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学科主题临床医学
Activation of endoplasmic reticulum stress in degenerating photoreceptors of the rd1 mouse
Yang, Li-ping1; Wu, Le-meng1; Guo, Xiu-juan1; Tso, Mark O. M.1
刊名INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
2007-11-01
DOI10.1167/iovs.07-0512
48期:11页:5191-5198
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Ophthalmology
研究领域[WOS]Ophthalmology
关键词[WOS]UNFOLDED PROTEIN RESPONSE ; RECESSIVE RETINITIS-PIGMENTOSA ; NEURONAL CELL-DEATH ; RETINAL DEGENERATION ; ER STRESS ; BETA-SUBUNIT ; ROD PHOSPHODIESTERASE ; CASPASE-12 ; APOPTOSIS ; CALCIUM
英文摘要

PURPOSE. Endoplasmic reticulum ( ER) stress has been implicated in a wide variety of neurodegenerative disorders of the central nervous system ( CNS). This study was designed to elucidate the role of ER stress in photoreceptor apoptosis in the rd1 mouse.

METHODS. Photoreceptor apoptosis in the rd1 mouse was detected by terminal dUTP transferase nick- end labeling ( TUNEL). Protein expressions of ER stress sensors, including glucose- regulated protein- 78 ( GRP78/ BiP), caspase- 12, phospho-eukaryotic initiation factor 2 alpha (eIF2 alpha), and phospho- pancreatic ER kinase ( PERK), were examined by immunofluorescence and Western blot assays.

RESULTS. Accompanying photoreceptor apoptosis in the rd1 mouse, the protein expressions of GRP78/ BiP, caspase- 12, phospho-eIF2 alpha, and phospho- PERK were upregulated in a time- dependent manner. The upregulation of these proteins coincided with or preceded photoreceptor apoptosis. At the peak of their expression, these proteins were primarily located in the photoreceptor inner segments, the outer nuclear layer, or both.

CONCLUSIONS. ER stress plays an important role in photoreceptor apoptosis in the rd1 mouse. Therefore, ER stress modulators may be strong candidates as therapeutic agents in the treatment of retinal degenerative diseases.

语种英语
WOS记录号WOS:000250734800044
引用统计
被引频次:50[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52960
专题北京大学第三临床医学院_眼科
作者单位1.Peking Univ, Peking Univ Eye Ctr, Peking Univ Hosp 3, Beijing 100083, Peoples R China
2.Johns Hopkins Univ, Sch Med, Wilmer Eye Inst, Baltimore, MD 21205 USA
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Yang, Li-ping,Wu, Le-meng,Guo, Xiu-juan,et al. Activation of endoplasmic reticulum stress in degenerating photoreceptors of the rd1 mouse[J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE,2007,48(11):5191-5198.
APA Yang, Li-ping,Wu, Le-meng,Guo, Xiu-juan,&Tso, Mark O. M..(2007).Activation of endoplasmic reticulum stress in degenerating photoreceptors of the rd1 mouse.INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE,48(11),5191-5198.
MLA Yang, Li-ping,et al."Activation of endoplasmic reticulum stress in degenerating photoreceptors of the rd1 mouse".INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 48.11(2007):5191-5198.
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