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学科主题: 临床医学
题名:
Increased phosphorylation of p70 S6 kinase is associated with HPV16 infection in cervical cancer and esophageal cancer
作者: Zhou, Y.1; Pan, Y.1; Zhang, S.1; Shi, X.1; Ning, T.1; Ke, Y.1
关键词: S6 kinase ; HPV ; Akt ; cervical cancer ; esophageal cancer
刊名: BRITISH JOURNAL OF CANCER
发表日期: 2007-07-10
DOI: 10.1038/sj.bjc.6603838
卷: 97, 期:2, 页:218-222
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: HUMAN-PAPILLOMAVIRUS TYPE-16 ; TUMOR-SUPPRESSOR ; RETINOBLASTOMA PROTEIN ; SIGNALING PATHWAY ; GENE-PRODUCT ; CELL-GROWTH ; E6 PROTEINS ; AKT ; BINDING ; RHEB
英文摘要:

HPV16 E6 interacts with and degrades tumour suppressor protein TSC2 leading to the phosphorylation of p70 S6 kinase. We studied the association of S6 kinase phosphorylation and HPV16 infection in cervical cancer and esophageal cancer. Immunohistochemistry was used to assess phosphorylated S6 kinase (Thr 389) and phosphorylated S6 (Ser235/ 236) in 140 cervical cancer and 161 esophageal cancer specimens. Immunohistochemical staining for pS6 kinase and pS6 was significantly more frequent in the HPV16- infected cervical cancer specimens than the HPV16-negative specimens. In contrast, the expression of S6 kinase was similar in both HPV16-positive and -negative samples. The phosphorylation of Akt, the key regulator of S6 kinase, was also detected. Our analysis showed that Akt phosphorylation was unaffected by HPV16 infection. These results together with our previous study suggest that HPV16 modifies S6 kinase activation via mechanism, which activates S6 kinase downstream of Akt function.

语种: 英语
WOS记录号: WOS:000248039400010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53047
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Anyang Canc Hosp, Dept Surg, Anyang 455000, Peoples R China
2.Peking Univ, Sch Oncol, Beijing Inst Canc Res, Beijing 100036, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Cell Biol, Beijing 100083, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Canc Res Ctr, Beijing 100083, Peoples R China

Recommended Citation:
Zhou, Y.,Pan, Y.,Zhang, S.,et al. Increased phosphorylation of p70 S6 kinase is associated with HPV16 infection in cervical cancer and esophageal cancer[J]. BRITISH JOURNAL OF CANCER,2007,97(2):218-222.
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