北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 消化内科  > 期刊论文
学科主题: 临床医学
题名:
"Intensity-Response" Effects of Electroacupuncture on Gastric Motility and Its Underlying Peripheral Neural Mechanism
作者: Su, Yang-Shuai1; He, Wei1; Wang, Chi2; Shi, Hong1; Zhao, Yu-Feng3; Xin, Juan-Juan1; Wang, Xiao-Yu1; Shang, Hong-Yan1; Hu, Ling1; Jing, Xiang-Hong1; Zhu, Bing1
刊名: EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
发表日期: 2013
DOI: 10.1155/2013/535742
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Integrative & Complementary Medicine
研究领域[WOS]: Integrative & Complementary Medicine
关键词[WOS]: FUNCTIONAL GASTROINTESTINAL DISORDERS ; A-DELTA-FIBER ; ANESTHETIZED RATS ; REFLEX INHIBITION ; CONSCIOUS RATS ; C-FIBER ; ACUPUNCTURE ; STIMULATION ; MUSCLE ; SUPPRESSION
英文摘要:

The aim of this study was to explore the "intensity-response" relationship between EAS and the effect of gastric motility of rats and its underlying peripheral neural mechanism by employing ASIC3 knockout (ASIC3-/-), TRPV1 knockout (TRPV1-/-), and C57BL/6 mice. For adult male Sprague-Dawley (n = 18) rats, the intensities of EAS were 0.5, 1, 3, 5, 7, and 9 mA, respectively. For mice (n = 8 in each group), only 1 mA was used, by which C fiber of the mice can be activated. Gastric antrum motility was measured by intrapyloric balloon. Gastric motility was facilitated by EAS at ST36 and inhibited by EAS at CV12. The half maximal facilitation intensity of EAS at ST36 was 2.1-2.3 mA, and the half maximal inhibitory intensity of EAS at CV12 was 2.8 mA. In comparison with C57BL/6 mice, the facilitatory effect of ST36 and inhibitive effect of CV12 in ASIC3-/- mice decreased, but the difference was not statistically significant (P > 0.05). However, these effects in TRPV1-/- mice decreased significantly (P < 0.001). The results indicated that there existed an "intensity-response" relationship between EAS and the effect of gastric motility. TRPV1 receptor was involved in the regulation of gastric motility of EAS.

语种: 英语
所属项目编号: 2011CB505201 ; 2010CB530507 ; 81173205 ; 7132148
项目资助者: National Key Basic Research Program 973 ; National Natural Science Foundation of China ; Beijing Natural Science Foundation
WOS记录号: WOS:000321830700001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53006
Appears in Collections:北京大学第一临床医学院_消化内科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.China Acad Chinese Med Sci, Inst Acupuncture & Moxibust, Beijing 100700, Peoples R China
2.Peking Univ, Hosp 1, Dept Gastroenterol, Beijing 100034, Peoples R China
3.China Acad Chinese Med Sci, Inst Basic & Clin Med, Beijing 100700, Peoples R China

Recommended Citation:
Su, Yang-Shuai,He, Wei,Wang, Chi,et al. "Intensity-Response" Effects of Electroacupuncture on Gastric Motility and Its Underlying Peripheral Neural Mechanism[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2013.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Su, Yang-Shuai]'s Articles
[He, Wei]'s Articles
[Wang, Chi]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Su, Yang-Shuai]‘s Articles
[He, Wei]‘s Articles
[Wang, Chi]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace