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Recent advances in biomarkers for Parkinson′s disease focusing on biochemicals, omics and neuroimaging
Ren, Rutong1,2; Sun, Yi1,2; Zhao, Xin1,2; Pu, Xiaoping1,2
关键词Biomarker Neuroimaging Omics Parkinson&Prime s Disease Pathogenesis
刊名CLINICAL CHEMISTRY AND LABORATORY MEDICINE
2015-09-01
DOI10.1515/cclm-2014-0783
53期:10页:1495-1506
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Medical Laboratory Technology
资助者Science and Technology Major Projects: Significant New-Drugs Creation ; National Special Equipment Development Program ; Science and Technology Major Projects: Significant New-Drugs Creation ; National Special Equipment Development Program
研究领域[WOS]Medical Laboratory Technology
关键词[WOS]PHOSPHORYLATED ALPHA-SYNUCLEIN ; MULTIPLE SYSTEM ATROPHY ; CEREBROSPINAL-FLUID ; PROTEOMIC ANALYSIS ; OXIDIZED DJ-1 ; BLOOD-PLASMA ; URIC-ACID ; IN-VIVO ; DIAGNOSIS ; SERUM
英文摘要

Parkinson′s disease (PD) is one of the most common neurodegenerative disorders, involving progressive loss of the nigro-striatal dopaminergic neurons. Cardinal symptoms including tremors, muscle rigidity, drooping posture, drooping, walking difficulty, and autonomic symptoms appear when a significant number of nigrostriatal dopaminergic neurons have already been destroyed. Hence, reliable biomarkers are needed for early and accurate diagnosis to measure disease progression and response to therapy. We review the current status of protein and small molecule biomarkers involved in oxidative stress, protein aggregation and inflammation etc. which are present in cerebrospinal fluid, human blood, urine or saliva. In recent years, advances in genomics, proteomics, metabolomics, and functional brain imaging techniques have led to new insights into the pathoetiology of PD. Further studies in the novel discovery of PD biomarkers will provide avenues to treat PD patients more effectively with few or no side effects.

语种英语
所属项目编号2012ZX09103201-042 ; 2013YQ030651
资助者Science and Technology Major Projects: Significant New-Drugs Creation ; National Special Equipment Development Program ; Science and Technology Major Projects: Significant New-Drugs Creation ; National Special Equipment Development Program
WOS记录号WOS:000360851500014
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52958
专题北京大学药学院
作者单位1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Mol & Cellular Pharmacol, Beijing 100191, Peoples R China
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GB/T 7714
Ren, Rutong,Sun, Yi,Zhao, Xin,et al. Recent advances in biomarkers for Parkinson′s disease focusing on biochemicals, omics and neuroimaging[J]. CLINICAL CHEMISTRY AND LABORATORY MEDICINE,2015,53(10):1495-1506.
APA Ren, Rutong,Sun, Yi,Zhao, Xin,&Pu, Xiaoping.(2015).Recent advances in biomarkers for Parkinson′s disease focusing on biochemicals, omics and neuroimaging.CLINICAL CHEMISTRY AND LABORATORY MEDICINE,53(10),1495-1506.
MLA Ren, Rutong,et al."Recent advances in biomarkers for Parkinson′s disease focusing on biochemicals, omics and neuroimaging".CLINICAL CHEMISTRY AND LABORATORY MEDICINE 53.10(2015):1495-1506.
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