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学科主题临床医学
Involvement of high mobility group box 1 in the activation of C5a-primed neutrophils induced by ANCA
Wang, Chen1; Wang, Huan1; Hao, Jian1; Chang, Dong-Yuan1; Zhao, Ming-Hui1; Chen, Min1
关键词Hmgb1 C5a Anca Neutrophils
刊名CLINICAL IMMUNOLOGY
2015-07-01
DOI10.1016/j.clim.2015.04.008
159期:1页:47-57
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
关键词[WOS]ANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODIES ; ALTERNATIVE COMPLEMENT PATHWAY ; ANTIBODY-ASSOCIATED VASCULITIS ; MOLECULAR-STRUCTURE ; CHROMATIN PROTEIN ; GLOMERULONEPHRITIS ; HMGB1 ; MYELOPEROXIDASE ; RELEASE ; MICE
英文摘要

C5a plays a central role in antineutrophil cytoplasmic antibody (ANCA)-mediated neutrophil recruitment and activation. A previous study showed that C5a played a crucial role in the regulation of high mobility group box 1 (HMGB1) release from human neutrophils. The current study further investigated the interaction between C5a and HMGB1 in ANCA-induced neutrophil activation. The effects of HMGB1 inhibitors on the translocation of ANCA antigens, ANCA-induced respiratory burst and degranulation of C5a-primed neutrophils were tested. We found that blocking HMGB1 decreased C5a-mediated translocation of ANCA antigens, as well as ANCA-induced respiratory burst and degranulation of C5a-primed neutrophils. Further study showed that supernatant of C5a-primed neutrophils, which contained HMGB1, also caused translocation of ANCA antigens of primary neutrophils, whereas blocking HMGB1 decreased the translocation. In conclusion, blocking HMGB1 may attenuate ANCA-induced activation of C5a-primed neutrophils. The interaction between HMGB1 and C5a might play an important role in ANCA-induced neutrophil activation. (C) 2015 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000356564600006
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被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52965
专题北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
2.Minist Hlth China, Key Lab Renal Dis, Beijing 100034, Peoples R China
3.Peking Univ, Div Renal, Dept Med, Hosp 1, Beijing 100034, Peoples R China
4.Peking Univ, China Peking Tsinghua Ctr Life Sci, Minist Educ, Key Lab Chron Kidney Dis Prevent & Treatment, Beijing 100034, Peoples R China
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Wang, Chen,Wang, Huan,Hao, Jian,et al. Involvement of high mobility group box 1 in the activation of C5a-primed neutrophils induced by ANCA[J]. CLINICAL IMMUNOLOGY,2015,159(1):47-57.
APA Wang, Chen,Wang, Huan,Hao, Jian,Chang, Dong-Yuan,Zhao, Ming-Hui,&Chen, Min.(2015).Involvement of high mobility group box 1 in the activation of C5a-primed neutrophils induced by ANCA.CLINICAL IMMUNOLOGY,159(1),47-57.
MLA Wang, Chen,et al."Involvement of high mobility group box 1 in the activation of C5a-primed neutrophils induced by ANCA".CLINICAL IMMUNOLOGY 159.1(2015):47-57.
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