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学科主题临床医学
"Intensity-Response" Effects of Electroacupuncture on Gastric Motility and Its Underlying Peripheral Neural Mechanism
Su, Yang-Shuai1; He, Wei1; Wang, Chi2; Shi, Hong1; Zhao, Yu-Feng3; Xin, Juan-Juan1; Wang, Xiao-Yu1; Shang, Hong-Yan1; Hu, Ling1; Jing, Xiang-Hong1; Zhu, Bing1
刊名EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
2013
DOI10.1155/2013/535742
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Integrative & Complementary Medicine
研究领域[WOS]Integrative & Complementary Medicine
关键词[WOS]FUNCTIONAL GASTROINTESTINAL DISORDERS ; A-DELTA-FIBER ; ANESTHETIZED RATS ; REFLEX INHIBITION ; CONSCIOUS RATS ; C-FIBER ; ACUPUNCTURE ; STIMULATION ; MUSCLE ; SUPPRESSION
英文摘要

The aim of this study was to explore the "intensity-response" relationship between EAS and the effect of gastric motility of rats and its underlying peripheral neural mechanism by employing ASIC3 knockout (ASIC3-/-), TRPV1 knockout (TRPV1-/-), and C57BL/6 mice. For adult male Sprague-Dawley (n = 18) rats, the intensities of EAS were 0.5, 1, 3, 5, 7, and 9 mA, respectively. For mice (n = 8 in each group), only 1 mA was used, by which C fiber of the mice can be activated. Gastric antrum motility was measured by intrapyloric balloon. Gastric motility was facilitated by EAS at ST36 and inhibited by EAS at CV12. The half maximal facilitation intensity of EAS at ST36 was 2.1-2.3 mA, and the half maximal inhibitory intensity of EAS at CV12 was 2.8 mA. In comparison with C57BL/6 mice, the facilitatory effect of ST36 and inhibitive effect of CV12 in ASIC3-/- mice decreased, but the difference was not statistically significant (P > 0.05). However, these effects in TRPV1-/- mice decreased significantly (P < 0.001). The results indicated that there existed an "intensity-response" relationship between EAS and the effect of gastric motility. TRPV1 receptor was involved in the regulation of gastric motility of EAS.

语种英语
WOS记录号WOS:000321830700001
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53006
专题北京大学第一临床医学院_消化科
作者单位1.China Acad Chinese Med Sci, Inst Acupuncture & Moxibust, Beijing 100700, Peoples R China
2.Peking Univ, Hosp 1, Dept Gastroenterol, Beijing 100034, Peoples R China
3.China Acad Chinese Med Sci, Inst Basic & Clin Med, Beijing 100700, Peoples R China
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GB/T 7714
Su, Yang-Shuai,He, Wei,Wang, Chi,et al. "Intensity-Response" Effects of Electroacupuncture on Gastric Motility and Its Underlying Peripheral Neural Mechanism[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2013.
APA Su, Yang-Shuai.,He, Wei.,Wang, Chi.,Shi, Hong.,Zhao, Yu-Feng.,...&Zhu, Bing.(2013)."Intensity-Response" Effects of Electroacupuncture on Gastric Motility and Its Underlying Peripheral Neural Mechanism.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE.
MLA Su, Yang-Shuai,et al.""Intensity-Response" Effects of Electroacupuncture on Gastric Motility and Its Underlying Peripheral Neural Mechanism".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2013).
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