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A-Type Proanthocyanidins from the Stems of Ephedra sinica (Ephedraceae) and Their Antimicrobial Activities
Zang, Xinyu1; Shang, Mingying1; Xu, Feng1; Liang, Jing1; Wang, Xuan1; Mikage, Masayuki2; Cai, Shaoqing1
关键词Ephedra Sinica Ephedraceae A-type Proanthocyanidin Ephedrannin D-1 Ephedrannin Tr-1 Ephedrannin Te-1 Antimicrobial Activities
刊名MOLECULES
2013-05-01
DOI10.3390/molecules18055172
18期:5页:5172-5189
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]TANNINS ; ROOTS ; POLYPHENOLS ; DIMERS ; BARK
英文摘要

Phytochemical investigation of the n-BuOH-soluble fraction of the EtOH extract of the herbaceous stems of Ephedra sinica, which is known as Ephedrae Herba in Traditional Chinese Medicine, led to the isolation and identification of 12 A-type proanthocyanidins, containing five dimers, two trimers and five tetramers [i.e., (+)-epigallocatechin-(2 alpha -> O -> 7,4 alpha -> 8)-(-)-catechin, named ephedrannin D-1, a dimer; epigallocatechin-(2 alpha -> O -> 7,4 alpha -> 8)-epigallocatechin-(4 alpha -> 8)-catechin (ephedrannin Tr-1), a trimer; and epigallocatechin-(2 alpha -> O -> 7,4 alpha -> 8)-epigallocatechin-(4 alpha -> 8)- epigallocatechin-(2 alpha -> O -> 7,4 alpha -> 8)-gallocatechin, named ephedrannin Te-1, a tetramer). Tetramers composed of gallocatechin are reported for the first time in Ephedraceae. Catechin, epicatechin, gallocatechin, epigallocatechin and four known dimers were also isolated. The structures were elucidated by extensive spectroscopic analysis. The absolute configurations of the 4 alpha linkages, which were confirmed by NOESY and CD experiments, are the outstanding characteristic of most of these isolated A-type proanthocyanidins. The antimicrobial activities of these compounds were tested by measuring the minimum inhibitory concentrations (MIC) against bacteria (both Gram positive and Gram negative) and fungi, and were found to be in the range of 0.00515-1.38 mM. Compounds 6, 8, 10 and 11 exhibited moderate antimicrobial activities against Canidia albicans.

语种英语
WOS记录号WOS:000319446900023
项目编号30425018
资助机构National Outstanding Youth Funds of China
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52943
专题北京大学药学院
北京大学药学院_化学生物学系
北京大学药学院_天然药物学系
作者单位1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Kanazawa Univ, Grad Sch Nat Sci & Technol, Kanazawa, Ishikawa 4411212, Japan
推荐引用方式
GB/T 7714
Zang, Xinyu,Shang, Mingying,Xu, Feng,et al. A-Type Proanthocyanidins from the Stems of Ephedra sinica (Ephedraceae) and Their Antimicrobial Activities[J]. MOLECULES,2013,18(5):5172-5189.
APA Zang, Xinyu.,Shang, Mingying.,Xu, Feng.,Liang, Jing.,Wang, Xuan.,...&Cai, Shaoqing.(2013).A-Type Proanthocyanidins from the Stems of Ephedra sinica (Ephedraceae) and Their Antimicrobial Activities.MOLECULES,18(5),5172-5189.
MLA Zang, Xinyu,et al."A-Type Proanthocyanidins from the Stems of Ephedra sinica (Ephedraceae) and Their Antimicrobial Activities".MOLECULES 18.5(2013):5172-5189.
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