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学科主题临床医学
Percent free prostate-specific antigen is effective to predict prostate biopsy outcome in Chinese men with prostate-specific antigen between 10.1 and 20.0 ng ml(1)
Chen, Rui1; Zhou, Li-Qun2; Cai, Xiao-Bing3; Xie, Li-Ping4; Huang, Yi-Ran5; He, Da-Lin6; Gao, Xu1; Xu, Chuan-Liang1; Ding, Qiang7; Wei, Qiang8; Yin, Chang-Jun9; Ren, Shan-Cheng1; Wang, Fu-Bo1; Tian, Ye10; Sun, Zhong-Quan11; Fu, Qiang12; Ma, Lu-Lin13; Zheng, Jun-Hua14; Ye, Zhang-Qun15; Ye, Ding-Wei16; Xu, Dan-Feng17; Hou, Jian-Quan18; Xu, Ke-Xin19; Yuan, Jian-Lin20; Gao, Xin21; Liu, Chun-Xiao22; Pan, Tie-Jun23; Sun, Ying-Hao1; Chinese Prostate Canc Consortium1
关键词Chinese Population Diagnosis Percent Free Prostate-specific Antigen Prostate Cancer Prostate Carcinoma Tumor Antigen Prostate-specific Antigen
刊名ASIAN JOURNAL OF ANDROLOGY
2015-11-01
DOI10.4103/1008-682X.150846
17期:6页:1017-1021
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Andrology ; Urology & Nephrology
研究领域[WOS]Endocrinology & Metabolism ; Urology & Nephrology
关键词[WOS]MULTICENTER CLINICAL-TRIAL ; DIGITAL RECTAL EXAMINATION ; GENOME-WIDE ASSOCIATION ; FREE PSA ; CANCER DETECTION ; SERUM-LEVELS ; NG/ML ; METAANALYSIS ; PERFORMANCE ; POPULATION
英文摘要

Percent free prostatic-specific antigen (%fPSA) has been introduced as a tool to avoid unnecessary biopsies in patients with a serum PSA level of 4.0-10.0 ng ml(1) , however, it remains controversial whether %fPSA is effective in PSA range of 10.1-20.0 ng ml(1) in both Chinese and Western population. In this study, the diagnostic performance of %fPSA and serum PSA in predicting prostate cancer (PCa) and high-grade PCa (HGPCa) was analyzed in a multi-center biopsy cohort of 5915 consecutive Chinese patients who underwent prostate biopsy in 22 hospitals across China from January 1, 2010 to December 31, 2013. The indication for biopsy was PSA > 4.0 ng ml(1) or/and suspicious digital rectal examination. Total and free serum PSA determinations were performed by three types of electrochemiluminescence immunoassays with recalibration to the World Health Organization standards. The diagnostics accuracy of PSA, %fPSA and %fPSA in combination with PSA (%fPSA PSA) was determined by the area under the receivers operating characteristic curve (AUC). %fPSA was more effective than PSA in men aged >= 60 years old. The AUC was 0.584 and 0.635 in men aged >= 60 years old with a PSA of 4.0-10.0 ng ml(1) and 10.1-20.0 ng ml(1) , respectively. The AUC of %fPSA was superior to that of PSA in predicting HGPCa in patients >= 60 years old in these two PSA range. Our results indicated that %fPSA is both statistically effective and clinical applicable to predict prostate biopsy outcome in Chinese patients aged >= 60 years old with a PSA of 4.0-10.0 ng ml(1) and 10.1-20.0 ng ml(1) .

语种英语
WOS记录号WOS:000366040100030
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52885
专题北京大学第一临床医学院_泌尿外科
作者单位1.Peking Univ, Hosp 3, Dept Urol, Beijing 100083, Peoples R China
2.Second Mil Med Univ, Shanghai Changhai Hosp, Dept Urol, Shanghai 200433, Peoples R China
3.Peking Univ, Inst Urol, Dept Urol, Hosp 1,Natl Urol Canc Ctr, Beijing 100034, Peoples R China
4.PLA Headquarters Gen Staff Guard Bur, Dept Hlth Care, Beijing 100017, Peoples R China
5.Zhejiang Univ, Sch Med, Dept Urol, Affiliated Hosp 1, Hangzhou 310003, Zhejiang, Peoples R China
6.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Urol, Shanghai 200127, Peoples R China
7.Xi An Jiao Tong Univ, Sch Med, Affiliated Hosp 1, Dept Urol, Xian 710061, Peoples R China
8.Fudan Univ, Huashan Hosp, Dept Urol, Shanghai 200040, Peoples R China
9.Sichuan Univ, West China Hosp, Dept Urol, Chengdu 610041, Sichuan, Peoples R China
10.Nanjing Med Univ, Dept Urol, State Key Lab Reprod Med, Affiliated Hosp 1, Nanjing 210029, Jiangsu, Peoples R China
11.Capital Med Univ, Beijing Friendship Hosp, Dept Urol, Beijing 100050, Peoples R China
12.Fudan Univ, Huadong Hosp, Dept Urol, Shanghai 20040, Peoples R China
13.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Urol, Shanghai 200233, Peoples R China
14.Tongji Univ, Peoples Hosp 10, Dept Urol, Shanghai 200072, Peoples R China
15.Huazhong Univ Sci & Technol, Tongji Hosp, Dept Urol, Tongji Med Coll, Wuhan 430030, Peoples R China
16.Fudan Univ, Dept Oncol, Shanghai Canc Ctr, Shanghai 200032, Peoples R China
17.Second Mil Med Univ, Shanghai Changzheng Hosp, Dept Urol, Shanghai 200003, Peoples R China
18.Soochow Univ, Affiliated Hosp 1, Dept Urol, Suzhou 215006, Peoples R China
19.Peking Univ, Peoples Hosp, Dept Urol, Beijing 100044, Peoples R China
20.Fourth Mil Med Univ, Xijing Hosp, Dept Urol, Xian 710032, Peoples R China
21.Sun Yat Sen Univ, Hosp 3, Dept Urol, Guangzhou 510630, Guangdong, Peoples R China
22.Southern Med Univ, Zhujiang Hosp, Dept Urol, Guangzhou 510282, Guangdong, Peoples R China
23.Guangzhou Mil Command, Wuhan Gen Hosp, Dept Urol, Wuhan 430070, Peoples R China
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Chen, Rui,Zhou, Li-Qun,Cai, Xiao-Bing,et al. Percent free prostate-specific antigen is effective to predict prostate biopsy outcome in Chinese men with prostate-specific antigen between 10.1 and 20.0 ng ml(1)[J]. ASIAN JOURNAL OF ANDROLOGY,2015,17(6):1017-1021.
APA Chen, Rui.,Zhou, Li-Qun.,Cai, Xiao-Bing.,Xie, Li-Ping.,Huang, Yi-Ran.,...&Chinese Prostate Canc Consortium.(2015).Percent free prostate-specific antigen is effective to predict prostate biopsy outcome in Chinese men with prostate-specific antigen between 10.1 and 20.0 ng ml(1).ASIAN JOURNAL OF ANDROLOGY,17(6),1017-1021.
MLA Chen, Rui,et al."Percent free prostate-specific antigen is effective to predict prostate biopsy outcome in Chinese men with prostate-specific antigen between 10.1 and 20.0 ng ml(1)".ASIAN JOURNAL OF ANDROLOGY 17.6(2015):1017-1021.
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