北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 儿科  > 期刊论文
学科主题: 临床医学
题名:
Efficacy of Levetiracetam in Electrical Status Epilepticus During Sleep of Children: A Multicenter Experience
作者: Chen, Xiao-Qiao1; Zhang, Wei-Na1; Yang, Zhi-Xian2; Zhao, Meng1; Cal, Fang-Cheng3; Huang, Shao-Ping4; Gao, Li5; Pang, Bao-Dong6; Chen, Xi7; Zou, Li-Ping1
关键词: electrical status epilepticus during sleep ; levetiracetam ; children ; idiopathic ; symptomatic ; treatment
刊名: PEDIATRIC NEUROLOGY
发表日期: 2014-03-01
DOI: 10.1016/j.pediatrneurol.2013.10.015
卷: 50, 期:3, 页:243-249
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Pediatrics
研究领域[WOS]: Neurosciences & Neurology ; Pediatrics
关键词[WOS]: LANDAU-KLEFFNER SYNDROME ; SLOW-WAVE SLEEP ; CONTINUOUS SPIKES ; ADJUNCTIVE LEVETIRACETAM ; ESES SYNDROME ; DOUBLE-BLIND ; EPILEPSY ; ENCEPHALOPATHY ; SEIZURES ; EEG
英文摘要:

BACKGROUND: Electrical status epilepticus during sleep is characterized by epilepsy, a specific electroencephalographic pattern, and neuropsychological impairment. This study aims to evaluate the efficacy and safety of levetiracetam in treating children with electrical status epilepticus during sleep. METHODS: A multicenter, retrospective, open-label study enrolled 73 children (mean age: 8 years) affected by electrical status epilepticus during sleep. The efficacy was rated according to the seizure frequency and electroencephalography response. RESULTS: After a mean treatment period of 19 months (range: 6 to 24 months), 33 (63.5%) of 52 patients became seizure-free or had experienced remarkable reduction in seizures. The electrical status epilepticus of 41(56.2%) of 73 patients disappeared off their electroencephalography. The electroencephalography efficacy of levetiracetam treatment was noted in the monotherapy (61.9%) and add-on (53.9%) groups. The clinical (67.7%) and electroencephalography (64.3%) response rates of the idiopathic group were better than those of the symptomatic group (57.1% and 45.2%, respectively). No patient discontinued the trial because of intolerability of side effects. CONCLUSIONS: Levetiracetam is effective in individuals with electrical status epilepticus during sleep with tolerable side effects.

语种: 英语
所属项目编号: 30801249 ; 30770747 ; 81071055 ; 7042024 ; 7081002 ; 2012CB517903 ; BIBD-PXM2013_014226_07_000084
项目资助者: National Natural Science Foundation of China ; Natural Science Foundation of Beijing ; National Basic Research Program of China (973) ; Peking-Tsinghua Center for Life Sciences and Center of Epilepsy ; Beijing Institute for Brain Disorders
WOS记录号: WOS:000332056300009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52915
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Chinese Peoples Liberat Army Gen Hosp, Dept Pediat, Beijing 100853, Peoples R China
2.Peking Univ, Hosp 1, Dept Pediat, Beijing 100871, Peoples R China
3.Chongqing Med Univ, Childrens Hosp, Dept Neurol, Chongqing, Peoples R China
4.Xi An Jiao Tong Univ, Affiliated Hosp 2, Coll Med, Dept Pediat, Xian 710049, Peoples R China
5.Henan Prov Peoples Hosp, Dept Pediat, Zhengzhou, Peoples R China
6.Tangshan Maternal & Hlth Care Hosp, Dept Pediat, Tangshan, Peoples R China
7.Urumqi Childrens Hosp, Dept Neurol, Urumqi, Peoples R China

Recommended Citation:
Chen, Xiao-Qiao,Zhang, Wei-Na,Yang, Zhi-Xian,et al. Efficacy of Levetiracetam in Electrical Status Epilepticus During Sleep of Children: A Multicenter Experience[J]. PEDIATRIC NEUROLOGY,2014,50(3):243-249.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Chen, Xiao-Qiao]'s Articles
[Zhang, Wei-Na]'s Articles
[Yang, Zhi-Xian]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Chen, Xiao-Qiao]‘s Articles
[Zhang, Wei-Na]‘s Articles
[Yang, Zhi-Xian]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace