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学科主题: 临床医学
题名:
Cancer stem cell marker CD133+ tumour cells and clinical outcome in rectal cancer
作者: Wang, Qi1,2; Chen, Zhi-Guo1,2; Du, Chang-Zheng1,2; Wang, Hong-Wei1,2; Yan, Li3; Gu, Jin1,2
关键词: cancer stem cells ; prognosis ; rectal carcinoma
刊名: HISTOPATHOLOGY
发表日期: 2009-09-01
DOI: 10.1111/j.1365-2559.2009.03378.x
卷: 55, 期:3, 页:284-293
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Pathology
研究领域[WOS]: Cell Biology ; Pathology
关键词[WOS]: COLORECTAL-CANCER ; PREOPERATIVE CHEMORADIATION ; TISSUE MICROARRAY ; COLON-CANCER ; EXPRESSION ; SURVIVAL ; IDENTIFICATION ; RADIATION ; DISEASE ; CATENIN
英文摘要:

Aims:

The CD133 antigen has been identified as a putative stem cell marker in colorectal cancer tissues. According to the cancer stem cell hypothesis, CD133+ cells determine long-term tumour growth and are therefore suspected of influencing clinical outcome. The aim was to investigate the prognostic value of CD133 expression in rectal cancer patients after preoperative radiation and curative resection.

Methods and results:

The expression of the CD133 stem cell antigen in a series of 73 patients with rectal cancer of various ypTNM stages was analysed by immunohistochemistry on formalin-fixed paraffin-embedded sections. The prognostic value of CD133 expression and other clinicopathological factors was evaluated. On multivariate survival analysis, the proportion of CD133+ cells was a significant (P < 0.05) prognostic factor for adverse disease-free survival and overall survival independent of ypTNM stage, tumour differentiation or lymphovascular invasion.

Conclusions:

CD133 stem cell antigen expression correlates with patient survival in rectal cancer, lending support to the current cancer stem cell hypothesis.

语种: 英语
所属项目编号: 2005-1019
项目资助者: Capital Development of Medical Research Fund Project
WOS记录号: WOS:000269677500006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53044
Appears in Collections:北京大学临床肿瘤学院_胃肠肿瘤中心_期刊论文

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作者单位: 1.Peking Univ, Sch Oncol, Dept Colorectal Surg, Beijing Canc Hosp, Beijing 100871, Peoples R China
2.Peking Univ, Sch Oncol, Beijing Canc Inst, Beijing 100871, Peoples R China
3.Peking Univ, Sch Oncol, Beijing Canc Res Inst, Beijing 100871, Peoples R China

Recommended Citation:
Wang, Qi,Chen, Zhi-Guo,Du, Chang-Zheng,et al. Cancer stem cell marker CD133+ tumour cells and clinical outcome in rectal cancer[J]. HISTOPATHOLOGY,2009,55(3):284-293.
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