北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学药学院  > 期刊论文
学科主题: 药学
题名:
Recent advances in biomarkers for Parkinson′s disease focusing on biochemicals, omics and neuroimaging
作者: Ren, Rutong1,2; Sun, Yi1,2; Zhao, Xin1,2; Pu, Xiaoping1,2
关键词: biomarker ; neuroimaging ; omics ; Parkinson&prime ; s disease ; pathogenesis
刊名: CLINICAL CHEMISTRY AND LABORATORY MEDICINE
发表日期: 2015-09-01
DOI: 10.1515/cclm-2014-0783
卷: 53, 期:10, 页:1495-1506
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Medical Laboratory Technology
研究领域[WOS]: Medical Laboratory Technology
关键词[WOS]: PHOSPHORYLATED ALPHA-SYNUCLEIN ; MULTIPLE SYSTEM ATROPHY ; CEREBROSPINAL-FLUID ; PROTEOMIC ANALYSIS ; OXIDIZED DJ-1 ; BLOOD-PLASMA ; URIC-ACID ; IN-VIVO ; DIAGNOSIS ; SERUM
英文摘要:

Parkinson′s disease (PD) is one of the most common neurodegenerative disorders, involving progressive loss of the nigro-striatal dopaminergic neurons. Cardinal symptoms including tremors, muscle rigidity, drooping posture, drooping, walking difficulty, and autonomic symptoms appear when a significant number of nigrostriatal dopaminergic neurons have already been destroyed. Hence, reliable biomarkers are needed for early and accurate diagnosis to measure disease progression and response to therapy. We review the current status of protein and small molecule biomarkers involved in oxidative stress, protein aggregation and inflammation etc. which are present in cerebrospinal fluid, human blood, urine or saliva. In recent years, advances in genomics, proteomics, metabolomics, and functional brain imaging techniques have led to new insights into the pathoetiology of PD. Further studies in the novel discovery of PD biomarkers will provide avenues to treat PD patients more effectively with few or no side effects.

语种: 英语
所属项目编号: 2012ZX09103201-042 ; 2013YQ030651
项目资助者: Science and Technology Major Projects: Significant New-Drugs Creation ; National Special Equipment Development Program
WOS记录号: WOS:000360851500014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52958
Appears in Collections:北京大学药学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Mol & Cellular Pharmacol, Beijing 100191, Peoples R China

Recommended Citation:
Ren, Rutong,Sun, Yi,Zhao, Xin,et al. Recent advances in biomarkers for Parkinson′s disease focusing on biochemicals, omics and neuroimaging[J]. CLINICAL CHEMISTRY AND LABORATORY MEDICINE,2015,53(10):1495-1506.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Ren, Rutong]'s Articles
[Sun, Yi]'s Articles
[Zhao, Xin]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Ren, Rutong]‘s Articles
[Sun, Yi]‘s Articles
[Zhao, Xin]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace