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学科主题基础医学
Localization of hyaluronan in the optic pathway of mouse embryos
Lin, Ling1; Wang, Jun1; Chan, Chung-Kit1; Chan, Sun-On1
关键词Axon Guidance Cd44 Extracellular Matrix Midline Retina
刊名NEUROREPORT
2007-03-05
18期:4页:355-358
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]RETINAL GANGLION-CELLS ; RETINOFUGAL PATHWAY ; CHONDROITIN SULFATE ; ENZYMATIC REMOVAL ; AXON GROWTH ; CHIASM ; CD44 ; EXPRESSION ; NEUROCAN ; PHOSPHACAN
英文摘要

CD44 has been shown to be involved in midline crossing and the generation of ipsilateral projections in the mouse optic chiasm. To determine whether these functions involve hyaluronan, the major ligand of CD44, we examined localization of hyaluronan in the mouse optic pathway. Hyaluronan was deposited mainly in vitreal regions of the retina and the optic disk. In ventral diencephalon, it was localized largely on the chiasmatic neurons that project processes to the chiasmatic midline and the optic tract. Colocalization of hyaluronan and CD44 was observed only in the midline but not lateral domains of the chiasmatic neurons, suggesting a hyaluronan/CD44-mediated mechanism that controls axon routing at the midline but not at the optic tract and the retina.

语种英语
WOS记录号WOS:000244909600011
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53024
专题基础医学院
作者单位1.Chinese Univ Hong Kong, Dept Anat, Shatin, Hong Kong, Peoples R China
2.Peking Univ, Dept Anat & Embryol, Sch Basic Med Sci, Beijing 100871, Peoples R China
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GB/T 7714
Lin, Ling,Wang, Jun,Chan, Chung-Kit,et al. Localization of hyaluronan in the optic pathway of mouse embryos[J]. NEUROREPORT,2007,18(4):355-358.
APA Lin, Ling,Wang, Jun,Chan, Chung-Kit,&Chan, Sun-On.(2007).Localization of hyaluronan in the optic pathway of mouse embryos.NEUROREPORT,18(4),355-358.
MLA Lin, Ling,et al."Localization of hyaluronan in the optic pathway of mouse embryos".NEUROREPORT 18.4(2007):355-358.
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