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Caffeic acid phenethyl ester prevents cerebellar granule neurons (CGNs) against glutamate-induced neurotoxicity
Wei, X.1; Ma, Z.2; Fontanilla, C. V.1; Zhao, L.1; Xu, Z. C.3; Taggliabraci, V.1; Johnstone, B. H.4; Dodel, R. C.1; Farlow, M. R.1; Du, Y.1
关键词Neuron Cape Neuroprotection Glutamate P38 Caspase 3
刊名NEUROSCIENCE
2008-09-09
DOI10.1016/j.neuroscience.2008.06.056
155期:4页:1098-1105
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]CYTOCHROME-C RELEASE ; PRIMARY CORTICAL-NEURONS ; ISCHEMIC BRAIN-INJURY ; N-TERMINAL KINASE ; CELL-DEATH ; APOPTOSIS ; MITOCHONDRIAL ; ACTIVATION ; TOXICITY ; CAPE
英文摘要

Caffeic acid phenethyl ester (CAPE) is an active component of propolis obtained from honeybee hives and is found to have the following properties: anti-mitogenic, anticarcinogenic, anti-inflammatory, immunomodulatory, and antioxidant. Recent reports suggest that CAPE also has a neuronal protective property against ischemic injury. Since excitotoxicity may play an important role in ischemia, in this study, we investigated whether CAPE could directly protect neurons against excitotoxic insult. We treated cultured rat cerebellar granule neurons (CGNs) with excitotoxic concentrations of glutamate in the presence or absence of CAPE and found that CAPE markedly protected neurons against glutamate-induced neuronal death in a concentration-dependent fashion. Glutamate-induced CGNs death is associated with time-dependent activation of caspase-3 and phosphorylation of p38, both events of which can be blocked by CAPE. Treating CGNs with specific inhibitors of these two enzymes together exerts a synergistic neuroprotective effect, similar to the neuroprotective effect of CAPE exposure. These results suggest that CAPE is able to block glutamate-induced excitotoxicity by inhibiting phosphorylation of p38 and caspase-3 activation. This finding may further help understanding of the mechanism of glutamate-induced neuronal death and CAPE-induced neuroprotection against excitotoxicity. (C) 2008 IBRO. Published by Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000259213200008
引用统计
被引频次:33[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52916
专题北京大学基础医学院
作者单位1.Indiana Univ, Sch Med, Dept Neurol, Indianapolis, IN 46202 USA
2.Peking Univ, Basic Med Sch, Beijing 100871, Peoples R China
3.Indiana Univ, Sch Med, Dept Anat & Cell Biol, Indianapolis, IN 46202 USA
4.Indiana Univ, Sch Med, Dept Med, Indianapolis, IN 46202 USA
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GB/T 7714
Wei, X.,Ma, Z.,Fontanilla, C. V.,et al. Caffeic acid phenethyl ester prevents cerebellar granule neurons (CGNs) against glutamate-induced neurotoxicity[J]. NEUROSCIENCE,2008,155(4):1098-1105.
APA Wei, X..,Ma, Z..,Fontanilla, C. V..,Zhao, L..,Xu, Z. C..,...&Du, Y..(2008).Caffeic acid phenethyl ester prevents cerebellar granule neurons (CGNs) against glutamate-induced neurotoxicity.NEUROSCIENCE,155(4),1098-1105.
MLA Wei, X.,et al."Caffeic acid phenethyl ester prevents cerebellar granule neurons (CGNs) against glutamate-induced neurotoxicity".NEUROSCIENCE 155.4(2008):1098-1105.
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