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The utility of amplitude-integrated EEG and NIRS measurements as indices of hypoxic ischaemia in the newborn pig
Zhang, Dandan2,3; Hou, Xinlin1; Liu, Yunfeng4; Zhou, Congle1; Luo, Yuejia2; Ding, Haiyan3
关键词Amplitude-integrated Electroencephalogram Near-infrared Spectroscopy Hypoxic Ischaemia Sensitivity Correlation
刊名CLINICAL NEUROPHYSIOLOGY
2012-08-01
DOI10.1016/j.clinph.2011.10.051
123期:8页:1668-1675
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology ; Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]NEAR-INFRARED SPECTROSCOPY ; CEREBRAL OXYGEN-SATURATION ; ENCEPHALOPATHY ; ELECTROENCEPHALOGRAPHY ; INFANTS ; PIGLETS ; TISSUE ; HEMODYNAMICS ; INJURY ; REPERFUSION
英文摘要

Objective: The early detection and stratification of potential hypoxic ischaemia (HI) injury in neonates are crucial for reducing the risk of neural disability. This study investigates early changes in brain function caused by acute HI of varying severities in the neonatal pig.

Methods: Two non-invasive techniques, amplitude-integrated electroencephalogram (aEEG) and near-infrared spectroscopy (NIRS), were used to monitor electrocortical and cerebral haemodynamic function, respectively. The fraction of inspired oxygen (FiO(2)) was varied to produce different HI severities. The sensitivity and HI correlation of these methods were systematically analysed to assess their abilities to both detect injury early and assess HI severity accurately.

Results: The tissue oxygen index measured via NIRS detected acute changes in cerebral oxygenation and was highly sensitive to HI (sensitivity = 0.97), whereas aEEG was comparatively insensitive to HI. On the other hand, aEEG measurements correlated well with FiO(2) during the entire HI event as well as the 3-h recovery period (R = 0.43-0.61). NIRS measurements did not correlate well with FiO(2).

Conclusions: Parameters measured via aEEG and NIRS displayed different time profiles during and following the HI event.

Significance: These results highlight the potential advantage of using aEEG and NIRS in conjunction to monitor neonatal brain function, and provide an objective and rigorous method for the characterisation of cerebral function both during and following HI insults. (C) 2011 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000306108000029
项目编号30930031 ; 200800011071
资助机构Tsinghua-Yue-Yuen Medical Sciences Fund ; National Natural Science Foundation of China ; Chinese Ministry of Education Foundation for Core Young Teachers at University
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52891
专题北京大学第一临床医学院_儿科
北京大学第三临床医学院_儿科
作者单位1.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
2.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
3.Tsinghua Univ, Dept Biomed Engn, Beijing 100084, Peoples R China
4.Peking Univ, Hosp 3, Dept Pediat, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Dandan,Hou, Xinlin,Liu, Yunfeng,et al. The utility of amplitude-integrated EEG and NIRS measurements as indices of hypoxic ischaemia in the newborn pig[J]. CLINICAL NEUROPHYSIOLOGY,2012,123(8):1668-1675.
APA Zhang, Dandan,Hou, Xinlin,Liu, Yunfeng,Zhou, Congle,Luo, Yuejia,&Ding, Haiyan.(2012).The utility of amplitude-integrated EEG and NIRS measurements as indices of hypoxic ischaemia in the newborn pig.CLINICAL NEUROPHYSIOLOGY,123(8),1668-1675.
MLA Zhang, Dandan,et al."The utility of amplitude-integrated EEG and NIRS measurements as indices of hypoxic ischaemia in the newborn pig".CLINICAL NEUROPHYSIOLOGY 123.8(2012):1668-1675.
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