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学科主题: 药学
题名:
Chemical Constituents from the Rhizomes of Smilax glabra and Their Antimicrobial Activity
作者: Xu, Shuo1; Shang, Ming-Ying1; Liu, Guang-Xue1; Xu, Feng1; Wang, Xuan1; Shou, Cheng-Chao2; Cai, Shao-Qing1
关键词: Smilax glabra ; phenylpropanoid-substituted epicatechin ; homoisoflavanone ; stilbenes ; antimicrobial activity
刊名: MOLECULES
发表日期: 2013-05-01
DOI: 10.3390/molecules18055265
卷: 18, 期:5, 页:5265-5287
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: PHENOLIC-COMPOUNDS ; MEDICINAL-PLANTS ; VITIS-AMURENSIS ; FLAVONOIDS ; CHROMATOGRAPHY ; DERIVATIVES ; GLYCERIDES ; INHIBITORS ; LIGNANS ; BULBS
英文摘要:

Six new phenolic compounds, named smiglabrone A (1), smiglabrone B (2), smilachromanone (3), smiglastilbene (4), smiglactone (5), smiglabrol (6), together with fifty-seven known ones 7-63 were isolated from the rhizomes of Smilax glabra. Their structures were elucidated on the basis of extensive spectroscopic analyses, as well as by comparison with literature data. Twenty-seven of these compounds were obtained from and identified in the genus Smilax for the first time. The absolute configuration of (2S)-1,2-O-di-trans-p-coumaroylglycerol (43) was determined for the first time using the exciton-coupled circular dichroism (ECCD) method. Thirty isolated compounds were evaluated for their antimicrobial activity against three Gram-negative bacteria, three Gram-positive bacteria and one fungus, and the corresponding structure-activity relationships were also discussed. Eighteen compounds were found to be antimicrobial against the microorganisms tested and the minimum inhibitory concentrations (MIC) were in the range of 0.0794-3.09 mM. Among them, compound 1 showed antimicrobial activity against Canidia albicans with MIC value of 0.146 mM, which was stronger than cinchonain Ia with an MIC of 0.332 mM. Compounds 3 and 4 exhibited inhibitory activity against Staphylococcus aureus with MIC values of 0.303 and 0.205 mM, respectively. The results indicated that these antimicrobial constituents of this crude drug might be responsible for its clinical antimicrobial effect.

语种: 英语
所属项目编号: 2013ZX09508104
项目资助者: National Key Technology R&amp ; D Program "New Drug Innovation" of China
WOS记录号: WOS:000319446900030
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52999
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Peking Univ, Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Dept Biochem & Mol Biol,Minist Educ, Beijing 100142, Peoples R China

Recommended Citation:
Xu, Shuo,Shang, Ming-Ying,Liu, Guang-Xue,et al. Chemical Constituents from the Rhizomes of Smilax glabra and Their Antimicrobial Activity[J]. MOLECULES,2013,18(5):5265-5287.
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