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Chemical Constituents from the Rhizomes of Smilax glabra and Their Antimicrobial Activity
Xu, Shuo1; Shang, Ming-Ying1; Liu, Guang-Xue1; Xu, Feng1; Wang, Xuan1; Shou, Cheng-Chao2; Cai, Shao-Qing1
关键词Smilax Glabra Phenylpropanoid-substituted Epicatechin Homoisoflavanone Stilbenes Antimicrobial Activity
刊名MOLECULES
2013-05-01
DOI10.3390/molecules18055265
18期:5页:5265-5287
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]PHENOLIC-COMPOUNDS ; MEDICINAL-PLANTS ; VITIS-AMURENSIS ; FLAVONOIDS ; CHROMATOGRAPHY ; DERIVATIVES ; GLYCERIDES ; INHIBITORS ; LIGNANS ; BULBS
英文摘要

Six new phenolic compounds, named smiglabrone A (1), smiglabrone B (2), smilachromanone (3), smiglastilbene (4), smiglactone (5), smiglabrol (6), together with fifty-seven known ones 7-63 were isolated from the rhizomes of Smilax glabra. Their structures were elucidated on the basis of extensive spectroscopic analyses, as well as by comparison with literature data. Twenty-seven of these compounds were obtained from and identified in the genus Smilax for the first time. The absolute configuration of (2S)-1,2-O-di-trans-p-coumaroylglycerol (43) was determined for the first time using the exciton-coupled circular dichroism (ECCD) method. Thirty isolated compounds were evaluated for their antimicrobial activity against three Gram-negative bacteria, three Gram-positive bacteria and one fungus, and the corresponding structure-activity relationships were also discussed. Eighteen compounds were found to be antimicrobial against the microorganisms tested and the minimum inhibitory concentrations (MIC) were in the range of 0.0794-3.09 mM. Among them, compound 1 showed antimicrobial activity against Canidia albicans with MIC value of 0.146 mM, which was stronger than cinchonain Ia with an MIC of 0.332 mM. Compounds 3 and 4 exhibited inhibitory activity against Staphylococcus aureus with MIC values of 0.303 and 0.205 mM, respectively. The results indicated that these antimicrobial constituents of this crude drug might be responsible for its clinical antimicrobial effect.

语种英语
WOS记录号WOS:000319446900030
项目编号2013ZX09508104
资助机构National Key Technology R&amp ; D Program "New Drug Innovation" of China
引用统计
被引频次:39[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52999
专题北京大学药学院
北京大学药学院_化学生物学系
北京大学药学院_天然药物学系
北京大学临床肿瘤学院_生化与分子生物学研究室
作者单位1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Peking Univ, Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Dept Biochem & Mol Biol,Minist Educ, Beijing 100142, Peoples R China
推荐引用方式
GB/T 7714
Xu, Shuo,Shang, Ming-Ying,Liu, Guang-Xue,et al. Chemical Constituents from the Rhizomes of Smilax glabra and Their Antimicrobial Activity[J]. MOLECULES,2013,18(5):5265-5287.
APA Xu, Shuo.,Shang, Ming-Ying.,Liu, Guang-Xue.,Xu, Feng.,Wang, Xuan.,...&Cai, Shao-Qing.(2013).Chemical Constituents from the Rhizomes of Smilax glabra and Their Antimicrobial Activity.MOLECULES,18(5),5265-5287.
MLA Xu, Shuo,et al."Chemical Constituents from the Rhizomes of Smilax glabra and Their Antimicrobial Activity".MOLECULES 18.5(2013):5265-5287.
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