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学科主题: 基础医学
题名:
Pathophysiological significance of a reaction in mouse gastrointestinal tract associated with delayed-type hypersensitivity
作者: Yu, Wan-Gui2; Lin, Ping3; Pan, Hui1; Xiao, Lan1; Gong, En-Cong4; Mei, Lin1
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2004-08-01
卷: 10, 期:15, 页:2254-2258
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
英文摘要:

AIM: To explore the pathophysiological significance of delayed type hypersensitivity (DTH) reaction in mouse gastrointestinal tract induced by allergen 2,4-dinitrochlorbenzene(DNCB).

METHODS: BALB/c mice were randomly divided into control and DTH1-6 groups. After sensitized by DNCB smeared on the abdominal skin, the mice were challenged with DNCB by gavage or enema. The weight, stool viscosity and hematochezia were observed and accumulated as disease active index (DAI) score; the gastrointestinal motility was represented by active charcoal propulsion rate; the colon pathological score was achieved by macropathology and HE staining of section prepared for microscopy; and the leukocyte migration inhibitory factor (LMIF) activity was determined by indirect capillary assay of the absorbance (A) of migrated leukocytes.

RESULTS: Active charcoal propulsion rates of small intestine in the DNCB gavages groups were significantly higher than that in the control group (p < 0.01). The DAI scores and pathological score in DNCB enema groups were also higher than that in the control group (p < 0.05), and there were significant rises in LMIF activity in DNCB enema groups as compared with control groups (p < 0.01).

CONCLUSION: Mouse gastrointestinal DTH reaction could be induced by DNCB, which might facilitate the mechanism underlying the ulcerative colitis.

Yu WG, Lin P, Pan H, xiao L, Gong EC, Mei L. Pathophysiological significance of a reaction in mouse gastrointestinal tract associated with delayed-type hypersensitivity. World J Gastroenterol 2004; 10(15): 2254-2258 http://www.wjgnet.com/1007-9327/10/2254.asp

语种: 英语
所属项目编号: 30170419
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000208317500020
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52975
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100083, Peoples R China
2.Yangtze Univ, Med Coll, Dept Physiol, Jinzhou 434000, Hubei Province, Peoples R China
3.Hubei Inst Nationalities, Med Sch, Dept Physiol, Enshi 445000, Hubei Province, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100083, Peoples R China

Recommended Citation:
Yu, Wan-Gui,Lin, Ping,Pan, Hui,et al. Pathophysiological significance of a reaction in mouse gastrointestinal tract associated with delayed-type hypersensitivity[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2004,10(15):2254-2258.
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