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学科主题: 临床医学
题名:
Decreased Expression of Aquaporin-1 in Lung Tissue of Silicotic Rats
作者: Wang, Hongli1; Hao, Xiaohui2; Zhang, Li1; Liu, Shupeng2; Wang, Qian1; Liu, Nan1; Zhao, Jinyuan3; Jiang, Q.4,5; Liu, Heliang1,2
关键词: silicon dioxide ; silicosis ; aquaporin-1
刊名: CLINICAL LABORATORY
发表日期: 2015
DOI: 10.7754/Clin.Lab.2015.150223
卷: 61, 期:9, 页:1163-1169
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medical Laboratory Technology
研究领域[WOS]: Medical Laboratory Technology
关键词[WOS]: WATER CHANNEL ; AQP1 ; FIBROSIS ; PHYSIOLOGY ; MEMBRANE ; TARGETS
英文摘要:

Background: Aquaporin-1 (AQP-1), found in the early 1990s, a water channel protein in the cell membranes of mammals, has been reported to play an important role in water balance of the respiratory system. However, there are a few studies about the role of AQP in occupational pulmonary disease such as silicosis. This study is to explore the information of aquaporin-1 (AQP-1) in the pathogenesis of silicosis by examining AQP expression, distribution, and location in the lung tissue of a silicotic rat model.

Methods: Male Wistar SPF rats were divided randomly into the following 8 groups (n = 8 per group): (1) saline control group: instillation of 1 mL sterile physiological saline; (2) silica groups (1d, 7d, 14d, 28d, 42d, 56d): instillation of a suspension of 50 mg silica dust in a total volume of 1 mL sterile physiological saline; (3) the normal control group without treatment. Immunohistochemistry, immunofluorescence, and western blot were used to detect distribution and expression of AQP-1 in the lung tissue of rats exposed to silica.

Results: The expression of AQP-1 between normal and the saline control rats showed no significant difference, but was decreased in the silicotic model rats′ lung.

Conclusions: The expression of AQP-1 decreased in silicotic rats, which suggests that AQP-1 may play an important role in the formation of silicosis.

语种: 英语
WOS记录号: WOS:000361504500007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52990
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Hebei United Univ, Sch Publ Hlth, Tangshan 063000, Hebei Province, Peoples R China
2.Hebei United Univ, Med Res Ctr, Tangshan 063000, Hebei Province, Peoples R China
3.Peking Univ, Occupat Med Res Ctr, Hosp 3, Beijing 100191, Peoples R China
4.Thomas Jefferson Univ, Jefferson Med Coll, Dept Dermatol & Cutaneous Biol, Philadelphia, PA 19107 USA
5.Thomas Jefferson Univ, Jefferson Inst Mol Med, Philadelphia, PA 19107 USA

Recommended Citation:
Wang, Hongli,Hao, Xiaohui,Zhang, Li,et al. Decreased Expression of Aquaporin-1 in Lung Tissue of Silicotic Rats[J]. CLINICAL LABORATORY,2015,61(9):1163-1169.
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