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学科主题: 临床医学
题名:
C-mos immunoreactivity aids in the diagnosis of gestational trophoblastic lesions
作者: Xue, WC1; Khoo, US1; Ngan, HYS1; Chan, KYK1; Ip, PPC1; Tsao, SW1; Cheung, ANY1
关键词: c-mos ; gestational trophoblastic disease ; hydatidiform mole ; choriocarcinoma ; gynecological neoplasm ; germ cell tumor
刊名: INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY
发表日期: 2004-04-01
DOI: 10.1097/01.pgp.0000116626.23685.fb
卷: 23, 期:2, 页:145-150
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Obstetrics & Gynecology ; Pathology
研究领域[WOS]: Obstetrics & Gynecology ; Pathology
关键词[WOS]: INTERMEDIATE TROPHOBLAST ; ONCOGENE PRODUCT ; MUTATION ANALYSIS ; SOMATIC-CELLS ; P53 GENE ; EXPRESSION ; PROTOONCOGENE ; APOPTOSIS ; CARCINOMA ; DISEASE
英文摘要:

C-mos is an important proto-oncogene involved in the mitogen-activating protein kinase pathway. This study was designed to explore c-mos immunoreactivity in gestational trophoblastic lesions and compare it with immunoreactivity in normal placentas as well as other gynecological lesions and germ cell tumors using antibody P-19. The immunohistochemical distribution of c-mos in 159 cases of gynecological lesions and 26 germ cell tumors using formalin-fixed, paraffin-embedded tissues was evaluated. The lesions included 45 (32 complete and 13 partial) hydatidiform moles, 17 choriocarcinomas, 5 placental site trophoblastic tumors, 18 squamous cell carcinomas and 5 adenocarcinomas of the cervix, 11 endometrial carcinomas, 9 ovarian carcinomas, 4 primary peritoneal papillary serous carcinomas, 9 low-grade endometrial stromal sarcomas, 4 epithelioid leiomyomas, 6 leiomyosarcomas, and 26 gem cell tumors (3 embryonal carcinomas, 5 yolk sac tumors, 6 immature teratomas, and 3 mature teratomas from the ovary; 9 testicular seminomas). Twenty-six normal placentas also were included for comparison. Among cases of gestational trophoblastic diseases, c-mos immunoreactivity was found in all hydatidiform moles and choriocarcinomas, but in none of the placental site trophoblastic tumors. The c-mos staining pattern was similar in trophoblastic diseases and normal placentas with strong expression in syncytiotrophoblast, moderate expression in villous intermediate trophoblast, and predominantly negative expression in implantation site intermediate trophoblast, chorionic-type intermediate trophoblast, and villous cytotrophoblast. All the nontrophoblastic tumors, including carcinomas, sarcomas, and germ cell tumors, were negative for c-mos expression. Immunohistochemical detection of c-mos is useful in differentiating choriocarcinoma from placental site trophoblastic tumor and nontrophoblastic tumors of the female genital tract that may sometimes cause problems in differential diagnosis.

语种: 英语
WOS记录号: WOS:000220452800009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52886
Appears in Collections:北京大学第二临床医学院_病理科_期刊论文

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作者单位: 1.Univ Hong Kong, Queen Mary Hosp, Dept Pathol, Hong Kong, Hong Kong, Peoples R China
2.Univ Hong Kong, Queen Mary Hosp, Dept Obstet & Gynecol, Hong Kong, Hong Kong, Peoples R China
3.Univ Hong Kong, Dept Anat, Hong Kong, Hong Kong, Peoples R China
4.Peking Univ, Peoples Hosp, Dept Pathol, Beijing 100871, Peoples R China

Recommended Citation:
Xue, WC,Khoo, US,Ngan, HYS,et al. C-mos immunoreactivity aids in the diagnosis of gestational trophoblastic lesions[J]. INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY,2004,23(2):145-150.
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