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学科主题: 临床医学
题名:
Tissue Engineering Penoplasty With Biodegradable Scaffold Maxpol-T Cografted Autologous Fibroblasts for Small Penis Syndrome
作者: Jin, Zhe1; Wu, Yi-Guang2; Yuan, Yi-Ming1; Peng, Jing1; Gong, Yan-Qing1; Li, Guang-Yong1; Song, Wei-Dong1; Cui, Wan-Shou1; He, Xue-You2; Xin, Zhong-Cheng1
关键词: PLGA scaffold ; small penis ; autologous fibroblasts ; penoplasty
刊名: JOURNAL OF ANDROLOGY
发表日期: 2011-09-01
DOI: 10.2164/jandrol.110.011247
卷: 32, 期:5, 页:491-495
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Andrology
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: SIZE
英文摘要:

In this study, we investigated the safety and efficacy of a poly acid-co-glycolide biodegradable scaffold (Maxpol-T) coated by autologous fibroblasts (AF) for penile girth enlargement in small penis syndrome (SPS). Eighty patients with SPS were enrolled in a clinical study at 2 medical centers; 69 patients completed the study protocol. Scrotal skin was harvested under local anesthesia, and AFs were cultured and seeded on a Maxpol-T scaffold; the cografted scaffold was implanted under the Buck′s fascia of penile shaft via a circumcising incision. Patients were followed up at 1, 3, and 6 months to evaluate penile girth changes. Patient satisfaction was assessed via Visual Analogue Scale and scored on the International Index of Erectile Function-5 (IIEF-5). Mean preoperative penile girth in the flaccid and erect state was 8.18 +/- 0.83 cm and 10.26 +/- 1.22 cm, respectively. At the 6-month postoperative follow-up, mean penile girth in the flaccid and erect state was increased to 12.19 +/- 1.27 cm and 13.18 +/- 1.31 cm, respectively (P < .001 for change in both flaccid and erect state). Sixty-five patients (94.2%) reported satisfaction with the procedure. Among them, 4 cases (5.8%) were dissatisfied, 7 cases (10.1%) were satisfied, 26 cases (37.7%) were very satisfied, and 32 cases (46.4%) were extremely satisfied. All men maintained IIEF-5 scores of more than 22. Complications included prolonged subcutaneous edema in 3 patients (4.3%) and pinpoint erosion at the suture area in 3 patients (4.3%). Implantation of autologous fibroblasts seeded on a Maxpol-T collagen scaffold holds promise as a safe and novel technique for penile girth enhancement in patients with SPS.

语种: 英语
所属项目编号: Z08050703320000
项目资助者: Beijing Municipal Science and Technology Commission
WOS记录号: WOS:000293551300007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52961
Appears in Collections:北京大学第一临床医学院_男科中心_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Androl Ctr, Beijing 100009, Peoples R China
2.Chinese Peoples Liberat Army Gen Hosp, Dept Urol, Beijing, Peoples R China

Recommended Citation:
Jin, Zhe,Wu, Yi-Guang,Yuan, Yi-Ming,et al. Tissue Engineering Penoplasty With Biodegradable Scaffold Maxpol-T Cografted Autologous Fibroblasts for Small Penis Syndrome[J]. JOURNAL OF ANDROLOGY,2011,32(5):491-495.
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