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学科主题: 药学
题名:
Amelioration of Dextran Sulphate Sodium-Induced Colitis in Mice by Echinacoside-Enriched Extract of Cistanche tubulosa
作者: Jia, Yamin1,2; Guan, Qiunong2; Jiang, Yong3; Salh, Baljinder4; Guo, Yuhai1; Tu, Pengfei3; Du, Caigan2
关键词: colitis ; inflammatory bowel disease ; echinacoside ; TGF-beta ; herba Cistanche ; tissue repair
刊名: PHYTOTHERAPY RESEARCH
发表日期: 2014
DOI: 10.1002/ptr.4967
卷: 28, 期:1, 页:110-119
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: INFLAMMATORY-BOWEL-DISEASE ; GROWTH-FACTOR ; IN-VIVO ; INTESTINAL INFLAMMATION ; PARKINSONS-DISEASE ; PHENOLIC-COMPOUNDS ; CELL APOPTOSIS ; KI-67 PROTEIN ; MURINE MODEL ; COLON-CANCER
英文摘要:

Echinacoside (ECH) is a major bioactive phenyethanoids in medicinal herba Cistanche and has been reported to have antiinflammatory activity and beneficial effect on wound healing in many experimental studies. This study was to test the efficacy of ECH-enriched extract of Cistanche tubulosa in the treatment of dextran sulphate sodium (DSS)-induced colitis, a preclinical model of ulcerative colitis. Oral administration of ECH extract significantly suppresses the development of acute colitis, indicated by lowering disease activity index (p<0.0001, n=8) and preventing colonic damage (p=0.0336). Histological examinations showed that ECH extract treatment protected intestinal epithelium from inflammatory injury (p=0.0249) but had less effect on inflammatory cellular infiltration (p=0.1753). The beneficial effect of ECH extract treatment was associated with upregulation of transforming growth factor (TGF)-1 as well as with an increase in the number of Ki67(+) proliferating cells in diseased colons (p<0.0001). In cultured MODE-K cells, the addition of ECH extract enhanced in vitro wound healing that depended on TGF-1 expression. These data suggest that ECH extract possesses a greater efficacy in preventing DSS-induced colitis in mice, implying the potential of ECH or its derivatives for clinically treating inflammatory bowel disease. Copyright (c) 2013 John Wiley & Sons, Ltd.

语种: 英语
项目资助者: China Scholarship Council
WOS记录号: WOS:000329510400015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52942
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.China Agr Univ, Coll Agr & Biotechnol, Beijing 100094, Peoples R China
2.Vancouver Coastal Hlth Res Inst, Immun & Infect Res Ctr, Vancouver, BC, Canada
3.Peking Univ, Sch Pharmaceut Sci, Modern Res Ctr Tradit Chinese Med, Beijing 100871, Peoples R China
4.Univ British Columbia, Dept Med, Div Gastroenterol, Vancouver, BC, Canada

Recommended Citation:
Jia, Yamin,Guan, Qiunong,Jiang, Yong,et al. Amelioration of Dextran Sulphate Sodium-Induced Colitis in Mice by Echinacoside-Enriched Extract of Cistanche tubulosa[J]. PHYTOTHERAPY RESEARCH,2014,28(1):110-119.
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