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学科主题: 基础医学
题名:
Localization of hyaluronan in the optic pathway of mouse embryos
作者: Lin, Ling1; Wang, Jun1; Chan, Chung-Kit1; Chan, Sun-On1
关键词: axon guidance ; CD44 ; extracellular matrix ; midline ; retina
刊名: NEUROREPORT
发表日期: 2007-03-05
卷: 18, 期:4, 页:355-358
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: RETINAL GANGLION-CELLS ; RETINOFUGAL PATHWAY ; CHONDROITIN SULFATE ; ENZYMATIC REMOVAL ; AXON GROWTH ; CHIASM ; CD44 ; EXPRESSION ; NEUROCAN ; PHOSPHACAN
英文摘要:

CD44 has been shown to be involved in midline crossing and the generation of ipsilateral projections in the mouse optic chiasm. To determine whether these functions involve hyaluronan, the major ligand of CD44, we examined localization of hyaluronan in the mouse optic pathway. Hyaluronan was deposited mainly in vitreal regions of the retina and the optic disk. In ventral diencephalon, it was localized largely on the chiasmatic neurons that project processes to the chiasmatic midline and the optic tract. Colocalization of hyaluronan and CD44 was observed only in the midline but not lateral domains of the chiasmatic neurons, suggesting a hyaluronan/CD44-mediated mechanism that controls axon routing at the midline but not at the optic tract and the retina.

语种: 英语
WOS记录号: WOS:000244909600011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53024
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Chinese Univ Hong Kong, Dept Anat, Shatin, Hong Kong, Peoples R China
2.Peking Univ, Dept Anat & Embryol, Sch Basic Med Sci, Beijing 100871, Peoples R China

Recommended Citation:
Lin, Ling,Wang, Jun,Chan, Chung-Kit,et al. Localization of hyaluronan in the optic pathway of mouse embryos[J]. NEUROREPORT,2007,18(4):355-358.
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