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学科主题: 药物依赖
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Role of the NMDA receptor in cognitive deficits, anxiety and depressive-like behavior in juvenile and adult mice after neonatal dexamethasone exposure
作者: Li, Su-Xia1,2; Fujita, Yuko1; Zhang, Ji-Chun1; Ren, Qian1; Ishima, Tamaki1; Wu, Jin1; Hashimoto, Kenji1
关键词: Dexamethasone ; Hydrocortisone ; NMDA receptor ; GluN2B subunit ; Cognition ; Anxiety ; Depression ; Neonatal ; Juvenile ; Adult
刊名: NEUROBIOLOGY OF DISEASE
发表日期: 2014-02-01
DOI: 10.1016/j.nbd.2013.09.004
卷: 62, 页:124-134
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: CHRONIC LUNG-DISEASE ; BIRTH-WEIGHT INFANTS ; PREPULSE INHIBITION DEFICITS ; FOLLOW-UP ; D-SERINE ; POSTNATAL CORTICOSTEROIDS ; PRETERM INFANTS ; RAT-BRAIN ; HYDROCORTISONE TREATMENT ; CONTROLLED TRIAL
英文摘要:

Postnatal dexamethasone (DEX) therapy has been used to treat or prevent chronic lung disease after premature births. However, there are many reports of long-term negative neurodevelopmental sequelae following this treatment. In contrast, hydrocortisone (HYD), which has fewer neurodevelopment adverse effects, is used as an alternative for DEX. In this study, we report that neonatal DEX exposure (days 1-3) caused alterations of amino acids affecting N-methyl-D-aspartate (NMDA) receptor neurotransmission in mouse brains. Neonatal DEX, but not HYD, exposure (days 1-3) significantly decreased the GluN2B subunit of NMDA receptor in the hippocampus at juvenile and adult stages. Mice treated with DEX showed cognitive deficits, as well as anxiety and depressive-like behavior at juvenile and adult stages. In contrast, mice treated with HYD (days 1-3) showed no behavioral abnormalities at these stages. In the DEX suppression test, plasma levels of corticosterone in mice exposed neonatally to DEX and HYD were significantly higher at juvenile, but not adult stages. Pretreatment with Ro 63-1908, an antagonist at GluN2B subunit, 30 min before each injection of DEX, prevented cognitive deficits, as well as anxiety and depressive-like behavior in juvenile and adult mice. Interestingly, subsequent repeated (days 29-33) administration of Ro 63-1908 or L701324, an antagonist of the glycine modulatory site on the NMDA receptor, significantly suppressed behavioral abnormalities in juvenile and adult mice after neonatal DEX exposure. These results indicate that neonatal DEX, but not HYD, exposure produced behavioral abnormalities in juvenile and adult mice by altering glutamatergic neurotransmission via the NMDA receptor. The NMDA receptor antagonists may prevent or treat these DEX-induced neonatal behavioral abnormalities in later life. (C) 2013 Elsevier Inc. All rights reserved.

语种: 英语
项目资助者: JSPS Invitation Fellowship Program for Research in Japan ; Japan Society for the Promotion of Science (JSPS) ; Ministry of Education, Culture, Sports, Science and Technology, Japan
WOS记录号: WOS:000330553600012
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52917
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Chiba Univ, Ctr Forens Mental Hlth, Div Clin Neurosci, Chiba 2608670, Japan
2.Peking Univ, Natl Inst Drug Dependence, Beijing 100871, Peoples R China

Recommended Citation:
Li, Su-Xia,Fujita, Yuko,Zhang, Ji-Chun,et al. Role of the NMDA receptor in cognitive deficits, anxiety and depressive-like behavior in juvenile and adult mice after neonatal dexamethasone exposure[J]. NEUROBIOLOGY OF DISEASE,2014,62:124-134.
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