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Follow-up of avidity and titre of anti-myeloperoxidase antibodies in sera from patients with propylthiouracil-induced vasculitis
Gao, Ying1; Chen, Min1; Ye, Hua1; Guo, Xiao-hui1; Zhao, Ming-hui1; Wang, Hai-yan1
刊名CLINICAL ENDOCRINOLOGY
2007-04-01
DOI10.1111/j.1365-2265.2007.02770.x
66期:4页:543-547
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism
研究领域[WOS]Endocrinology & Metabolism
关键词[WOS]ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES ; ANTITHYROID DRUGS ; CHINESE PATIENTS ; TARGET ANTIGENS ; GRAVES-DISEASE ; ANCA ; MYELOPEROXIDASE ; GLOMERULONEPHRITIS ; AUTOANTIBODIES ; CHILDREN
英文摘要

Objective Propylthiouracil (PTU) has been known to induce myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA) positive vasculitis. Our previous study indicated that the increase of avidity of MPO-ANCA might be associated with the occurrence of clinical vasculitis in patients with PTU-induced ANCA. The current study aimed to follow-up the avidity and titre of anti-MPO antibodies in sequential sera from patients with PTU-induced ANCA-associated systemic vasculitis (AASV).

Methods Six patients with PTU-induced vasculitis were enrolled in the current study. Serial sera in both active phase and in remission were collected. MPO-ANCA avidity was assessed by antigen-inhibition enzyme-linked immunosorbent assays (ELISAs), and avidity constant (aK) was determined as the reciprocal value of the MPO molar concentration in the liquid phase resulting in 50% inhibition of anti-MPO antibody binding to MPO in solid phase ELISA. Titres of MPO-ANCA were determined by using serial serum dilutions in MPO-ELISA.

Results After cessation of PTU and initiation of immunosuppressive therapy, the avidity and titre of MPO-ANCA decreased significantly during follow-up in sera from all the patients, and the avidity decreased much more quickly than the titres.

Conclusion Our study indicates that avidity of anti-MPO antibodies might be more closely associated with clinical vasculitis than titre.

语种英语
WOS记录号WOS:000244977600014
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被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52997
专题北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Hosp 1, Dept Nephrol, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Dept Endocrinol, Beijing 100034, Peoples R China
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GB/T 7714
Gao, Ying,Chen, Min,Ye, Hua,et al. Follow-up of avidity and titre of anti-myeloperoxidase antibodies in sera from patients with propylthiouracil-induced vasculitis[J]. CLINICAL ENDOCRINOLOGY,2007,66(4):543-547.
APA Gao, Ying,Chen, Min,Ye, Hua,Guo, Xiao-hui,Zhao, Ming-hui,&Wang, Hai-yan.(2007).Follow-up of avidity and titre of anti-myeloperoxidase antibodies in sera from patients with propylthiouracil-induced vasculitis.CLINICAL ENDOCRINOLOGY,66(4),543-547.
MLA Gao, Ying,et al."Follow-up of avidity and titre of anti-myeloperoxidase antibodies in sera from patients with propylthiouracil-induced vasculitis".CLINICAL ENDOCRINOLOGY 66.4(2007):543-547.
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