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学科主题: 药学
题名:
A-Type Proanthocyanidins from the Stems of Ephedra sinica (Ephedraceae) and Their Antimicrobial Activities
作者: Zang, Xinyu1; Shang, Mingying1; Xu, Feng1; Liang, Jing1; Wang, Xuan1; Mikage, Masayuki2; Cai, Shaoqing1
关键词: Ephedra sinica ; Ephedraceae ; A-type proanthocyanidin ; ephedrannin D-1 ; ephedrannin Tr-1 ; ephedrannin Te-1 ; antimicrobial activities
刊名: MOLECULES
发表日期: 2013-05-01
DOI: 10.3390/molecules18055172
卷: 18, 期:5, 页:5172-5189
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: TANNINS ; ROOTS ; POLYPHENOLS ; DIMERS ; BARK
英文摘要:

Phytochemical investigation of the n-BuOH-soluble fraction of the EtOH extract of the herbaceous stems of Ephedra sinica, which is known as Ephedrae Herba in Traditional Chinese Medicine, led to the isolation and identification of 12 A-type proanthocyanidins, containing five dimers, two trimers and five tetramers [i.e., (+)-epigallocatechin-(2 alpha -> O -> 7,4 alpha -> 8)-(-)-catechin, named ephedrannin D-1, a dimer; epigallocatechin-(2 alpha -> O -> 7,4 alpha -> 8)-epigallocatechin-(4 alpha -> 8)-catechin (ephedrannin Tr-1), a trimer; and epigallocatechin-(2 alpha -> O -> 7,4 alpha -> 8)-epigallocatechin-(4 alpha -> 8)- epigallocatechin-(2 alpha -> O -> 7,4 alpha -> 8)-gallocatechin, named ephedrannin Te-1, a tetramer). Tetramers composed of gallocatechin are reported for the first time in Ephedraceae. Catechin, epicatechin, gallocatechin, epigallocatechin and four known dimers were also isolated. The structures were elucidated by extensive spectroscopic analysis. The absolute configurations of the 4 alpha linkages, which were confirmed by NOESY and CD experiments, are the outstanding characteristic of most of these isolated A-type proanthocyanidins. The antimicrobial activities of these compounds were tested by measuring the minimum inhibitory concentrations (MIC) against bacteria (both Gram positive and Gram negative) and fungi, and were found to be in the range of 0.00515-1.38 mM. Compounds 6, 8, 10 and 11 exhibited moderate antimicrobial activities against Canidia albicans.

语种: 英语
所属项目编号: 30425018
项目资助者: National Outstanding Youth Funds of China
WOS记录号: WOS:000319446900023
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52943
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Kanazawa Univ, Grad Sch Nat Sci & Technol, Kanazawa, Ishikawa 4411212, Japan

Recommended Citation:
Zang, Xinyu,Shang, Mingying,Xu, Feng,et al. A-Type Proanthocyanidins from the Stems of Ephedra sinica (Ephedraceae) and Their Antimicrobial Activities[J]. MOLECULES,2013,18(5):5172-5189.
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