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学科主题临床医学
A near infrared fluorescent/ultrasonic bimodal contrast agent for imaging guided pDNA delivery via ultrasound targeted microbubble destruction
Yang, Yongbo2; Wang, Jinrui3; Li, Xiaoda2; Lin, Li2; Yue, Xiuli1
刊名RSC ADVANCES
2015
DOI10.1039/c4ra15066j
5期:11页:8404-8414
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]SEMICONDUCTOR QUANTUM DOTS ; IN-VIVO ; GENE DELIVERY ; PHOTOTHERMAL THERAPY ; SIRNA DELIVERY ; NANOPARTICLES ; POLYETHYLENIMINE ; NANOCRYSTALS ; TRANSFECTION ; EFFICIENCY
英文摘要

This paper reported the development of a multifunctional contrast agent for near infrared (NIR) fluorescent/ultrasonic bimodal imaging and gene delivery. CuInS2-ZnS alloyed quantum dots (ZCIS QDs) were coated with polyethyleneimine (PEI) to complex plasmid DNA (pDNA), followed by adsorption onto the surface of microbubbles (MBs) generated from the surfactant mixture of Span 60 and Tween 80. It was found that the obtained composite agent of MBs@QDs@PEI/pDNA had excellent capability to enhance both ultrasound and fluorescence imaging. In addition, an in vitro cell experiment showed that pDNA could be released from MBs@QDs@PEI/pDNA and internalized by target HeLa cells to realize a relatively high transfection efficiency by ultrasound-targeted microbubble destruction. Furthermore, the cytotoxicity, immune toxicity and histological evaluation showed that MBs@QDs@PEI/pDNA had a good biocompatibility for medical application. Therefore, such a multifunction agent could operate as a promising platform for targeting gene delivery under the guidance of NIR fluorescent/ultrasonic bimodal imaging.

语种英语
WOS记录号WOS:000347720900084
项目编号81371580 ; 81171347 ; 81230036
资助机构National Natural Science Foundation of China ; State Key Program of National Natural Science of China
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52901
专题北京大学第三临床医学院_超声诊断科
作者单位1.Harbin Inst Technol, Sch Municipal & Environm Engn, Harbin 150001, Peoples R China
2.Harbin Inst Technol, Sch Life Sci & Technol, Harbin 150001, Peoples R China
3.Peking Univ, Hosp 3, Dept Ultrasonog, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Yang, Yongbo,Wang, Jinrui,Li, Xiaoda,et al. A near infrared fluorescent/ultrasonic bimodal contrast agent for imaging guided pDNA delivery via ultrasound targeted microbubble destruction[J]. RSC ADVANCES,2015,5(11):8404-8414.
APA Yang, Yongbo,Wang, Jinrui,Li, Xiaoda,Lin, Li,&Yue, Xiuli.(2015).A near infrared fluorescent/ultrasonic bimodal contrast agent for imaging guided pDNA delivery via ultrasound targeted microbubble destruction.RSC ADVANCES,5(11),8404-8414.
MLA Yang, Yongbo,et al."A near infrared fluorescent/ultrasonic bimodal contrast agent for imaging guided pDNA delivery via ultrasound targeted microbubble destruction".RSC ADVANCES 5.11(2015):8404-8414.
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