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学科主题: 基础医学
题名:
Caffeic acid phenethyl ester prevents cerebellar granule neurons (CGNs) against glutamate-induced neurotoxicity
作者: Wei, X.1; Ma, Z.2; Fontanilla, C. V.1; Zhao, L.1; Xu, Z. C.3; Taggliabraci, V.1; Johnstone, B. H.4; Dodel, R. C.1; Farlow, M. R.1; Du, Y.1
关键词: neuron ; CAPE ; neuroprotection ; glutamate ; p38 ; caspase 3
刊名: NEUROSCIENCE
发表日期: 2008-09-09
DOI: 10.1016/j.neuroscience.2008.06.056
卷: 155, 期:4, 页:1098-1105
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: CYTOCHROME-C RELEASE ; PRIMARY CORTICAL-NEURONS ; ISCHEMIC BRAIN-INJURY ; N-TERMINAL KINASE ; CELL-DEATH ; APOPTOSIS ; MITOCHONDRIAL ; ACTIVATION ; TOXICITY ; CAPE
英文摘要:

Caffeic acid phenethyl ester (CAPE) is an active component of propolis obtained from honeybee hives and is found to have the following properties: anti-mitogenic, anticarcinogenic, anti-inflammatory, immunomodulatory, and antioxidant. Recent reports suggest that CAPE also has a neuronal protective property against ischemic injury. Since excitotoxicity may play an important role in ischemia, in this study, we investigated whether CAPE could directly protect neurons against excitotoxic insult. We treated cultured rat cerebellar granule neurons (CGNs) with excitotoxic concentrations of glutamate in the presence or absence of CAPE and found that CAPE markedly protected neurons against glutamate-induced neuronal death in a concentration-dependent fashion. Glutamate-induced CGNs death is associated with time-dependent activation of caspase-3 and phosphorylation of p38, both events of which can be blocked by CAPE. Treating CGNs with specific inhibitors of these two enzymes together exerts a synergistic neuroprotective effect, similar to the neuroprotective effect of CAPE exposure. These results suggest that CAPE is able to block glutamate-induced excitotoxicity by inhibiting phosphorylation of p38 and caspase-3 activation. This finding may further help understanding of the mechanism of glutamate-induced neuronal death and CAPE-induced neuroprotection against excitotoxicity. (C) 2008 IBRO. Published by Elsevier Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000259213200008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52916
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Indiana Univ, Sch Med, Dept Neurol, Indianapolis, IN 46202 USA
2.Peking Univ, Basic Med Sch, Beijing 100871, Peoples R China
3.Indiana Univ, Sch Med, Dept Anat & Cell Biol, Indianapolis, IN 46202 USA
4.Indiana Univ, Sch Med, Dept Med, Indianapolis, IN 46202 USA

Recommended Citation:
Wei, X.,Ma, Z.,Fontanilla, C. V.,et al. Caffeic acid phenethyl ester prevents cerebellar granule neurons (CGNs) against glutamate-induced neurotoxicity[J]. NEUROSCIENCE,2008,155(4):1098-1105.
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