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学科主题: 基础医学
题名:
Serum Protein N-Glycans Profiling for the Discovery of Potential Biomarkers for Nonalcoholic Steatohepatitis
作者: Chen, Cuiying1,2; Schmilovtz-Weiss, Hemda4,5; Liu, Xue-en1,2,3; Pappo, Orit6; Halpern, Marlsa1; Sulkes, Jaqueline1; Braun, Marius4,5; Cohen, Maya7,8; Barak, Nir4,5; Tur-Kaspa, Ran4,5; Vanhooren, Valerie1,2; Van Vlierberghe, Hans1; Libert, Claude1,2; Contreras, Roland1,2; Ben-Arl, Ziv4,5
关键词: NASH ; NAFLD ; liver fibrosis ; noninvasive ; fatty liver ; N-glycan ; glycomics
刊名: JOURNAL OF PROTEOME RESEARCH
发表日期: 2009-02-01
DOI: 10.1021/pr800656a
卷: 8, 期:2, 页:463-470
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemical Research Methods
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: FATTY LIVER-DISEASE ; HEPATOCELLULAR-CARCINOMA ; CORE FUCOSYLATION ; GLYCOMIC CHANGES ; CIRRHOSIS ; HEPATITIS ; DIAGNOSIS ; ACETYLGLUCOSAMINYLTRANSFERASE ; EXPRESSION ; ANTIBODY
英文摘要:

The hepatic histology in nonalcoholic fatty liver disease can vary from isolated hepatic steatosis to steatohepatitis can progress to cirrhosis and liver-related death, The aim was to evaluate the use of blood serum N-glycan fingerprinting as a tool for differential diagnosis of nonalcoholic steatohepatitis from steatosis. A group of 47 patients with NAFLD was diagnosed by clinical laboratory analysis and ultrasonography, and was studied histologically using the Brunt′s scoring system. The control group included 13 healthy individuals. N-glycan profiles of serum proteins were determined by DNA sequencer-based carbohydrate analytical profiling. We have found that the concentrations of two glycans (NGA2F and NA2) and their logarithm ratio of NGA2F versus NA2 (named GlycoNashTest) were associated with the degree of NASH-related fibrosis, but had no correlation with the grade of inflammation nor steatosis severity. When used to screen NAFLD patients, GlycoNashTest could identify advanced NASH-related fibrosis (F3-F4) with the diagnosis sensitivity of 89.5% and specificity of 71.4%. The serum N-glycan profile is a promising noninvasive method for detecting NASH or NASH-related fibrosis in NAFLD patients, which could be a valuable supplement to other markers currently used in diagnosis of NASH.

语种: 英语
所属项目编号: 01106205 ; 011S605
项目资助者: Ghent University ; Flanders-China Bilateral project
WOS记录号: WOS:000263193300007
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52982
Appears in Collections:基础医学院_病原生物学系_期刊论文

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作者单位: 1.VIB, Dept Mol Biomed Res, Ghent, Belgium
2.Univ Ghent, Dept Mol Biol, B-9000 Ghent, Belgium
3.Beilinson Med Ctr, Liver Inst, Petah Tiqwa, Israel
4.Beilinson Med Ctr, Dept Med D, Petah Tiqwa, Israel
5.Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel
6.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100871, Peoples R China
7.Beilinson Med Ctr, Gastroenterol Unit, Rabin Med Ctr, Dept Histopathol, Petah Tiqwa, Israel
8.Beilinson Med Ctr, Epidemiol Unit, Dept Radiol, Rabin Med Ctr, Petah Tiqwa, Israel
9.Ghent Univ Hosp, Dept Gastroenterol & Hepatol, B-9000 Ghent, Belgium

Recommended Citation:
Chen, Cuiying,Schmilovtz-Weiss, Hemda,Liu, Xue-en,et al. Serum Protein N-Glycans Profiling for the Discovery of Potential Biomarkers for Nonalcoholic Steatohepatitis[J]. JOURNAL OF PROTEOME RESEARCH,2009,8(2):463-470.
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