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学科主题: 临床医学
题名:
Apolipoprotein E gene polymorphism and its association with human longevity in the Uygur nationality in Xinjiang
作者: Wang, XL1; Wang, GQ1; Yang, CR1; Li, X1
关键词: apolipoprotein E ; gene ; longevity ; Uygur
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2001-08-01
卷: 114, 期:8, 页:817-820
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
英文摘要:

Objective To study the relationship between apoE alleles and life-span.

Methods Apolipoprotein E genotypes were determined in 164 unrelated Uygurs including 35 persons aged 90 years or older, 71 men aged 20-35 and 54 men with myocardial infarction by using polymerase chain reaction-restriction fragment length polymorphism. Apolipoprotein E gene polymorphism was analyzed among three groups.

Results There was statistically significant difference in the epsilon4 allele frequencies among three groups. The epsilon4 allele frequency in olds was the lowest (0.057), while in patients suffering from myocardial infarction (MI) was the highest (0.213). In MI patients the average age of first attack in epsilon4 allele carriers was significantly younger than that of non-carries, 51.3 and 58.3 years, respectively (P < 0.05).

Conclusion ApoE genotype may have some impact on human longevity.

语种: 英语
WOS记录号: WOS:000170838400008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53034
Appears in Collections:北京大学第三临床医学院_儿科_期刊论文

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作者单位: 1.Beijing Univ, Teaching Hosp 3, Dept Pediat, Beijing 100083, Peoples R China
2.Xinjiang Med Univ, Dept Environm Hlth, Urumqi 830054, Peoples R China
3.First Teaching Hosp, Urumqi 830054, Peoples R China
4.Xinjiang Med Univ, Urumqi 830054, Peoples R China

Recommended Citation:
Wang, XL,Wang, GQ,Yang, CR,et al. Apolipoprotein E gene polymorphism and its association with human longevity in the Uygur nationality in Xinjiang[J]. CHINESE MEDICAL JOURNAL,2001,114(8):817-820.
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