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Amelioration of Dextran Sulphate Sodium-Induced Colitis in Mice by Echinacoside-Enriched Extract of Cistanche tubulosa
Jia, Yamin1,2; Guan, Qiunong2; Jiang, Yong3; Salh, Baljinder4; Guo, Yuhai1; Tu, Pengfei3; Du, Caigan2
关键词Colitis Inflammatory Bowel Disease Echinacoside Tgf-beta Herba Cistanche Tissue Repair
刊名PHYTOTHERAPY RESEARCH
2014
DOI10.1002/ptr.4967
28期:1页:110-119
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]INFLAMMATORY-BOWEL-DISEASE ; GROWTH-FACTOR ; IN-VIVO ; INTESTINAL INFLAMMATION ; PARKINSONS-DISEASE ; PHENOLIC-COMPOUNDS ; CELL APOPTOSIS ; KI-67 PROTEIN ; MURINE MODEL ; COLON-CANCER
英文摘要

Echinacoside (ECH) is a major bioactive phenyethanoids in medicinal herba Cistanche and has been reported to have antiinflammatory activity and beneficial effect on wound healing in many experimental studies. This study was to test the efficacy of ECH-enriched extract of Cistanche tubulosa in the treatment of dextran sulphate sodium (DSS)-induced colitis, a preclinical model of ulcerative colitis. Oral administration of ECH extract significantly suppresses the development of acute colitis, indicated by lowering disease activity index (p<0.0001, n=8) and preventing colonic damage (p=0.0336). Histological examinations showed that ECH extract treatment protected intestinal epithelium from inflammatory injury (p=0.0249) but had less effect on inflammatory cellular infiltration (p=0.1753). The beneficial effect of ECH extract treatment was associated with upregulation of transforming growth factor (TGF)-1 as well as with an increase in the number of Ki67(+) proliferating cells in diseased colons (p<0.0001). In cultured MODE-K cells, the addition of ECH extract enhanced in vitro wound healing that depended on TGF-1 expression. These data suggest that ECH extract possesses a greater efficacy in preventing DSS-induced colitis in mice, implying the potential of ECH or its derivatives for clinically treating inflammatory bowel disease. Copyright (c) 2013 John Wiley & Sons, Ltd.

语种英语
WOS记录号WOS:000329510400015
资助机构China Scholarship Council
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52942
专题北京大学药学院
北京大学药学院_天然药物学系
作者单位1.China Agr Univ, Coll Agr & Biotechnol, Beijing 100094, Peoples R China
2.Vancouver Coastal Hlth Res Inst, Immun & Infect Res Ctr, Vancouver, BC, Canada
3.Peking Univ, Sch Pharmaceut Sci, Modern Res Ctr Tradit Chinese Med, Beijing 100871, Peoples R China
4.Univ British Columbia, Dept Med, Div Gastroenterol, Vancouver, BC, Canada
推荐引用方式
GB/T 7714
Jia, Yamin,Guan, Qiunong,Jiang, Yong,et al. Amelioration of Dextran Sulphate Sodium-Induced Colitis in Mice by Echinacoside-Enriched Extract of Cistanche tubulosa[J]. PHYTOTHERAPY RESEARCH,2014,28(1):110-119.
APA Jia, Yamin.,Guan, Qiunong.,Jiang, Yong.,Salh, Baljinder.,Guo, Yuhai.,...&Du, Caigan.(2014).Amelioration of Dextran Sulphate Sodium-Induced Colitis in Mice by Echinacoside-Enriched Extract of Cistanche tubulosa.PHYTOTHERAPY RESEARCH,28(1),110-119.
MLA Jia, Yamin,et al."Amelioration of Dextran Sulphate Sodium-Induced Colitis in Mice by Echinacoside-Enriched Extract of Cistanche tubulosa".PHYTOTHERAPY RESEARCH 28.1(2014):110-119.
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