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学科主题临床医学
Cancer stem cell marker CD133+ tumour cells and clinical outcome in rectal cancer
Wang, Qi1,2; Chen, Zhi-Guo1,2; Du, Chang-Zheng1,2; Wang, Hong-Wei1,2; Yan, Li3; Gu, Jin1,2
关键词Cancer Stem Cells Prognosis Rectal Carcinoma
刊名HISTOPATHOLOGY
2009-09-01
DOI10.1111/j.1365-2559.2009.03378.x
55期:3页:284-293
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Pathology
研究领域[WOS]Cell Biology ; Pathology
关键词[WOS]COLORECTAL-CANCER ; PREOPERATIVE CHEMORADIATION ; TISSUE MICROARRAY ; COLON-CANCER ; EXPRESSION ; SURVIVAL ; IDENTIFICATION ; RADIATION ; DISEASE ; CATENIN
英文摘要

Aims:

The CD133 antigen has been identified as a putative stem cell marker in colorectal cancer tissues. According to the cancer stem cell hypothesis, CD133+ cells determine long-term tumour growth and are therefore suspected of influencing clinical outcome. The aim was to investigate the prognostic value of CD133 expression in rectal cancer patients after preoperative radiation and curative resection.

Methods and results:

The expression of the CD133 stem cell antigen in a series of 73 patients with rectal cancer of various ypTNM stages was analysed by immunohistochemistry on formalin-fixed paraffin-embedded sections. The prognostic value of CD133 expression and other clinicopathological factors was evaluated. On multivariate survival analysis, the proportion of CD133+ cells was a significant (P < 0.05) prognostic factor for adverse disease-free survival and overall survival independent of ypTNM stage, tumour differentiation or lymphovascular invasion.

Conclusions:

CD133 stem cell antigen expression correlates with patient survival in rectal cancer, lending support to the current cancer stem cell hypothesis.

语种英语
WOS记录号WOS:000269677500006
项目编号2005-1019
资助机构Capital Development of Medical Research Fund Project
引用统计
被引频次:56[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53044
专题北京大学临床肿瘤学院_胃肠肿瘤中心
北京大学临床肿瘤学院_肝胆胰外一科
北京大学临床肿瘤学院_结直肠肿瘤外科
作者单位1.Peking Univ, Sch Oncol, Dept Colorectal Surg, Beijing Canc Hosp, Beijing 100871, Peoples R China
2.Peking Univ, Sch Oncol, Beijing Canc Inst, Beijing 100871, Peoples R China
3.Peking Univ, Sch Oncol, Beijing Canc Res Inst, Beijing 100871, Peoples R China
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Wang, Qi,Chen, Zhi-Guo,Du, Chang-Zheng,et al. Cancer stem cell marker CD133+ tumour cells and clinical outcome in rectal cancer[J]. HISTOPATHOLOGY,2009,55(3):284-293.
APA Wang, Qi,Chen, Zhi-Guo,Du, Chang-Zheng,Wang, Hong-Wei,Yan, Li,&Gu, Jin.(2009).Cancer stem cell marker CD133+ tumour cells and clinical outcome in rectal cancer.HISTOPATHOLOGY,55(3),284-293.
MLA Wang, Qi,et al."Cancer stem cell marker CD133+ tumour cells and clinical outcome in rectal cancer".HISTOPATHOLOGY 55.3(2009):284-293.
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