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学科主题: 药学
题名:
Microwave-assisted efficient synthesis of glucose-based 3-acetyl-5-alkyl-2,3-dihydro-1,3,4-oxadiazole derivatives catalyzed by sodium acetate
作者: Wang, Lin-Na; Han, Dong; Xu, Fei-Fei; Meng, Xiang-Bao; Li, Zhong-Jun
关键词: Carbohydrate ; 1,3,4-Oxadiazole derivatives ; Antitumor activity ; Microwave irradiation ; Cyclization
刊名: CARBOHYDRATE RESEARCH
发表日期: 2009-11-02
DOI: 10.1016/j.carres.2009.07.009
卷: 344, 期:16, 页:2113-2119
收录类别: SCI ; IC ; CCR
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Chemistry, Applied ; Chemistry, Organic
研究领域[WOS]: Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]: NMR ANALYSIS ; ACID ; 1,3,4-OXADIAZOLES ; HETEROCYCLES ; ELUCIDATION
英文摘要:

A novel approach to synthesize glucose-based 3-acetyl-5-alkyl-2,3-dihydro-1,3,4-oxadiazoles with the assistance of microwave irradiation was developed. The effects of different catalysts on the heterocyclization process were investigated, and the reaction conditions were optimized, with NaOAc emerging as the catalyst of choice. Under the optimized conditions, a series of novel 3-acetyl-5-alkyl-2,3-dihydro-1,3,4-oxadiazole derivatives 4 and 5 were successfully synthesized from hydrazones 2 and 3. The absolute configurations of hydrazones 2, 3 and oxadiazoles 4, 5 were confirmed by NMR spectroscopic data. The ratio of the isomers 4 and 5 was similar to 1:1. (C) 2009 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 20732001 ; 30672525
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000271254800001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52930
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China

Recommended Citation:
Wang, Lin-Na,Han, Dong,Xu, Fei-Fei,et al. Microwave-assisted efficient synthesis of glucose-based 3-acetyl-5-alkyl-2,3-dihydro-1,3,4-oxadiazole derivatives catalyzed by sodium acetate[J]. CARBOHYDRATE RESEARCH,2009,344(16):2113-2119.
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