable chitosan derivative prepared by Michael-addition reaction as a precursor for injectable hydrogel".CARBOHYDRATE POLYMERS 79.3(2010):507-512.
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