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Efficacy of Levetiracetam in Electrical Status Epilepticus During Sleep of Children: A Multicenter Experience
Chen, Xiao-Qiao1; Zhang, Wei-Na1; Yang, Zhi-Xian2; Zhao, Meng1; Cal, Fang-Cheng3; Huang, Shao-Ping4; Gao, Li5; Pang, Bao-Dong6; Chen, Xi7; Zou, Li-Ping1
关键词Electrical Status Epilepticus During Sleep Levetiracetam Children Idiopathic Symptomatic Treatment
刊名PEDIATRIC NEUROLOGY
2014-03-01
DOI10.1016/j.pediatrneurol.2013.10.015
50期:3页:243-249
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology ; Pediatrics
研究领域[WOS]Neurosciences & Neurology ; Pediatrics
关键词[WOS]LANDAU-KLEFFNER SYNDROME ; SLOW-WAVE SLEEP ; CONTINUOUS SPIKES ; ADJUNCTIVE LEVETIRACETAM ; ESES SYNDROME ; DOUBLE-BLIND ; EPILEPSY ; ENCEPHALOPATHY ; SEIZURES ; EEG
英文摘要

BACKGROUND: Electrical status epilepticus during sleep is characterized by epilepsy, a specific electroencephalographic pattern, and neuropsychological impairment. This study aims to evaluate the efficacy and safety of levetiracetam in treating children with electrical status epilepticus during sleep. METHODS: A multicenter, retrospective, open-label study enrolled 73 children (mean age: 8 years) affected by electrical status epilepticus during sleep. The efficacy was rated according to the seizure frequency and electroencephalography response. RESULTS: After a mean treatment period of 19 months (range: 6 to 24 months), 33 (63.5%) of 52 patients became seizure-free or had experienced remarkable reduction in seizures. The electrical status epilepticus of 41(56.2%) of 73 patients disappeared off their electroencephalography. The electroencephalography efficacy of levetiracetam treatment was noted in the monotherapy (61.9%) and add-on (53.9%) groups. The clinical (67.7%) and electroencephalography (64.3%) response rates of the idiopathic group were better than those of the symptomatic group (57.1% and 45.2%, respectively). No patient discontinued the trial because of intolerability of side effects. CONCLUSIONS: Levetiracetam is effective in individuals with electrical status epilepticus during sleep with tolerable side effects.

语种英语
WOS记录号WOS:000332056300009
项目编号30801249 ; 30770747 ; 81071055 ; 7042024 ; 7081002 ; 2012CB517903 ; BIBD-PXM2013_014226_07_000084
资助机构National Natural Science Foundation of China ; Natural Science Foundation of Beijing ; National Basic Research Program of China (973) ; Peking-Tsinghua Center for Life Sciences and Center of Epilepsy ; Beijing Institute for Brain Disorders
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52915
专题北京大学第一临床医学院_儿科
作者单位1.Chinese Peoples Liberat Army Gen Hosp, Dept Pediat, Beijing 100853, Peoples R China
2.Peking Univ, Hosp 1, Dept Pediat, Beijing 100871, Peoples R China
3.Chongqing Med Univ, Childrens Hosp, Dept Neurol, Chongqing, Peoples R China
4.Xi An Jiao Tong Univ, Affiliated Hosp 2, Coll Med, Dept Pediat, Xian 710049, Peoples R China
5.Henan Prov Peoples Hosp, Dept Pediat, Zhengzhou, Peoples R China
6.Tangshan Maternal & Hlth Care Hosp, Dept Pediat, Tangshan, Peoples R China
7.Urumqi Childrens Hosp, Dept Neurol, Urumqi, Peoples R China
推荐引用方式
GB/T 7714
Chen, Xiao-Qiao,Zhang, Wei-Na,Yang, Zhi-Xian,et al. Efficacy of Levetiracetam in Electrical Status Epilepticus During Sleep of Children: A Multicenter Experience[J]. PEDIATRIC NEUROLOGY,2014,50(3):243-249.
APA Chen, Xiao-Qiao.,Zhang, Wei-Na.,Yang, Zhi-Xian.,Zhao, Meng.,Cal, Fang-Cheng.,...&Zou, Li-Ping.(2014).Efficacy of Levetiracetam in Electrical Status Epilepticus During Sleep of Children: A Multicenter Experience.PEDIATRIC NEUROLOGY,50(3),243-249.
MLA Chen, Xiao-Qiao,et al."Efficacy of Levetiracetam in Electrical Status Epilepticus During Sleep of Children: A Multicenter Experience".PEDIATRIC NEUROLOGY 50.3(2014):243-249.
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