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学科主题: 临床医学
题名:
Activation of endoplasmic reticulum stress in degenerating photoreceptors of the rd1 mouse
作者: Yang, Li-ping1; Wu, Le-meng1; Guo, Xiu-juan1; Tso, Mark O. M.1
刊名: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
发表日期: 2007-11-01
DOI: 10.1167/iovs.07-0512
卷: 48, 期:11, 页:5191-5198
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Ophthalmology
研究领域[WOS]: Ophthalmology
关键词[WOS]: UNFOLDED PROTEIN RESPONSE ; RECESSIVE RETINITIS-PIGMENTOSA ; NEURONAL CELL-DEATH ; RETINAL DEGENERATION ; ER STRESS ; BETA-SUBUNIT ; ROD PHOSPHODIESTERASE ; CASPASE-12 ; APOPTOSIS ; CALCIUM
英文摘要:

PURPOSE. Endoplasmic reticulum ( ER) stress has been implicated in a wide variety of neurodegenerative disorders of the central nervous system ( CNS). This study was designed to elucidate the role of ER stress in photoreceptor apoptosis in the rd1 mouse.

METHODS. Photoreceptor apoptosis in the rd1 mouse was detected by terminal dUTP transferase nick- end labeling ( TUNEL). Protein expressions of ER stress sensors, including glucose- regulated protein- 78 ( GRP78/ BiP), caspase- 12, phospho-eukaryotic initiation factor 2 alpha (eIF2 alpha), and phospho- pancreatic ER kinase ( PERK), were examined by immunofluorescence and Western blot assays.

RESULTS. Accompanying photoreceptor apoptosis in the rd1 mouse, the protein expressions of GRP78/ BiP, caspase- 12, phospho-eIF2 alpha, and phospho- PERK were upregulated in a time- dependent manner. The upregulation of these proteins coincided with or preceded photoreceptor apoptosis. At the peak of their expression, these proteins were primarily located in the photoreceptor inner segments, the outer nuclear layer, or both.

CONCLUSIONS. ER stress plays an important role in photoreceptor apoptosis in the rd1 mouse. Therefore, ER stress modulators may be strong candidates as therapeutic agents in the treatment of retinal degenerative diseases.

语种: 英语
WOS记录号: WOS:000250734800044
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52960
Appears in Collections:北京大学第三临床医学院_眼科_期刊论文

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作者单位: 1.Peking Univ, Peking Univ Eye Ctr, Peking Univ Hosp 3, Beijing 100083, Peoples R China
2.Johns Hopkins Univ, Sch Med, Wilmer Eye Inst, Baltimore, MD 21205 USA

Recommended Citation:
Yang, Li-ping,Wu, Le-meng,Guo, Xiu-juan,et al. Activation of endoplasmic reticulum stress in degenerating photoreceptors of the rd1 mouse[J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE,2007,48(11):5191-5198.
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