IR@PKUHSC  > 北京大学第三临床医学院
学科主题临床医学
Organic Selenium Supplementation Increases Mercury Excretion and Decreases Oxidative Damage in Long-Term Mercury-Exposed Residents from Wanshan, China
Li, Yu-Feng2,3; Dong, Zeqin4; Chen, Chunying1; Li, Bai2,3; Gao, Yuxi2,3; Qu, Liya4; Wang, Tianchen5; Fu, Xin6; Zhao, Yuliang2,3; Chai, Zhifang2,3
刊名ENVIRONMENTAL SCIENCE & TECHNOLOGY
2012-10-16
DOI10.1021/es302241v
46期:20页:11313-11318
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Engineering, Environmental ; Environmental Sciences
资助者K. C. Wong Education Foundation, Hong Kong ; CAS Youth Innovation Association ; Chinese Academy of Sciences ; Natural Science Foundation of China ; K. C. Wong Education Foundation, Hong Kong ; CAS Youth Innovation Association ; Chinese Academy of Sciences ; Natural Science Foundation of China
研究领域[WOS]Engineering ; Environmental Sciences & Ecology
关键词[WOS]HPLC-ICP-MS ; METHYL MERCURY ; DNA-DAMAGE ; GLUTATHIONE-PEROXIDASE ; INORGANIC MERCURY ; ENRICHED YEAST ; IN-VIVO ; TOXICITY ; METHYLMERCURY ; AREAS
英文摘要

Due to a long history of extensive mercury mining and smelting activities, local residents in Wanshan, China, are suffering from elevated mercury exposure. The objective of the present study was to study the effects of oral supplementation with selenium-enriched yeast in these long-term mercury-exposed populations. One hundred and three volunteers from Wanshan area were recruited and 53 of them were supplemented with 100 mu g of organic selenium daily as selenium-enriched yeast while 50 of them were supplemented with the nonselenium-enriched yeast for 3 months. The effects of selenium supplementation on urinary mercury, selenium, and oxidative stress-related biomarkers including malondialdehyde and 8-ydroxy-2-deoxyguanosine were assessed. This 3-month selenium supplementation trial indicated that organic selenium supplementation could increase mercury excretion and decrease urinary malondialdehyde and 8-hydroxy-2-deoxyguanosine levels in local residents.

语种英语
所属项目编号20931160430 ; 1120568
资助者K. C. Wong Education Foundation, Hong Kong ; CAS Youth Innovation Association ; Chinese Academy of Sciences ; Natural Science Foundation of China ; K. C. Wong Education Foundation, Hong Kong ; CAS Youth Innovation Association ; Chinese Academy of Sciences ; Natural Science Foundation of China
WOS记录号WOS:000309805000060
引用统计
被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53042
专题北京大学第三临床医学院
作者单位1.Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst High Energy Phys, Multidiscipline Initiat Ctr, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Nucl Analyt Tech, Beijing 100049, Peoples R China
4.Guizhou Inst Environm Sci & Designing, Guiyang 550002, Peoples R China
5.Peking Univ, Hosp 3, Beijing 100191, Peoples R China
6.Uppsala Univ, SE-75105 Uppsala, Sweden
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Li, Yu-Feng,Dong, Zeqin,Chen, Chunying,et al. Organic Selenium Supplementation Increases Mercury Excretion and Decreases Oxidative Damage in Long-Term Mercury-Exposed Residents from Wanshan, China[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2012,46(20):11313-11318.
APA Li, Yu-Feng.,Dong, Zeqin.,Chen, Chunying.,Li, Bai.,Gao, Yuxi.,...&Chai, Zhifang.(2012).Organic Selenium Supplementation Increases Mercury Excretion and Decreases Oxidative Damage in Long-Term Mercury-Exposed Residents from Wanshan, China.ENVIRONMENTAL SCIENCE & TECHNOLOGY,46(20),11313-11318.
MLA Li, Yu-Feng,et al."Organic Selenium Supplementation Increases Mercury Excretion and Decreases Oxidative Damage in Long-Term Mercury-Exposed Residents from Wanshan, China".ENVIRONMENTAL SCIENCE & TECHNOLOGY 46.20(2012):11313-11318.
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