|The utility of amplitude-integrated EEG and NIRS measurements as indices of hypoxic ischaemia in the newborn pig|
|Zhang, Dandan2,3; Hou, Xinlin1; Liu, Yunfeng4; Zhou, Congle1; Luo, Yuejia2; Ding, Haiyan3|
|关键词||Amplitude-integrated Electroencephalogram Near-infrared Spectroscopy Hypoxic Ischaemia Sensitivity Correlation|
|WOS标题词||Science & Technology|
|类目[WOS]||Clinical Neurology ; Neurosciences|
|研究领域[WOS]||Neurosciences & Neurology|
|关键词[WOS]||NEAR-INFRARED SPECTROSCOPY ; CEREBRAL OXYGEN-SATURATION ; ENCEPHALOPATHY ; ELECTROENCEPHALOGRAPHY ; INFANTS ; PIGLETS ; TISSUE ; HEMODYNAMICS ; INJURY ; REPERFUSION|
Objective: The early detection and stratification of potential hypoxic ischaemia (HI) injury in neonates are crucial for reducing the risk of neural disability. This study investigates early changes in brain function caused by acute HI of varying severities in the neonatal pig.
Methods: Two non-invasive techniques, amplitude-integrated electroencephalogram (aEEG) and near-infrared spectroscopy (NIRS), were used to monitor electrocortical and cerebral haemodynamic function, respectively. The fraction of inspired oxygen (FiO(2)) was varied to produce different HI severities. The sensitivity and HI correlation of these methods were systematically analysed to assess their abilities to both detect injury early and assess HI severity accurately.
Results: The tissue oxygen index measured via NIRS detected acute changes in cerebral oxygenation and was highly sensitive to HI (sensitivity = 0.97), whereas aEEG was comparatively insensitive to HI. On the other hand, aEEG measurements correlated well with FiO(2) during the entire HI event as well as the 3-h recovery period (R = 0.43-0.61). NIRS measurements did not correlate well with FiO(2).
Conclusions: Parameters measured via aEEG and NIRS displayed different time profiles during and following the HI event.
Significance: These results highlight the potential advantage of using aEEG and NIRS in conjunction to monitor neonatal brain function, and provide an objective and rigorous method for the characterisation of cerebral function both during and following HI insults. (C) 2011 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
|项目编号||30930031 ; 200800011071|
|资助机构||Tsinghua-Yue-Yuen Medical Sciences Fund ; National Natural Science Foundation of China ; Chinese Ministry of Education Foundation for Core Young Teachers at University|
|作者单位||1.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China|
2.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
3.Tsinghua Univ, Dept Biomed Engn, Beijing 100084, Peoples R China
4.Peking Univ, Hosp 3, Dept Pediat, Beijing 100034, Peoples R China
|Zhang, Dandan,Hou, Xinlin,Liu, Yunfeng,et al. The utility of amplitude-integrated EEG and NIRS measurements as indices of hypoxic ischaemia in the newborn pig[J]. CLINICAL NEUROPHYSIOLOGY,2012,123(8):1668-1675.|
|APA||Zhang, Dandan,Hou, Xinlin,Liu, Yunfeng,Zhou, Congle,Luo, Yuejia,&Ding, Haiyan.(2012).The utility of amplitude-integrated EEG and NIRS measurements as indices of hypoxic ischaemia in the newborn pig.CLINICAL NEUROPHYSIOLOGY,123(8),1668-1675.|
|MLA||Zhang, Dandan,et al."The utility of amplitude-integrated EEG and NIRS measurements as indices of hypoxic ischaemia in the newborn pig".CLINICAL NEUROPHYSIOLOGY 123.8(2012):1668-1675.|