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学科主题口腔医学
Effect of systemic antibiotics on clinical and patient-reported outcomes of implant therapy - a multicenter randomized controlled clinical trial
Tan, Wah Ching1; Ong, Marianne1; Han, Jie2; Mattheos, Nikos3,4; Pjetursson, Bjarni E.5; Tsai, Alex Yi-Min6; Sanz, Ignacio7; Wong, May C. M.4; Lang, Niklaus P.4; ITI Antibiotic Study Grp1
关键词Complications Dental Implants Failures Implant Dentistry Patient-reported Outcomes Success Survival Systemic Antibiotics
刊名CLINICAL ORAL IMPLANTS RESEARCH
2014-02-01
DOI10.1111/clr.12098
25期:2页:185-193
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine ; Engineering, Biomedical
研究领域[WOS]Dentistry, Oral Surgery & Medicine ; Engineering
关键词[WOS]DENTAL IMPLANTS ; PROPHYLACTIC ANTIBIOTICS ; SPONTANEOUS PROGRESSION ; PERI-IMPLANTITIS ; SURGERY ; PLACEMENT ; INFECTION ; SURFACES ; DOGS
英文摘要

ObjectivesTo determine the effect of various systemic antibiotic prophylaxis regimes on patient-reported outcomes and postsurgical complications in patients undergoing conventional implant installation.

Material and methodsThree hundred and twenty-nine healthy adults in need of conventional implant installation were randomly assigned to one of four groups: (i) preoperatively 2g of amoxycillin 1h before surgery (positive control, PC), (ii) postoperatively 2g of amoxycillin immediately following surgery (test 1, T1), (iii) preoperatively 2g of amoxycillin 1h before and 500mg thrice daily on days 2 and 3 after surgery (test 2, T2), (iv) preoperatively 2g of placebo 1h before surgery (negative control, NC). Subjects were examined clinically by blinded examiners over 8weeks after implant installation. In addition, Visual Analogue Scales (VAS) for pain, swelling, bruising and bleeding were obtained over 14days. ANOVA was performed for the VAS. Chi-square tests were applied for postsurgical complications.

ResultsAll VAS scores were low for all groups and decreased over time (P<0.001). There were no significant differences for the VAS scores between the various groups at any time point (P>0.05). There was only a significant difference in flap closure at week 4, where NC had 5% of the subjects not achieving complete wound closure compared to 0% for the three other groups (P=0.01), with no other significant differences for any postsurgical complications (P>0.05).

ConclusionFor standard single implant placement, prophylactic systemic antibiotics either before or after, or before and after the surgical procedure do not improve patient-reported outcomes or prevalence of postsurgical complications.

语种英语
WOS记录号WOS:000329461200033
项目编号616-2009
资助机构ITI Foundation ; Clinical Research Foundation (CRF) for the Promotion of Oral Health, Brienz, Switzerland
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53028
专题北京大学口腔医学院
作者单位1.Univ Iceland, Fac Odontol, Reykjavik, Iceland
2.Univ Complutense Madrid, Madrid, Spain
3.Griffith Univ, Gold Coast, Qld, Australia
4.Natl Dent Ctr Singapore, Singapore 168938, Singapore
5.Peking Univ, Sch Stomatol, Beijing 100871, Peoples R China
6.Univ Hong Kong, Fac Dent, Hong Kong, Hong Kong, Peoples R China
7.Natl Taiwan Univ, Sch Dent Med, Dept Periodontol, Taipei 10764, Taiwan
推荐引用方式
GB/T 7714
Tan, Wah Ching,Ong, Marianne,Han, Jie,et al. Effect of systemic antibiotics on clinical and patient-reported outcomes of implant therapy - a multicenter randomized controlled clinical trial[J]. CLINICAL ORAL IMPLANTS RESEARCH,2014,25(2):185-193.
APA Tan, Wah Ching.,Ong, Marianne.,Han, Jie.,Mattheos, Nikos.,Pjetursson, Bjarni E..,...&ITI Antibiotic Study Grp.(2014).Effect of systemic antibiotics on clinical and patient-reported outcomes of implant therapy - a multicenter randomized controlled clinical trial.CLINICAL ORAL IMPLANTS RESEARCH,25(2),185-193.
MLA Tan, Wah Ching,et al."Effect of systemic antibiotics on clinical and patient-reported outcomes of implant therapy - a multicenter randomized controlled clinical trial".CLINICAL ORAL IMPLANTS RESEARCH 25.2(2014):185-193.
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