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Factor analysis of diabetic retinopathy in Chinese patients
Zheng, Weiwei
关键词Diabetic Retinopathy Factor Analysis Multicollinearity
刊名DIABETES RESEARCH AND CLINICAL PRACTICE
2011-05-01
DOI10.1016/j.diabres.2011.02.007
92期:2页:244-252
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism
研究领域[WOS]Endocrinology & Metabolism
关键词[WOS]INTENSIVE MEDICAL THERAPY ; ISCHEMIC-HEART-DISEASE ; BETA-CELL FUNCTION ; RISK-FACTORS ; MICROVASCULAR COMPLICATIONS ; CARDIOVASCULAR-DISEASE ; BLOOD-PRESSURE ; C-PEPTIDE ; PROGRESSION ; MELLITUS
英文摘要

Objective: To investigate factors related to diabetic retinopathy (DR).

Method: Clinical data of 603 Chinese diabetic patients were analyzed retrospectively. On the basis of its severity, DR was graded as non-diabetic retinopathy (NDR), non proliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR). Factor analysis was conducted and factor scores were used as independent variables in both Logistic and Ordinal regression models to identify the predictors of the development and/or progression of DR.

Result: After factor analysis, 21 original variables were finally reduced to eight unique factors, representing obesity, glycemic, C peptide, lipids, time, renal, blood pressure and metabolic factors. Logistic regression revealed that female (OR = 2.208, 95%CI 1.328-3.671), comorbidity of peripheral atherosclerosis (PA) (OR = 2.690, 95%CI 1.000-7.238), time factor (OR = 1.838, 95%CI 1.421-2.377) and renal factor (OR = 2.444, 95%CI 1.757-3.400) were positively associated with DR, while C peptide factor (OR = 0.469, 95%CI 0.365-0.604) was negatively associated with DR. Besides another negatively related obesity factor (OR = 0.777), Ordinal regression revealed similarly related factors, but ruled out the influence of gender and PA.

Conclusion: Female, macrovascular complications, time and renal factors are predictors of DR, while C peptide factor is negatively associated with the development and/or progression of DR. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000290612200018
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53016
专题北京大学第二临床医学院
作者单位Peking Univ, Dept Emergency, Peoples Hosp, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Zheng, Weiwei. Factor analysis of diabetic retinopathy in Chinese patients[J]. DIABETES RESEARCH AND CLINICAL PRACTICE,2011,92(2):244-252.
APA Zheng, Weiwei.(2011).Factor analysis of diabetic retinopathy in Chinese patients.DIABETES RESEARCH AND CLINICAL PRACTICE,92(2),244-252.
MLA Zheng, Weiwei."Factor analysis of diabetic retinopathy in Chinese patients".DIABETES RESEARCH AND CLINICAL PRACTICE 92.2(2011):244-252.
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