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学科主题: 临床医学
题名:
Factor analysis of diabetic retinopathy in Chinese patients
作者: Zheng, Weiwei
关键词: Diabetic retinopathy ; Factor analysis ; Multicollinearity
刊名: DIABETES RESEARCH AND CLINICAL PRACTICE
发表日期: 2011-05-01
DOI: 10.1016/j.diabres.2011.02.007
卷: 92, 期:2, 页:244-252
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: INTENSIVE MEDICAL THERAPY ; ISCHEMIC-HEART-DISEASE ; BETA-CELL FUNCTION ; RISK-FACTORS ; MICROVASCULAR COMPLICATIONS ; CARDIOVASCULAR-DISEASE ; BLOOD-PRESSURE ; C-PEPTIDE ; PROGRESSION ; MELLITUS
英文摘要:

Objective: To investigate factors related to diabetic retinopathy (DR).

Method: Clinical data of 603 Chinese diabetic patients were analyzed retrospectively. On the basis of its severity, DR was graded as non-diabetic retinopathy (NDR), non proliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR). Factor analysis was conducted and factor scores were used as independent variables in both Logistic and Ordinal regression models to identify the predictors of the development and/or progression of DR.

Result: After factor analysis, 21 original variables were finally reduced to eight unique factors, representing obesity, glycemic, C peptide, lipids, time, renal, blood pressure and metabolic factors. Logistic regression revealed that female (OR = 2.208, 95%CI 1.328-3.671), comorbidity of peripheral atherosclerosis (PA) (OR = 2.690, 95%CI 1.000-7.238), time factor (OR = 1.838, 95%CI 1.421-2.377) and renal factor (OR = 2.444, 95%CI 1.757-3.400) were positively associated with DR, while C peptide factor (OR = 0.469, 95%CI 0.365-0.604) was negatively associated with DR. Besides another negatively related obesity factor (OR = 0.777), Ordinal regression revealed similarly related factors, but ruled out the influence of gender and PA.

Conclusion: Female, macrovascular complications, time and renal factors are predictors of DR, while C peptide factor is negatively associated with the development and/or progression of DR. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000290612200018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53016
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: Peking Univ, Dept Emergency, Peoples Hosp, Beijing 100044, Peoples R China

Recommended Citation:
Zheng, Weiwei. Factor analysis of diabetic retinopathy in Chinese patients[J]. DIABETES RESEARCH AND CLINICAL PRACTICE,2011,92(2):244-252.
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