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学科主题: 药学
题名:
Kinetic distribution of paeoniflorin in cortex of normal and cerebral ischemia-reperfusion rats after intravenous administration of Paeoniae radix extract
作者: Cao, Chunai1; He, Xihui1; Wang, Wei1; Zhang, Lujun1; Lin, Han1; Du, Lijun1
关键词: paeoniflorin ; cortex ; ischemia-reperfusion ; blood-brain barrier ; HPLC
刊名: BIOMEDICAL CHROMATOGRAPHY
发表日期: 2006-12-01
DOI: 10.1002/bmc.658
卷: 20, 期:12, 页:1283-1288
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemical Research Methods ; Biochemistry & Molecular Biology ; Chemistry, Analytical ; Pharmacology & Pharmacy
研究领域[WOS]: Biochemistry & Molecular Biology ; Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: SCOPOLAMINE-INDUCED DEFICIT ; MAZE PERFORMANCE ; MAJOR CONSTITUENT ; DIAPHRAGM MUSCLE ; CRUDE DRUGS ; GLYCYRRHIZIN ; MOUSE ; ROOT ; INVOLVEMENT ; DERIVATIVES
英文摘要:

The time course of paeoniflorin in the cortex of normal and cerebral ischemia-reperfusion rats, following intravenous administration of Paeoniae Radix extract at a dose of 60 mg/kg of paeoniflorin, was determined using high-performance liquid chromatographic (HPLC) assay. The results showed that paeoniflorin could penetrate through the blood-brain barrier to reach the cortex, and that the injuries of ischemia-reperfusion could play an important role in pharmacokinetic process of paeoniflorin in the cortex after intravenous administration of Paeoniae Radix extract. The cortex concentrations of paconiflorin in cerebral ischemia-reperfusion rats were lower 5 min after dosing and declined more slowly than that in normal control. Copyright (c) 2006 John Wiley & Sons, Ltd.

语种: 英语
WOS记录号: WOS:000243541000002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53001
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Tsing Hua Univ, Dept Biol Sci & Biotechnol, Lab Pharmaceut Sci, Beijing 100084, Peoples R China
2.Peking Univ, Sch Pharm, Lab Chem Anal, Beijing 100094, Peoples R China

Recommended Citation:
Cao, Chunai,He, Xihui,Wang, Wei,et al. Kinetic distribution of paeoniflorin in cortex of normal and cerebral ischemia-reperfusion rats after intravenous administration of Paeoniae radix extract[J]. BIOMEDICAL CHROMATOGRAPHY,2006,20(12):1283-1288.
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