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Kinetic distribution of paeoniflorin in cortex of normal and cerebral ischemia-reperfusion rats after intravenous administration of Paeoniae radix extract
Cao, Chunai1; He, Xihui1; Wang, Wei1; Zhang, Lujun1; Lin, Han1; Du, Lijun1
关键词Paeoniflorin Cortex Ischemia-reperfusion Blood-brain Barrier Hplc
刊名BIOMEDICAL CHROMATOGRAPHY
2006-12-01
DOI10.1002/bmc.658
20期:12页:1283-1288
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemical Research Methods ; Biochemistry & Molecular Biology ; Chemistry, Analytical ; Pharmacology & Pharmacy
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry ; Pharmacology & Pharmacy
关键词[WOS]SCOPOLAMINE-INDUCED DEFICIT ; MAZE PERFORMANCE ; MAJOR CONSTITUENT ; DIAPHRAGM MUSCLE ; CRUDE DRUGS ; GLYCYRRHIZIN ; MOUSE ; ROOT ; INVOLVEMENT ; DERIVATIVES
英文摘要

The time course of paeoniflorin in the cortex of normal and cerebral ischemia-reperfusion rats, following intravenous administration of Paeoniae Radix extract at a dose of 60 mg/kg of paeoniflorin, was determined using high-performance liquid chromatographic (HPLC) assay. The results showed that paeoniflorin could penetrate through the blood-brain barrier to reach the cortex, and that the injuries of ischemia-reperfusion could play an important role in pharmacokinetic process of paeoniflorin in the cortex after intravenous administration of Paeoniae Radix extract. The cortex concentrations of paconiflorin in cerebral ischemia-reperfusion rats were lower 5 min after dosing and declined more slowly than that in normal control. Copyright (c) 2006 John Wiley & Sons, Ltd.

语种英语
WOS记录号WOS:000243541000002
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53001
专题北京大学药学院
作者单位1.Tsing Hua Univ, Dept Biol Sci & Biotechnol, Lab Pharmaceut Sci, Beijing 100084, Peoples R China
2.Peking Univ, Sch Pharm, Lab Chem Anal, Beijing 100094, Peoples R China
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GB/T 7714
Cao, Chunai,He, Xihui,Wang, Wei,et al. Kinetic distribution of paeoniflorin in cortex of normal and cerebral ischemia-reperfusion rats after intravenous administration of Paeoniae radix extract[J]. BIOMEDICAL CHROMATOGRAPHY,2006,20(12):1283-1288.
APA Cao, Chunai,He, Xihui,Wang, Wei,Zhang, Lujun,Lin, Han,&Du, Lijun.(2006).Kinetic distribution of paeoniflorin in cortex of normal and cerebral ischemia-reperfusion rats after intravenous administration of Paeoniae radix extract.BIOMEDICAL CHROMATOGRAPHY,20(12),1283-1288.
MLA Cao, Chunai,et al."Kinetic distribution of paeoniflorin in cortex of normal and cerebral ischemia-reperfusion rats after intravenous administration of Paeoniae radix extract".BIOMEDICAL CHROMATOGRAPHY 20.12(2006):1283-1288.
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