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Kinetic distribution of paeoniflorin in cortex of normal and cerebral ischemia-reperfusion rats after intravenous administration of Paeoniae radix extract
Cao, Chunai()1; He, Xihui()1; Wang, Wei()1; Zhang, Lujun()1; Lin, Han()1; Du, Lijun()1
Source PublicationBIOMEDICAL CHROMATOGRAPHY
2006-12-01
Volume20Issue:12Pages:1283-1288
Indexed BySCI
Abstract

The time course of paeoniflorin in the cortex of normal and cerebral ischemia-reperfusion rats, following intravenous administration of Paeoniae Radix extract at a dose of 60 mg/kg of paeoniflorin, was determined using high-performance liquid chromatographic (HPLC) assay. The results showed that paeoniflorin could penetrate through the blood-brain barrier to reach the cortex, and that the injuries of ischemia-reperfusion could play an important role in pharmacokinetic process of paeoniflorin in the cortex after intravenous administration of Paeoniae Radix extract. The cortex concentrations of paconiflorin in cerebral ischemia-reperfusion rats were lower 5 min after dosing and declined more slowly than that in normal control. Copyright (c) 2006 John Wiley & Sons, Ltd.

KeywordPaeoniflorin Cortex Ischemia-reperfusion Blood-brain Barrier Hplc
Subject Area药学
SubtypeArticle
DOI10.1002/bmc.658
WOS HeadingsScience & Technology
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry ; Pharmacology & Pharmacy
WOS SubjectBiochemical Research Methods ; Biochemistry & Molecular Biology ; Chemistry, Analytical ; Pharmacology & Pharmacy
WOS KeywordSCOPOLAMINE-INDUCED DEFICIT ; MAZE PERFORMANCE ; MAJOR CONSTITUENT ; DIAPHRAGM MUSCLE ; CRUDE DRUGS ; GLYCYRRHIZIN ; MOUSE ; ROOT ; INVOLVEMENT ; DERIVATIVES
WOS IDWOS:000243541000002
Citation statistics
Cited Times:17[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.bjmu.edu.cn/handle/400002259/53001
Collection北京大学药学院
Affiliation1.Tsing Hua Univ, Dept Biol Sci & Biotechnol, Lab Pharmaceut Sci, Beijing 100084, Peoples R China
2.Peking Univ, Sch Pharm, Lab Chem Anal, Beijing 100094, Peoples R China
Recommended Citation
GB/T 7714
Cao, Chunai,He, Xihui,Wang, Wei,et al. Kinetic distribution of paeoniflorin in cortex of normal and cerebral ischemia-reperfusion rats after intravenous administration of Paeoniae radix extract[J]. BIOMEDICAL CHROMATOGRAPHY,2006,20(12):1283-1288.
APA Cao, Chunai,He, Xihui,Wang, Wei,Zhang, Lujun,Lin, Han,&Du, Lijun.(2006).Kinetic distribution of paeoniflorin in cortex of normal and cerebral ischemia-reperfusion rats after intravenous administration of Paeoniae radix extract.BIOMEDICAL CHROMATOGRAPHY,20(12),1283-1288.
MLA Cao, Chunai,et al."Kinetic distribution of paeoniflorin in cortex of normal and cerebral ischemia-reperfusion rats after intravenous administration of Paeoniae radix extract".BIOMEDICAL CHROMATOGRAPHY 20.12(2006):1283-1288.
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