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Prognostic value of microsatellite instability in sporadic locally advanced rectal cancer following neoadjuvant radiotherapy
Du, Changzheng1; Zhao, Jun1; Xue, Weicheng2; Dou, Fangyuan2; Gu, Jin1
关键词Microsatellite Instability Neoadjuvant Radiotherapy Prognosis Rectal Cancer Tumour Response
刊名HISTOPATHOLOGY
2013-04-01
DOI10.1111/his.12069
62期:5页:723-730
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Pathology
研究领域[WOS]Cell Biology ; Pathology
关键词[WOS]TOTAL MESORECTAL EXCISION ; MISMATCH REPAIR PROTEIN ; COLORECTAL-CANCER ; ADJUVANT CHEMOTHERAPY ; COLON-CANCER ; IONIZING-RADIATION ; CHEMORADIATION ; EFFICACY ; OUTCOMES ; PREDICT
英文摘要

Aims This study was conducted to investigate the clinicopathological significance and prognostic value of microsatellite instability (MSI) in locally advanced rectal cancer (LARC) following neoadjuvant radiotherapy. Methods and results A total of 316 consecutive patients with LARC who underwent neoadjuvant radiotherapy and curative surgery were included retrospectively. Microsatellite instability in pretreatment biopsy tissue was assessed using the pentaplex panel of mononucleotides. Twenty-five tumours (7.9%) were assessed as high-frequency MSI (MSI-H) and 291 were low-frequency MSI (MSI-L; n=42) or microsatellite stable (MSS; n=249). There were no significant differences in terms of gender, age, tumour location or pretreatment serum carcinoembryonic antigen between the MSI-H and MSI-L+MSS groups. Microsatellite instability was not associated statistically with pathological stage, radiation-induced tumour regression or downstaging. No significant difference was found in disease-free survival (DFS) between the two groups but, within the subgroup of ypN0 stage, patients with MSI-H tumours presented a significantly improved DFS compared with those with MSI-L or MSS tumours (100% versus 79.8%, P<0.05), whereas no DFS improvement was observed for patients with MSI-H tumours in the ypN+subgroup. Conclusions Microsatellite instability could not predict a histopathological response to neoadjuvant radiotherapy, but was a good prognostic marker for patients without lymph node metastasis after neoadjuvant radiotherapy.

语种英语
WOS记录号WOS:000316911400006
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被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52948
专题北京大学临床肿瘤学院_胃肠肿瘤中心
北京大学临床肿瘤学院_病理科
北京大学临床肿瘤学院_结直肠肿瘤外科
作者单位1.Peking Univ Canc Hosp, Dept Pathol, Beijing 100142, Peoples R China
2.Peking Univ Canc Hosp, Dept Colorectal Surg, Beijing 100142, Peoples R China
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Du, Changzheng,Zhao, Jun,Xue, Weicheng,et al. Prognostic value of microsatellite instability in sporadic locally advanced rectal cancer following neoadjuvant radiotherapy[J]. HISTOPATHOLOGY,2013,62(5):723-730.
APA Du, Changzheng,Zhao, Jun,Xue, Weicheng,Dou, Fangyuan,&Gu, Jin.(2013).Prognostic value of microsatellite instability in sporadic locally advanced rectal cancer following neoadjuvant radiotherapy.HISTOPATHOLOGY,62(5),723-730.
MLA Du, Changzheng,et al."Prognostic value of microsatellite instability in sporadic locally advanced rectal cancer following neoadjuvant radiotherapy".HISTOPATHOLOGY 62.5(2013):723-730.
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