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学科主题临床医学
Increased phosphorylation of p70 S6 kinase is associated with HPV16 infection in cervical cancer and esophageal cancer
Zhou, Y.1; Pan, Y.1; Zhang, S.1; Shi, X.1; Ning, T.1; Ke, Y.1
关键词S6 Kinase Hpv Akt Cervical Cancer Esophageal Cancer
刊名BRITISH JOURNAL OF CANCER
2007-07-10
DOI10.1038/sj.bjc.6603838
97期:2页:218-222
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]HUMAN-PAPILLOMAVIRUS TYPE-16 ; TUMOR-SUPPRESSOR ; RETINOBLASTOMA PROTEIN ; SIGNALING PATHWAY ; GENE-PRODUCT ; CELL-GROWTH ; E6 PROTEINS ; AKT ; BINDING ; RHEB
英文摘要

HPV16 E6 interacts with and degrades tumour suppressor protein TSC2 leading to the phosphorylation of p70 S6 kinase. We studied the association of S6 kinase phosphorylation and HPV16 infection in cervical cancer and esophageal cancer. Immunohistochemistry was used to assess phosphorylated S6 kinase (Thr 389) and phosphorylated S6 (Ser235/ 236) in 140 cervical cancer and 161 esophageal cancer specimens. Immunohistochemical staining for pS6 kinase and pS6 was significantly more frequent in the HPV16- infected cervical cancer specimens than the HPV16-negative specimens. In contrast, the expression of S6 kinase was similar in both HPV16-positive and -negative samples. The phosphorylation of Akt, the key regulator of S6 kinase, was also detected. Our analysis showed that Akt phosphorylation was unaffected by HPV16 infection. These results together with our previous study suggest that HPV16 modifies S6 kinase activation via mechanism, which activates S6 kinase downstream of Akt function.

语种英语
WOS记录号WOS:000248039400010
引用统计
被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53047
专题北京大学临床肿瘤学院
作者单位1.Anyang Canc Hosp, Dept Surg, Anyang 455000, Peoples R China
2.Peking Univ, Sch Oncol, Beijing Inst Canc Res, Beijing 100036, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Cell Biol, Beijing 100083, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Canc Res Ctr, Beijing 100083, Peoples R China
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GB/T 7714
Zhou, Y.,Pan, Y.,Zhang, S.,et al. Increased phosphorylation of p70 S6 kinase is associated with HPV16 infection in cervical cancer and esophageal cancer[J]. BRITISH JOURNAL OF CANCER,2007,97(2):218-222.
APA Zhou, Y.,Pan, Y.,Zhang, S.,Shi, X.,Ning, T.,&Ke, Y..(2007).Increased phosphorylation of p70 S6 kinase is associated with HPV16 infection in cervical cancer and esophageal cancer.BRITISH JOURNAL OF CANCER,97(2),218-222.
MLA Zhou, Y.,et al."Increased phosphorylation of p70 S6 kinase is associated with HPV16 infection in cervical cancer and esophageal cancer".BRITISH JOURNAL OF CANCER 97.2(2007):218-222.
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