IR@PKUHSC  > 北京大学基础医学院  > 病理学系
学科主题基础医学
Pathophysiological significance of a reaction in mouse gastrointestinal tract associated with delayed-type hypersensitivity
Yu, Wan-Gui2; Lin, Ping3; Pan, Hui1; Xiao, Lan1; Gong, En-Cong4; Mei, Lin1
刊名WORLD JOURNAL OF GASTROENTEROLOGY
2004-08-01
10期:15页:2254-2258
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Gastroenterology & Hepatology
英文摘要

AIM: To explore the pathophysiological significance of delayed type hypersensitivity (DTH) reaction in mouse gastrointestinal tract induced by allergen 2,4-dinitrochlorbenzene(DNCB).

METHODS: BALB/c mice were randomly divided into control and DTH1-6 groups. After sensitized by DNCB smeared on the abdominal skin, the mice were challenged with DNCB by gavage or enema. The weight, stool viscosity and hematochezia were observed and accumulated as disease active index (DAI) score; the gastrointestinal motility was represented by active charcoal propulsion rate; the colon pathological score was achieved by macropathology and HE staining of section prepared for microscopy; and the leukocyte migration inhibitory factor (LMIF) activity was determined by indirect capillary assay of the absorbance (A) of migrated leukocytes.

RESULTS: Active charcoal propulsion rates of small intestine in the DNCB gavages groups were significantly higher than that in the control group (p < 0.01). The DAI scores and pathological score in DNCB enema groups were also higher than that in the control group (p < 0.05), and there were significant rises in LMIF activity in DNCB enema groups as compared with control groups (p < 0.01).

CONCLUSION: Mouse gastrointestinal DTH reaction could be induced by DNCB, which might facilitate the mechanism underlying the ulcerative colitis.

Yu WG, Lin P, Pan H, xiao L, Gong EC, Mei L. Pathophysiological significance of a reaction in mouse gastrointestinal tract associated with delayed-type hypersensitivity. World J Gastroenterol 2004; 10(15): 2254-2258 http://www.wjgnet.com/1007-9327/10/2254.asp

语种英语
所属项目编号30170419
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000208317500020
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52975
Collection北京大学基础医学院_病理学系
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100083, Peoples R China
2.Yangtze Univ, Med Coll, Dept Physiol, Jinzhou 434000, Hubei Province, Peoples R China
3.Hubei Inst Nationalities, Med Sch, Dept Physiol, Enshi 445000, Hubei Province, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Yu, Wan-Gui,Lin, Ping,Pan, Hui,et al. Pathophysiological significance of a reaction in mouse gastrointestinal tract associated with delayed-type hypersensitivity[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2004,10(15):2254-2258.
APA Yu, Wan-Gui,Lin, Ping,Pan, Hui,Xiao, Lan,Gong, En-Cong,&Mei, Lin.(2004).Pathophysiological significance of a reaction in mouse gastrointestinal tract associated with delayed-type hypersensitivity.WORLD JOURNAL OF GASTROENTEROLOGY,10(15),2254-2258.
MLA Yu, Wan-Gui,et al."Pathophysiological significance of a reaction in mouse gastrointestinal tract associated with delayed-type hypersensitivity".WORLD JOURNAL OF GASTROENTEROLOGY 10.15(2004):2254-2258.
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