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学科主题: 临床医学
题名:
Involvement of high mobility group box 1 in the activation of C5a-primed neutrophils induced by ANCA
作者: Wang, Chen1; Wang, Huan1; Hao, Jian1; Chang, Dong-Yuan1; Zhao, Ming-Hui1; Chen, Min1
关键词: HMGB1 ; C5a ; ANCA ; Neutrophils
刊名: CLINICAL IMMUNOLOGY
发表日期: 2015-07-01
DOI: 10.1016/j.clim.2015.04.008
卷: 159, 期:1, 页:47-57
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: ANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODIES ; ALTERNATIVE COMPLEMENT PATHWAY ; ANTIBODY-ASSOCIATED VASCULITIS ; MOLECULAR-STRUCTURE ; CHROMATIN PROTEIN ; GLOMERULONEPHRITIS ; HMGB1 ; MYELOPEROXIDASE ; RELEASE ; MICE
英文摘要:

C5a plays a central role in antineutrophil cytoplasmic antibody (ANCA)-mediated neutrophil recruitment and activation. A previous study showed that C5a played a crucial role in the regulation of high mobility group box 1 (HMGB1) release from human neutrophils. The current study further investigated the interaction between C5a and HMGB1 in ANCA-induced neutrophil activation. The effects of HMGB1 inhibitors on the translocation of ANCA antigens, ANCA-induced respiratory burst and degranulation of C5a-primed neutrophils were tested. We found that blocking HMGB1 decreased C5a-mediated translocation of ANCA antigens, as well as ANCA-induced respiratory burst and degranulation of C5a-primed neutrophils. Further study showed that supernatant of C5a-primed neutrophils, which contained HMGB1, also caused translocation of ANCA antigens of primary neutrophils, whereas blocking HMGB1 decreased the translocation. In conclusion, blocking HMGB1 may attenuate ANCA-induced activation of C5a-primed neutrophils. The interaction between HMGB1 and C5a might play an important role in ANCA-induced neutrophil activation. (C) 2015 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 2012CB517702 ; 81425008 ; 81321064 ; 81300599 ; 20120001110018 ; 2011BAI10B04
项目资助者: Chinese 973 project ; National Natural Science Fund ; Research Fund for the Doctoral Program of Higher Education of China ; "National Key Technology Research and Development (R&amp ; D) Program" of the Ministry of Science and Technology of China
WOS记录号: WOS:000356564600006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52965
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
2.Minist Hlth China, Key Lab Renal Dis, Beijing 100034, Peoples R China
3.Peking Univ, Div Renal, Dept Med, Hosp 1, Beijing 100034, Peoples R China
4.Peking Univ, China Peking Tsinghua Ctr Life Sci, Minist Educ, Key Lab Chron Kidney Dis Prevent & Treatment, Beijing 100034, Peoples R China

Recommended Citation:
Wang, Chen,Wang, Huan,Hao, Jian,et al. Involvement of high mobility group box 1 in the activation of C5a-primed neutrophils induced by ANCA[J]. CLINICAL IMMUNOLOGY,2015,159(1):47-57.
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