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Serum BAFF and APRIL might be associated with disease activity and kidney damage in patients with anti-glomerular basement membrane disease
Xin, Gang1; Cui, Zhao2; Su, Yun1; Xu, Li-Xia3; Zhao, Ming-Hui2; Li, Kang-Sheng1
关键词Anti-glomerular Basement Membrane Disease a Proliferation Inducing Ligand b Cell Activating FacTor Belonging To The Tumour Necrosis FacTor Family
刊名NEPHROLOGY
2013-03-01
DOI10.1111/nep.12032
18期:3页:209-214
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
资助者National Natural Science Foundation of China ; Guangdong Natural Science Foundation ; National Natural Science Foundation of China ; Guangdong Natural Science Foundation
研究领域[WOS]Urology & Nephrology
关键词[WOS]CRESCENTIC GLOMERULONEPHRITIS ; AUTOIMMUNE-DISEASES ; SJOGRENS-SYNDROME ; OVEREXPRESSION ; AUTOANTIBODIES ; VASCULITIS ; BCMA
英文摘要

Aim B cell activating factor belonging to the tumour necrosis factor family (BAFF) and a proliferation inducing ligand (APRIL) are two tumour necrosis factor (TNF)-like cytokines that were found to be elevated in many autoimmune diseases. Anti-glomerular basement membrane (GBM) disease is a typical severe autoimmune disease characterized by raised serum anti-GBM antibodies. In this study we aimed to detect the serum levels of BAFF and APRIL in patients with anti-GBM disease, and their clinical significance was further analyzed. Methods Forty-seven patients with anti-GBM disease were enrolled in this study. Forty-eight healthy individuals were used as normal controls. The levels of serum BAFF and APRIL were assessed using commercially available enzyme linked immunosorbent assay kits. The association between the levels of serum BAFF and APRIL, and the clinical and pathological parameters were further evaluated. Results The serum levels of BAFF and APRIL in patients with anti-GBM disease were significantly higher than that in normal controls (12.3 +/- 14.1ng/mL vs. 0.9 +/- 0.3ng/mL, P<0.001; 19.1 +/- 22.9ng/mL vs. 1.6 +/- 4.6ng/mL, P<0.001), respectively. The levels of serum APRIL were correlated with the titres of anti-GBM antibodies (r=0.347, P=0.041), and the levels of serum BAFF were associated with the percentage of glomeruli with crescents (r=0.482, P=0.015) in patients with anti-GBM disease. Conclusion The levels of serum BAFF and APRIL were raised in patients with anti-GBM disease and might be associated with disease activity and kidney damage.

语种英语
所属项目编号81200509 ; 81100511 ; 81172795 ; S2012040007470
资助者National Natural Science Foundation of China ; Guangdong Natural Science Foundation ; National Natural Science Foundation of China ; Guangdong Natural Science Foundation
WOS记录号WOS:000315405600010
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53054
专题北京大学第一临床医学院_肾脏内科
作者单位1.Shantou Univ, Dept Microbiol & Immunol, Coll Med, Shantou, Peoples R China
2.Peking Univ, Hosp 1, Div Renal, Beijing 100000, Peoples R China
3.Guangdong Gen Hosp, Dept Nephrol, Guangzhou, Guangdong, Peoples R China
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GB/T 7714
Xin, Gang,Cui, Zhao,Su, Yun,et al. Serum BAFF and APRIL might be associated with disease activity and kidney damage in patients with anti-glomerular basement membrane disease[J]. NEPHROLOGY,2013,18(3):209-214.
APA Xin, Gang,Cui, Zhao,Su, Yun,Xu, Li-Xia,Zhao, Ming-Hui,&Li, Kang-Sheng.(2013).Serum BAFF and APRIL might be associated with disease activity and kidney damage in patients with anti-glomerular basement membrane disease.NEPHROLOGY,18(3),209-214.
MLA Xin, Gang,et al."Serum BAFF and APRIL might be associated with disease activity and kidney damage in patients with anti-glomerular basement membrane disease".NEPHROLOGY 18.3(2013):209-214.
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