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学科主题临床医学
Apolipoprotein E gene polymorphism and its association with human longevity in the Uygur nationality in Xinjiang
Wang, XL1; Wang, GQ1; Yang, CR1; Li, X1
关键词Apolipoprotein e Gene Longevity Uygur
刊名CHINESE MEDICAL JOURNAL
2001-08-01
114期:8页:817-820
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
英文摘要

Objective To study the relationship between apoE alleles and life-span.

Methods Apolipoprotein E genotypes were determined in 164 unrelated Uygurs including 35 persons aged 90 years or older, 71 men aged 20-35 and 54 men with myocardial infarction by using polymerase chain reaction-restriction fragment length polymorphism. Apolipoprotein E gene polymorphism was analyzed among three groups.

Results There was statistically significant difference in the epsilon4 allele frequencies among three groups. The epsilon4 allele frequency in olds was the lowest (0.057), while in patients suffering from myocardial infarction (MI) was the highest (0.213). In MI patients the average age of first attack in epsilon4 allele carriers was significantly younger than that of non-carries, 51.3 and 58.3 years, respectively (P < 0.05).

Conclusion ApoE genotype may have some impact on human longevity.

语种英语
WOS记录号WOS:000170838400008
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53034
专题北京大学第三临床医学院_儿科
北京大学第一临床医学院_感染疾病科
作者单位1.Beijing Univ, Teaching Hosp 3, Dept Pediat, Beijing 100083, Peoples R China
2.Xinjiang Med Univ, Dept Environm Hlth, Urumqi 830054, Peoples R China
3.First Teaching Hosp, Urumqi 830054, Peoples R China
4.Xinjiang Med Univ, Urumqi 830054, Peoples R China
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GB/T 7714
Wang, XL,Wang, GQ,Yang, CR,et al. Apolipoprotein E gene polymorphism and its association with human longevity in the Uygur nationality in Xinjiang[J]. CHINESE MEDICAL JOURNAL,2001,114(8):817-820.
APA Wang, XL,Wang, GQ,Yang, CR,&Li, X.(2001).Apolipoprotein E gene polymorphism and its association with human longevity in the Uygur nationality in Xinjiang.CHINESE MEDICAL JOURNAL,114(8),817-820.
MLA Wang, XL,et al."Apolipoprotein E gene polymorphism and its association with human longevity in the Uygur nationality in Xinjiang".CHINESE MEDICAL JOURNAL 114.8(2001):817-820.
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