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C-mos immunoreactivity aids in the diagnosis of gestational trophoblastic lesions
Xue, WC1; Khoo, US1; Ngan, HYS1; Chan, KYK1; Ip, PPC1; Tsao, SW1; Cheung, ANY1
关键词C-mos Gestational Trophoblastic Disease Hydatidiform Mole Choriocarcinoma Gynecological Neoplasm Germ Cell Tumor
刊名INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY
2004-04-01
DOI10.1097/01.pgp.0000116626.23685.fb
23期:2页:145-150
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Obstetrics & Gynecology ; Pathology
研究领域[WOS]Obstetrics & Gynecology ; Pathology
关键词[WOS]INTERMEDIATE TROPHOBLAST ; ONCOGENE PRODUCT ; MUTATION ANALYSIS ; SOMATIC-CELLS ; P53 GENE ; EXPRESSION ; PROTOONCOGENE ; APOPTOSIS ; CARCINOMA ; DISEASE
英文摘要

C-mos is an important proto-oncogene involved in the mitogen-activating protein kinase pathway. This study was designed to explore c-mos immunoreactivity in gestational trophoblastic lesions and compare it with immunoreactivity in normal placentas as well as other gynecological lesions and germ cell tumors using antibody P-19. The immunohistochemical distribution of c-mos in 159 cases of gynecological lesions and 26 germ cell tumors using formalin-fixed, paraffin-embedded tissues was evaluated. The lesions included 45 (32 complete and 13 partial) hydatidiform moles, 17 choriocarcinomas, 5 placental site trophoblastic tumors, 18 squamous cell carcinomas and 5 adenocarcinomas of the cervix, 11 endometrial carcinomas, 9 ovarian carcinomas, 4 primary peritoneal papillary serous carcinomas, 9 low-grade endometrial stromal sarcomas, 4 epithelioid leiomyomas, 6 leiomyosarcomas, and 26 gem cell tumors (3 embryonal carcinomas, 5 yolk sac tumors, 6 immature teratomas, and 3 mature teratomas from the ovary; 9 testicular seminomas). Twenty-six normal placentas also were included for comparison. Among cases of gestational trophoblastic diseases, c-mos immunoreactivity was found in all hydatidiform moles and choriocarcinomas, but in none of the placental site trophoblastic tumors. The c-mos staining pattern was similar in trophoblastic diseases and normal placentas with strong expression in syncytiotrophoblast, moderate expression in villous intermediate trophoblast, and predominantly negative expression in implantation site intermediate trophoblast, chorionic-type intermediate trophoblast, and villous cytotrophoblast. All the nontrophoblastic tumors, including carcinomas, sarcomas, and germ cell tumors, were negative for c-mos expression. Immunohistochemical detection of c-mos is useful in differentiating choriocarcinoma from placental site trophoblastic tumor and nontrophoblastic tumors of the female genital tract that may sometimes cause problems in differential diagnosis.

语种英语
WOS记录号WOS:000220452800009
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被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52886
专题北京大学第二临床医学院_病理科
作者单位1.Univ Hong Kong, Queen Mary Hosp, Dept Pathol, Hong Kong, Hong Kong, Peoples R China
2.Univ Hong Kong, Queen Mary Hosp, Dept Obstet & Gynecol, Hong Kong, Hong Kong, Peoples R China
3.Univ Hong Kong, Dept Anat, Hong Kong, Hong Kong, Peoples R China
4.Peking Univ, Peoples Hosp, Dept Pathol, Beijing 100871, Peoples R China
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Xue, WC,Khoo, US,Ngan, HYS,et al. C-mos immunoreactivity aids in the diagnosis of gestational trophoblastic lesions[J]. INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY,2004,23(2):145-150.
APA Xue, WC.,Khoo, US.,Ngan, HYS.,Chan, KYK.,Ip, PPC.,...&Cheung, ANY.(2004).C-mos immunoreactivity aids in the diagnosis of gestational trophoblastic lesions.INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY,23(2),145-150.
MLA Xue, WC,et al."C-mos immunoreactivity aids in the diagnosis of gestational trophoblastic lesions".INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY 23.2(2004):145-150.
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