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学科主题: 临床医学
题名:
First Definition of Reference Intervals of Liver Function Tests in China: A Large-Population-Based Multi-Center Study about Healthy Adults
作者: Mu, Runqing1; Chen, Wenxiang2; Pan, Baishen3; Wang, Lanlan4; Hao, Xiaoke5; Huang, Xianzhang6; Qiao, Rui7; Zhao, Min1; Zhang, Chuanbao2; Guo, Wei3; Huang, Hengjian4; Ma, Yueyun5; Zhuang, Junhua6; Zhang, Jie7; Shang, Hong1
刊名: PLOS ONE
发表日期: 2013-09-13
DOI: 10.1371/journal.pone.0072916
卷: 8, 期:9
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: GAMMA-GLUTAMYL-TRANSFERASE ; COMMON REFERENCE INTERVALS ; METABOLIC SYNDROME ; SERUM ANALYTES ; RISK-FACTORS ; DISEASE ; AMINOTRANSFERASE ; AGE ; ALBUMIN
英文摘要:

Background: Reference intervals of Liver function tests are very important for the screening, diagnosis, treatment, and monitoring of liver diseases. We aim to establish common reference intervals of liver function tests specifically for the Chinese adult population.

Methods: A total of 3210 individuals (20-79 years) were enrolled in six representative geographical regions in China. Analytes of ALT, AST, GGT, ALP, total protein, albumin and total bilirubin were measured using three analytical systems mainly used in China. The newly established reference intervals were based on the results of traceability or multiple systems, and then validated in 21 large hospitals located nationwide qualified by the National External Quality Assessment (EQA) of China.

Results: We had been established reference intervals of the seven liver function tests for the Chinese adult population and found there were apparent variances of reference values for the variables for partitioning analysis such as gender(ALT, GGT, total bilirubin), age(ALP, albumin) and region(total protein). More than 86% of the 21 laboratories passed the validation in all subgroup of reference intervals and overall about 95.3% to 98.8% of the 1220 validation results fell within the range of the new reference interval for all liver function tests. In comparison with the currently recommended reference intervals in China, the single side observed proportions of out of range of reference values from our study for most of the tests deviated significantly from the nominal 2.5% such as total bilirubin (15.2%), ALP (0.2%), albumin (0.0%). Most of reference intervals in our study were obviously different from that of other races.

Conclusion: These used reference intervals are no longer applicable for the current Chinese population. We have established common reference intervals of liver function tests that are defined specifically for Chinese population and can be universally used among EQA-approved laboratories located all over China.

语种: 英语
所属项目编号: 2012BAI37B01
项目资助者: Ministry of Science and Technology of the People&prime ; s Republic of China
WOS记录号: WOS:000324408400009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52950
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Beijing Hosp, Natl Ctr Clin Labs, Beijing, Peoples R China
2.China Med Univ, Dept Lab Med, Hosp 1, Shenyang, Peoples R China
3.Fudan Univ, Dept Lab Med, Zhongshan Hosp, Shanghai 200433, Peoples R China
4.Sichuan Univ, Dept Lab Med, West China Hosp, Chengdu, Sichuan, Peoples R China
5.Fourth Mil Med Univ, Dept Lab Med, Xijing Hosp, Xian 710032, Shaanxi, Peoples R China
6.Guangzhou Univ Chinese Med, Affiliated Hosp 2, Dept Lab Sci, Guangzhou, Guangdong, Peoples R China
7.Peking Univ, Dept Lab Med, Hosp 3, Beijing 100871, Peoples R China

Recommended Citation:
Mu, Runqing,Chen, Wenxiang,Pan, Baishen,et al. First Definition of Reference Intervals of Liver Function Tests in China: A Large-Population-Based Multi-Center Study about Healthy Adults[J]. PLOS ONE,2013,8(9).
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