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学科主题: 临床医学
题名:
A near infrared fluorescent/ultrasonic bimodal contrast agent for imaging guided pDNA delivery via ultrasound targeted microbubble destruction
作者: Yang, Yongbo2; Wang, Jinrui3; Li, Xiaoda2; Lin, Li2; Yue, Xiuli1
刊名: RSC ADVANCES
发表日期: 2015
DOI: 10.1039/c4ra15066j
卷: 5, 期:11, 页:8404-8414
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: SEMICONDUCTOR QUANTUM DOTS ; IN-VIVO ; GENE DELIVERY ; PHOTOTHERMAL THERAPY ; SIRNA DELIVERY ; NANOPARTICLES ; POLYETHYLENIMINE ; NANOCRYSTALS ; TRANSFECTION ; EFFICIENCY
英文摘要:

This paper reported the development of a multifunctional contrast agent for near infrared (NIR) fluorescent/ultrasonic bimodal imaging and gene delivery. CuInS2-ZnS alloyed quantum dots (ZCIS QDs) were coated with polyethyleneimine (PEI) to complex plasmid DNA (pDNA), followed by adsorption onto the surface of microbubbles (MBs) generated from the surfactant mixture of Span 60 and Tween 80. It was found that the obtained composite agent of MBs@QDs@PEI/pDNA had excellent capability to enhance both ultrasound and fluorescence imaging. In addition, an in vitro cell experiment showed that pDNA could be released from MBs@QDs@PEI/pDNA and internalized by target HeLa cells to realize a relatively high transfection efficiency by ultrasound-targeted microbubble destruction. Furthermore, the cytotoxicity, immune toxicity and histological evaluation showed that MBs@QDs@PEI/pDNA had a good biocompatibility for medical application. Therefore, such a multifunction agent could operate as a promising platform for targeting gene delivery under the guidance of NIR fluorescent/ultrasonic bimodal imaging.

语种: 英语
所属项目编号: 81371580 ; 81171347 ; 81230036
项目资助者: National Natural Science Foundation of China ; State Key Program of National Natural Science of China
WOS记录号: WOS:000347720900084
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52901
Appears in Collections:北京大学第三临床医学院_超声诊断科_期刊论文

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作者单位: 1.Harbin Inst Technol, Sch Municipal & Environm Engn, Harbin 150001, Peoples R China
2.Harbin Inst Technol, Sch Life Sci & Technol, Harbin 150001, Peoples R China
3.Peking Univ, Hosp 3, Dept Ultrasonog, Beijing 100083, Peoples R China

Recommended Citation:
Yang, Yongbo,Wang, Jinrui,Li, Xiaoda,et al. A near infrared fluorescent/ultrasonic bimodal contrast agent for imaging guided pDNA delivery via ultrasound targeted microbubble destruction[J]. RSC ADVANCES,2015,5(11):8404-8414.
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