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学科主题基础医学
AIB1 as an Independent Prognostic Marker in Hepatocellular Carcinoma After Hepatic Resection
Song, Jun-Min1; Lu, Min2; Liu, Fang-Fang3; Du, Xiao-Juan4,5; Xing, Bao-Cai1
关键词Hepatocellular carcinoma Amplified in breast cancer 1 Prognosis
刊名JOURNAL OF GASTROINTESTINAL SURGERY
2012-02-01
DOI10.1007/s11605-011-1762-9
16期:2页:356-360
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology ; Surgery
研究领域[WOS]Gastroenterology & Hepatology ; Surgery
关键词[WOS]RECEPTOR COACTIVATOR AIB1 ; PROTEIN EXPRESSION ; TISSUE MICROARRAY ; CANCER STATISTICS ; OVARIAN-CANCER ; OVEREXPRESSION ; AMPLIFICATION ; RECURRENCE ; METASTASIS ; MANAGEMENT
英文摘要

Background Amplified in breast cancer 1 (AIB1) has been shown to promote growth and invasion in several types of human cancers and to have a prognostic role in some of cancers. However, its prognostic significance in hepatocellular carcinoma (HCC) remains unknown. This study aimed to address the issue.

Methods Immunohistochemical staining of AIB1 was performed for HCC and paired paratumorous liver (PTL) tissues from 139 patients. Associations between AIB1 expression with clinicopathological variables and patient survival were evaluated.

Results The expression rate of AIB1 was significantly higher in HCC (71/139, 51.1%) than in PTL tissues (1/139, 0.72%, P<0.001). AIB1 expression in HCC was significantly associated with serum a-fetoprotein levels (P=0.001) and Edmondson-Steiner grade (P=0.038). Higher AIB1 expression in HCC was associated with shorter cumulative overall survival of the patients. Multivariate Cox regression analysis revealed that AIB1 was of independent prognostic significance for HCC.

Conclusions AIB1 is independently associated with poor prognosis of HCC.

语种英语
WOS记录号WOS:000300293400022
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53057
专题北京大学基础医学院_病理学系
北京大学基础医学院
北京大学第二临床医学院_病理科
北京大学临床肿瘤学院_肝胆胰外一科
作者单位1.Peking Univ, Key Lab Carcinogenesis & Translat Res, Minist Educ,Beijing Canc Hosp & Inst, Dept Hepat Biliary & Pancreat Surg,Unit 1,Sch Onc, Beijing 100142, Peoples R China
2.Peking Univ, Dept Pathol, Hlth Sci Ctr, Beijing 100142, Peoples R China
3.Peking Univ, Dept Genet, Sch Oncol, Beijing Canc Hosp & Inst, Beijing 100142, Peoples R China
4.Peking Univ, Dept Cell Biol, Hlth Sci Ctr, Beijing 100142, Peoples R China
5.Peking Univ, Canc Res Ctr, Hlth Sci Ctr, Beijing 100142, Peoples R China
推荐引用方式
GB/T 7714
Song, Jun-Min,Lu, Min,Liu, Fang-Fang,et al. AIB1 as an Independent Prognostic Marker in Hepatocellular Carcinoma After Hepatic Resection[J]. JOURNAL OF GASTROINTESTINAL SURGERY,2012,16(2):356-360.
APA Song, Jun-Min,Lu, Min,Liu, Fang-Fang,Du, Xiao-Juan,&Xing, Bao-Cai.(2012).AIB1 as an Independent Prognostic Marker in Hepatocellular Carcinoma After Hepatic Resection.JOURNAL OF GASTROINTESTINAL SURGERY,16(2),356-360.
MLA Song, Jun-Min,et al."AIB1 as an Independent Prognostic Marker in Hepatocellular Carcinoma After Hepatic Resection".JOURNAL OF GASTROINTESTINAL SURGERY 16.2(2012):356-360.
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