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学科主题基础医学
Serum Protein N-Glycans Profiling for the Discovery of Potential Biomarkers for Nonalcoholic Steatohepatitis
Chen, Cuiying1,2; Schmilovtz-Weiss, Hemda4,5; Liu, Xue-en1,2,3; Pappo, Orit6; Halpern, Marlsa1; Sulkes, Jaqueline1; Braun, Marius4,5; Cohen, Maya7,8; Barak, Nir4,5; Tur-Kaspa, Ran4,5; Vanhooren, Valerie1,2; Van Vlierberghe, Hans1; Libert, Claude1,2; Contreras, Roland1,2; Ben-Arl, Ziv4,5
关键词NASH NAFLD liver fibrosis noninvasive fatty liver N-glycan glycomics
刊名JOURNAL OF PROTEOME RESEARCH
2009-02-01
DOI10.1021/pr800656a
8期:2页:463-470
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemical Research Methods
资助者Ghent University ; Flanders-China Bilateral project ; Ghent University ; Flanders-China Bilateral project
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]FATTY LIVER-DISEASE ; HEPATOCELLULAR-CARCINOMA ; CORE FUCOSYLATION ; GLYCOMIC CHANGES ; CIRRHOSIS ; HEPATITIS ; DIAGNOSIS ; ACETYLGLUCOSAMINYLTRANSFERASE ; EXPRESSION ; ANTIBODY
英文摘要

The hepatic histology in nonalcoholic fatty liver disease can vary from isolated hepatic steatosis to steatohepatitis can progress to cirrhosis and liver-related death, The aim was to evaluate the use of blood serum N-glycan fingerprinting as a tool for differential diagnosis of nonalcoholic steatohepatitis from steatosis. A group of 47 patients with NAFLD was diagnosed by clinical laboratory analysis and ultrasonography, and was studied histologically using the Brunt′s scoring system. The control group included 13 healthy individuals. N-glycan profiles of serum proteins were determined by DNA sequencer-based carbohydrate analytical profiling. We have found that the concentrations of two glycans (NGA2F and NA2) and their logarithm ratio of NGA2F versus NA2 (named GlycoNashTest) were associated with the degree of NASH-related fibrosis, but had no correlation with the grade of inflammation nor steatosis severity. When used to screen NAFLD patients, GlycoNashTest could identify advanced NASH-related fibrosis (F3-F4) with the diagnosis sensitivity of 89.5% and specificity of 71.4%. The serum N-glycan profile is a promising noninvasive method for detecting NASH or NASH-related fibrosis in NAFLD patients, which could be a valuable supplement to other markers currently used in diagnosis of NASH.

语种英语
所属项目编号01106205 ; 011S605
资助者Ghent University ; Flanders-China Bilateral project ; Ghent University ; Flanders-China Bilateral project
WOS记录号WOS:000263193300007
引用统计
被引频次:27[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52982
专题基础医学院_病原生物学系
作者单位1.VIB, Dept Mol Biomed Res, Ghent, Belgium
2.Univ Ghent, Dept Mol Biol, B-9000 Ghent, Belgium
3.Beilinson Med Ctr, Liver Inst, Petah Tiqwa, Israel
4.Beilinson Med Ctr, Dept Med D, Petah Tiqwa, Israel
5.Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel
6.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100871, Peoples R China
7.Beilinson Med Ctr, Gastroenterol Unit, Rabin Med Ctr, Dept Histopathol, Petah Tiqwa, Israel
8.Beilinson Med Ctr, Epidemiol Unit, Dept Radiol, Rabin Med Ctr, Petah Tiqwa, Israel
9.Ghent Univ Hosp, Dept Gastroenterol & Hepatol, B-9000 Ghent, Belgium
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GB/T 7714
Chen, Cuiying,Schmilovtz-Weiss, Hemda,Liu, Xue-en,et al. Serum Protein N-Glycans Profiling for the Discovery of Potential Biomarkers for Nonalcoholic Steatohepatitis[J]. JOURNAL OF PROTEOME RESEARCH,2009,8(2):463-470.
APA Chen, Cuiying.,Schmilovtz-Weiss, Hemda.,Liu, Xue-en.,Pappo, Orit.,Halpern, Marlsa.,...&Ben-Arl, Ziv.(2009).Serum Protein N-Glycans Profiling for the Discovery of Potential Biomarkers for Nonalcoholic Steatohepatitis.JOURNAL OF PROTEOME RESEARCH,8(2),463-470.
MLA Chen, Cuiying,et al."Serum Protein N-Glycans Profiling for the Discovery of Potential Biomarkers for Nonalcoholic Steatohepatitis".JOURNAL OF PROTEOME RESEARCH 8.2(2009):463-470.
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