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学科主题: 临床医学
题名:
Increased expression of latent TGF-beta binding protein-1 and fibrillin-1 in human uterine leiomyomata
作者: Zhao, Yangyu1; Wen, Yan1; Polan, Mary Lake1; Qiao, Jie1; Chen, Bertha H.1
关键词: E-2 ; FBN-1 ; leiomyomata ; LTGF-beta-1 ; myometrium ; 17 beta-estradioI
刊名: MOLECULAR HUMAN REPRODUCTION
发表日期: 2007-05-01
DOI: 10.1093/molehr/gam007
卷: 13, 期:5-6, 页:343-349
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Developmental Biology ; Obstetrics & Gynecology ; Reproductive Biology
研究领域[WOS]: Developmental Biology ; Obstetrics & Gynecology ; Reproductive Biology
关键词[WOS]: GROWTH-FACTOR-BETA ; SMOOTH-MUSCLE-CELLS ; EXTRACELLULAR-MATRIX ; REPRODUCTIVE HORMONES ; CONNECTIVE-TISSUE ; MESSENGER-RNA ; FIBROSIS ; WOMEN ; GENE ; MICROFIBRILS
英文摘要:

We compared latent TGF-6 binding protein-1 (LTBP-1) and fibrillin-1 (FBN-1) expression in leiomyomata and myometrium, correlated with leiomyomata size. We studied in vivo and in vitro effects of ovarian steroids using matched leiomyomata and myometrium samples from both phases of the menstrual cycle. Leiomyomata were divided into small (<= 2 cm), medium (3-5 cm) and large (>= 6 cm) groups. We validated LTBP-1 and FBN-1 expression using QPCR, western blot and immunohistochemistry. LTBP-1 and FBN-1 mRNA and protein expressions were higher in the medium-sized group compared with myometrium in the proliferative phase (P = 0.01; P = 0.01). FBN-1 mRNA expression was higher in the secretory phase (P = 0.01). LTBP-1 mRNA and protein expression was higher in the medium group compared with the small and large groups in the proliferative phase (P = 0.04; P = 0.04). No differences between groups were seen in FBN-1 expression in either phase. 17 beta-eestradiol (E-2) increased mRNA and protein expression of LTBP-1 and FBN-1 in cultured leiomyoma smooth muscle cells (LSMC) (P < 0.05). No change in FBN-1 and LTBP-1 expression was observed when cells were treated with E2 plus progesterone. Estrogen may be involved in LTBP-1 and FBN-1 expression in leiomyomata. Extracellular matrix metabolism may be different in medium-sized leiomyoma.

语种: 英语
WOS记录号: WOS:000247348500007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52922
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Stanford Univ, Sch Med, Dept Obstet & Gynecol, Stanford, CA 94305 USA
2.Peking Univ, Dept Gynecol & Obstet, Third Hosp, Beijing 100871, Peoples R China

Recommended Citation:
Zhao, Yangyu,Wen, Yan,Polan, Mary Lake,et al. Increased expression of latent TGF-beta binding protein-1 and fibrillin-1 in human uterine leiomyomata[J]. MOLECULAR HUMAN REPRODUCTION,2007,13(5-6):343-349.
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