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学科主题: 公共卫生
题名:
Effects of ginsenoside Rg1 on postimplantation rat and mouse embryos cultured in vitro
作者: Liu, P1; Yin, HJ1; Xu, YJ1; Zhang, ZF1; Chen, KJ1; Li, Y1
关键词: embryotoxicity ; ginseng ; ginsenoside Rg1 ; whole embryo culture
刊名: TOXICOLOGY IN VITRO
发表日期: 2006-03-01
DOI: 10.1016/j.tiv.2005.06.029
卷: 20, 期:2, 页:234-238
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Toxicology
研究领域[WOS]: Toxicology
关键词[WOS]: PANAX-GINSENG
英文摘要:

GRg1 is one of the most important active agents extracted from ginseng. Although there are numerous reports in the medical literature concerning the beneficial effects of GRg1, little is known about its effects on embryonic development. In our study, whole embryo culture was applied to explore the effects of GRg1 on SD rat and ICR mouse embryos during their critical period of organogenesis. All embryos were exposed to different concentrations of GRg1, and scored for their growth and differentiation at the end of the 48-h culture period. Total morphological score decreased significantly at the concentration of GRg1 of 50 mu g/ml to mice and at 30 mu g/ml to rats. The whole embryonic growth was affected, represented as reduced crown-rump length and head length, and decreased number of somites from 10 mu g/ml both in mice and rats. Morphological development was influenced relatively late. To rats, the scores of flexion, forelimb bud and hindlimb bud were significantly reduced at 30 mu g/ml, and heart was among the affected organs. However, the effect on heart was not observed in mice, and flexion and limb buds were influenced at 50 mu g/ml. These results demonstrate that GRg1 has embryotoxicity during both rat and mouse organogenetic period and rats might be more sensitive than mice. We suggest that pregnant women of first trimester should use ginseng with caution before the exact conclusion is obtained. (c) 2005 Elsevier Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000236161300010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53023
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Dept Nutr & Food Hyg, Sch Publ Hlth, Beijing 100083, Peoples R China
2.Chinese Acad Tradit Chinese Med, Beijing 100091, Peoples R China

Recommended Citation:
Liu, P,Yin, HJ,Xu, YJ,et al. Effects of ginsenoside Rg1 on postimplantation rat and mouse embryos cultured in vitro[J]. TOXICOLOGY IN VITRO,2006,20(2):234-238.
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