北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学临床肿瘤学院  > 期刊论文
学科主题: 临床医学
题名:
Identification and expression analysis of novel LAGE-1 alleles with single nucleotide polymorphisms in cancer patients
作者: Shao, Yi1,2,3; Sun, Zhen-yuan1,2,3; Sun, Shi-wei4; Zhao, Yi4; Sin, Wan Yee5; Yuan, Yan-hua3; Simpson, Andrew J.6; Old, Lloyd J.6; Sang, Xin-ting1,2; Mao, Yi-lei1,2; Xie, Yong5; Huang, Jie-fu1,2; Zhao, Hai-tao1,2
关键词: single nucleotide polymorphism ; LAGE-1 gene ; allele ; transcript variant ; cancer
刊名: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
发表日期: 2008-04-01
DOI: 10.1007/s00432-007-0312-z
卷: 134, 期:4, 页:495-502
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: T-CELL RESPONSES ; HUMAN TUMOR-ANTIGENS ; HEPATOCELLULAR-CARCINOMA ; ANTIBODY-RESPONSES ; IMMUNE-RESPONSE ; LUNG-CANCER ; NY-ESO-1 ; PEPTIDE ; GENE ; LYMPHOCYTES
英文摘要:

Objective The purpose of this study is to identify single nucleotide polymorphisms (SNPs) in the coding region alleles of the X chromosomal LAGE-1 gene, and investigate the frequency of such SNPs in both cancer patients and healthy controls, and thus determine the potential significance of these SNPs with respect to cancer vaccine therapy.

Methods In this study, different mRNAs transcribed from the LAGE-1 gene were identified by RT-PCR from healthy donors and cancer patients samples.

Results A new LAGE-1 allele containing three coding region SNPs (69A/G, 317C/G, and 397T/G) were identified. The allele is highly expressed as the LAGE-1a mRNA variant AY679089 in some of the cancer patients. The three SNPs altered the LAGE-1 gene sequence to that of NYESO-1 at both the nucleotide and amino acid level.

Conclusion There is a high frequency of the LAGE-1 gene allele with SNPs in coding regions in cancer patients. There was a clear relationship between the variant AY679089 and gastric cancer. The SNPs may lead to accelerated progress of poorly differentiated gastric cancer. The SNPs found in these alleles may also alter the immunological characteristics of LAGE-1a and should be taken into account if this antigen is adopted as a cancer vaccine component.

语种: 英语
WOS记录号: WOS:000253572000009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52952
Appears in Collections:北京大学临床肿瘤学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Liver Surg, Beijing 100730, Peoples R China
2.PUMC, Beijing 100730, Peoples R China
3.Peking Univ, Sch Oncol, Beijing Canc Hosp, Canc Immunol Therapy & Diagnosis Ctr, Beijing 100871, Peoples R China
4.Chinese Acad Sci, Inst Comp Technol, Bioinformat Lab, Beijing, Peoples R China
5.Hong Kong Univ Sci & Technol, Dept Biol, Kowloon, Hong Kong, Peoples R China
6.Ludwig Inst Canc Res, Mem Sloan Kettering Canc Ctr, New York Branch, New York, NY USA

Recommended Citation:
Shao, Yi,Sun, Zhen-yuan,Sun, Shi-wei,et al. Identification and expression analysis of novel LAGE-1 alleles with single nucleotide polymorphisms in cancer patients[J]. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY,2008,134(4):495-502.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Shao, Yi]'s Articles
[Sun, Zhen-yuan]'s Articles
[Sun, Shi-wei]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Shao, Yi]‘s Articles
[Sun, Zhen-yuan]‘s Articles
[Sun, Shi-wei]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace